SARS-CoV-2 altering angiogenesis via NRP1 (Homo sapiens)

Revision as of 16:01, 18 March 2021 by Fehrhart (Talk | contribs)

Description

Mechanism of how the SARS-cov-2 virus is involved in altering angiogenesis.

View approved pathways at the new wikipathways.org.

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Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, AntÃ³n-PlÃ¡garo C, Shoemark DK, SimÃ³n-Gracia L, Bauer M, Hollandi R, Greber UF, Horvath P, Sessions RB, Helenius A, Hiscox JA, Teesalu T, Matthews DA, Davidson AD, Collins BM, Cullen PJ, Yamauchi Y; ''Neuropilin-1 is a host factor for SARS-CoV-2 infection.''; Science, 2020 PubMed Europe PMC Scholia
Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M; ''Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.''; Cell, 1998 PubMed Europe PMC Scholia
Mayi BS, Leibowitz JA, Woods AT, Ammon KA, Liu AE, Raja A; ''The role of Neuropilin-1 in COVID-19.''; PLoS Pathog, 2021 PubMed Europe PMC Scholia
McFarland AJ, Yousuf MS, Shiers S, Price TJ; ''Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain.''; Pain Rep, 2021 PubMed Europe PMC Scholia
Li ZL, Buck M; ''Neuropilin-1 Assists SARS-CoV-2 Infection by Stimulating the Separation of Spike Protein Domains S1 and S2.''; bioRxiv, 2021 PubMed Europe PMC Scholia
Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, Stratton HJ, Cai S, Luo S, Gonzalez KB, Perez-Miller S, Patwardhan A, Ibrahim MM, Khanna R; ''SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia.''; bioRxiv, 2020 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
124651	view	13:14, 18 November 2022	NhungP	update viral proteins colors and shapes
118890	view	12:13, 3 June 2021	Eweitz	Ontology Term : 'COVID-19' added !
116010	view	07:21, 29 March 2021	Lenaszabo	Modified description
115862	view	16:02, 18 March 2021	Fehrhart	Modified title
115861	view	16:01, 18 March 2021	Fehrhart	Ontology Term : 'severe acute respiratory syndrome' added !
115860	view	16:01, 18 March 2021	Fehrhart	Ontology Term : 'disease pathway' added !
115859	view	16:00, 18 March 2021	Fehrhart	small graphical adaptions
115835	view	14:32, 18 March 2021	Fehrhart	added IDs for S1 and S2
115598	view	12:07, 1 March 2021	SVossen	Modified title
115597	view	12:05, 1 March 2021	SVossen	New pathway

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Name	Type	Database reference
ACE2	GeneProduct	ENSG00000130234 (Ensembl)
Angiogenesis	Pathway	WP1993 (WikiPathways)
FURIN	GeneProduct	ENSG00000140564 (Ensembl)
KDR	GeneProduct	ENSG00000128052 (Ensembl)
Membrane fusion	Pathway	Q6556360 (Wikidata)
NRP1	GeneProduct	ENSG00000099250 (Ensembl)
S1	Protein	Q106020256 (Wikidata)
S2	Protein	Q106020384 (Wikidata)
Surface glycoprotein S	Protein	P0DTC2 (Uniprot-TrEMBL)
VEGFA	GeneProduct	ENSG00000112715 (Ensembl)

No annotated interactions