Selenium micronutrient network (Rattus norvegicus)

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BindingGENERIC ENZYMEPositive effect Transformation PLASMAUnspecified interactions INORGANIC IONGENERIC BINDING PROTEINNegative effect REACTIONINTRACELULARTransportMETABOLITEInfluence on expression BBLeukotriene B4RNSTGlutathioneTNd4 desaturaseCOX1ZincNiacinBGpx1Fads2PGE3IronLA (n-6)Leukotriene D4Vitamin B12Ascorbic acidCatTPGG215-HETEROSAscorbic acidMethionine sulfoxideLA (n-6)TBBTCOX2TRXR 1TryptophanIEAA (n-6)Leukotriene C4AA (n-6)ManganeseCopperBHomocysteineCysteineTRXR 3BRiboflavinBLeukotrieneE4PtgdsIEBSelkEPA (n-3)Hypoxanthine ThioredoxinSod1FMNTLipoxin A4Lipoxin B4SeleniumTALA (n-3)PGE2Fads1Gpx2PGD2BPyridoxal 5'-phosphatePyridoxal 5'-phosphateCopperLeukotriene B4TCysteineBSelRHomocysteinePGFSMethionineZincVitamin B12F2-IsoprostaneC22:5 (n-6)Thromboxane B2BGpx3iPF2-alphaEndoperoxidasePGF2aH2OBBAlox5DHA (n-3)GsrIronT15-HETEglutathione disulfideBBThromboxane A2BFADLeukotriene F4TNFolic acidTRXR 2PGE2Leukotriene D4Methionine XanthineKmoHypoxanthineLipoxin A4Lipoic acidC22:5 (n-6)5-HPETEPGH2NADPa-tocopherolBLeukotriene C4Uric AcidPtgesO2BSepp1Leukotriene A4Leukotriene E4NADPHXdhBBHemeTbxas1SeleniumMthfrH2O2Folic acidUric acidPGI2Gpx4a-TocopherolBBBEPA (n-3)SelWTromboxane A2TMtrPNPOPtgisPGG3GlutathionePGD2NADPPGH3BPGF2aBPGI2DHA (n-3)ALA (n-3)NADPHGpx612


Description

The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at: http://www.selenodb.org.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP15(r29615) with a 55% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC Scholia
  2. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone.''; Prostaglandins., 1982 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120918view06:30, 31 January 2022EgonwReplaced an old HMDB identifier with the current one
117013view11:23, 16 May 2021EweitzModified title
106962view13:42, 17 September 2019MaintBotHMDB identifier normalization
91818view06:29, 31 March 2017EgonwROS is a metabolite, and better annotated with the matching Wikidata ID.
87652view08:54, 25 July 2016LindarieswijkOntology Term : 'selenoamino acid metabolic pathway' added !
82693view18:05, 22 October 2015EgonwFixed a typo.
73553view18:32, 30 January 2014EgonwH2O not H20....
71774view20:30, 17 October 2013MaintBotAutomated update of data sources
69346view18:52, 8 July 2013MaintBotUpdated to 2013 gpml schema
69078view18:09, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
68388view10:11, 4 July 2013EgonwMade the link to Wikipedia machine readable.
68387view10:08, 4 July 2013EgonwFixed a number of DataNode types.
66317view17:34, 17 June 2013MaintBotModified title
58922view05:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58521view20:15, 14 February 2013MaintBotModified title
41659view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
34057view19:04, 9 December 2009MaintBotAutomatic update of empty xrefs
31907view12:48, 14 August 2009MaintBotFixed group labels
31015view01:06, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
15-HETEMetaboliteHMDB0011134 (HMDB)
5-HPETEMetaboliteHMDB0001193 (HMDB)
AA (n-6)MetaboliteHMDB0001043 (HMDB)
ALA (n-3)MetaboliteHMDB0001388 (HMDB)
Alox5Protein25290 (Entrez Gene)
Ascorbic acidMetaboliteHMDB0000044 (HMDB)
BMetabolite
C22:5 (n-6)MetaboliteHMDB0001976 (HMDB)
COX1Protein26195 (Entrez Gene)
COX2Protein26198 (Entrez Gene)
CatProtein24248 (Entrez Gene)
CopperMetaboliteHMDB0000657 (HMDB)
CysteineMetaboliteHMDB0000574 (HMDB)
DHA (n-3)MetaboliteHMDB0002183 (HMDB)
EPA (n-3)MetaboliteHMDB0001999 (HMDB)
EndoperoxidaseProtein
F2-IsoprostaneMetaboliteHMDB0004659 (HMDB)
FADMetaboliteHMDB0001248 (HMDB)
FMNGeneProduct342184 (Entrez Gene)
Fads1Protein84575 (Entrez Gene)
Fads2Protein83512 (Entrez Gene)
Folic acidMetaboliteHMDB0000121 (HMDB)
GlutathioneMetaboliteHMDB0000125 (HMDB)
Gpx1Protein24404 (Entrez Gene)
Gpx2Protein29326 (Entrez Gene)
Gpx3Protein64317 (Entrez Gene)
Gpx4Protein29328 (Entrez Gene)
Gpx6Protein259233 (Entrez Gene)
GsrProteinENSRNOG00000014915 (Ensembl)
H2O2MetaboliteHMDB0003125 (HMDB)
H2OMetaboliteHMDB0002111 (HMDB)
HemeMetaboliteHMDB0003178 (HMDB)
HomocysteineMetaboliteHMDB0000742 (HMDB)
Hypoxanthine MetaboliteHMDB0000157 (HMDB)
HypoxanthineMetaboliteHMDB0000157 (HMDB)
IEMetabolite
IronMetaboliteHMDB0000692 (HMDB)
KmoProtein59113 (Entrez Gene)
LA (n-6)MetaboliteHMDB0000673 (HMDB)
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
Leukotriene F4MetaboliteHMDB0006465 (HMDB)
LeukotrieneE4MetaboliteHMDB0002200 (HMDB)
Lipoic acidMetabolite
Lipoic acidMetaboliteHMDB0001451 (HMDB)
Lipoxin A4MetaboliteHMDB0004385 (HMDB)
Lipoxin B4MetaboliteHMDB0005082 (HMDB)
ManganeseMetaboliteHMDB0001333 (HMDB)
Methionine MetaboliteHMDB0000696 (HMDB)
Methionine sulfoxideMetaboliteHMDB0002005 (HMDB)
MethionineMetaboliteHMDB0000696 (HMDB)
MthfrProtein362657 (Entrez Gene)
MtrProtein81522 (Entrez Gene)
NADPHMetaboliteHMDB0000221 (HMDB)
NADPMetaboliteHMDB0000217 (HMDB)
NiacinMetaboliteHMDB0001406 (HMDB)
O2MetaboliteHMDB0001377 (HMDB)
PGD2MetaboliteHMDB0001403 (HMDB)
PGE2Metabolite
PGE3MetaboliteHMDB0002664 (HMDB)
PGF2aMetaboliteHMDB0001139 (HMDB)
PGFSProtein
PGG2MetaboliteHMDB0003235 (HMDB)
PGG3Metabolite
PGH2MetaboliteHMDB0001381 (HMDB)
PGH3Metabolite
PGI2MetaboliteHMDB0001335 (HMDB)
PNPOProtein64533 (Entrez Gene)
PtgdsProtein25526 (Entrez Gene)
PtgesProtein59103 (Entrez Gene)
PtgisProtein25527 (Entrez Gene)
Pyridoxal 5'-phosphateMetaboliteHMDB0001491 (HMDB)
RNSMetabolite
ROSMetaboliteQ424361 (Wikidata) http://en.wikipedia.org/wiki/Reactive_Oxygen_Species
RiboflavinMetaboliteHMDB0000244 (HMDB)
SelRGeneProduct51734 (Entrez Gene)
SelWGeneProduct6415 (Entrez Gene)
SeleniumMetaboliteHMDB0001349 (HMDB)
SelkProtein290549 (Entrez Gene)
Sepp1Protein29360 (Entrez Gene)
Sod1Protein24786 (Entrez Gene)
TMetabolite
TGeneProduct292301 (Entrez Gene)
TNMetabolite
TRXR 1GeneProduct7296 (Entrez Gene)
TRXR 2GeneProduct10587 (Entrez Gene)
TRXR 3GeneProduct114112 (Entrez Gene)
Tbxas1Protein24886 (Entrez Gene)
ThioredoxinProtein7295 (Entrez Gene)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)
Tromboxane A2MetaboliteHMDB0001452 (HMDB)
TryptophanMetaboliteHMDB0000929 (HMDB)
Uric AcidMetaboliteHMDB0000289 (HMDB)
Uric acidMetabolite
Vitamin B12MetaboliteHMDB0002174 (HMDB)
XanthineMetaboliteHMDB0000292 (HMDB)
XdhProtein497811 (Entrez Gene)
ZincMetaboliteHMDB0001303 (HMDB)
a-TocopherolMetaboliteHMDB0001893 (HMDB)
a-tocopherolMetaboliteHMDB0001893 (HMDB)
d4 desaturaseProtein
glutathione disulfideMetaboliteHMDB0000656 (HMDB)
iPF2-alphaMetaboliteHMDB0004659 (HMDB)

Annotated Interactions

No annotated interactions
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