Oxidative damage response (Mus musculus)

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C4aStress(classical pathway)Inhibitor of Cell DeathInduction of antioxidant genesC3bC5aFormation of apoptotic bodiesProteasomeMitochondrial pathwayComplement activationMembrane lysis complexC4b/2aROSC3aNf-kB pathwayC3-convertaseC3b/4b, C3b, C3dActivator of Cell DeathMuscle contraction,Chemotaxis,Phagocyte recruitment,Inflammation etcROSLiver regenerationCell lysis and clearanceGSHAdaptive response in liverCell survivalBag4Casp9Traf2Map2k6Tnk2CycsApoptosisMapk13Nfkb1Cdc42Traf1Bcl2C1rGadd45aC3ar1Traf3Mapk12DNA ReplicationTnfMap3k9CyctCdkn1bOxidative stressCasp3Traf6C1qaTnfrsf1bC4C1qbC1sApaf1Mapk14BadMap3k1Bak1Cdkn1aPcnaCr2Cdkn1cHcC5r1TtrapC2C1qg


Description

This pathway shows how tissue is damaged when oxygen levels are not balanced and become too high.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
126385view10:08, 26 April 2023EgonwLicense is CCZero
120957view10:40, 3 February 2022EgonwMade three pathways clickable
117039view14:12, 16 May 2021EweitzModified title
90720view20:45, 13 December 2016KhanspersModified description
90169view14:17, 20 October 2016Mkutmonfix unconnected lines
79337view12:13, 21 March 2015EgonwReplaced a batch of gene names with their Entrez gene IDs.
78428view10:26, 7 January 2015MaintBotadded missing graphIds
75225view18:12, 12 May 2014Khanspersadded pathway nodes
75223view17:54, 12 May 2014Khanspersfixed label and most xrefs
69181view18:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67560view11:26, 26 June 2013DdiglesOntology Term : 'oxidative stress response pathways' added !
43789view21:45, 27 July 2011Samuel SklarModified description
43788view21:41, 27 July 2011Samuel SklarSpecify description
41370view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
36318view17:55, 19 March 2010MaintBotModified categories
36313view22:19, 18 March 2010MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Apaf1GeneProduct11783 (Entrez Gene)
ApoptosisPathwayWP1254 (WikiPathways)
BadGeneProduct12015 (Entrez Gene)
Bag4GeneProduct67384 (Entrez Gene)
Bak1GeneProduct12018 (Entrez Gene)
Bcl2GeneProduct12043 (Entrez Gene)
C1qaGeneProduct12259 (Entrez Gene)
C1qbGeneProduct12260 (Entrez Gene)
C1qgGeneProduct12262 (Entrez Gene)
C1rGeneProduct50909 (Entrez Gene)
C1sGeneProduct50908 (Entrez Gene)
C2GeneProduct12263 (Entrez Gene)
C3ar1GeneProduct12267 (Entrez Gene)
C4GeneProduct12268 (Entrez Gene)
C5r1GeneProduct12273 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Casp9GeneProduct12371 (Entrez Gene)
Cdc42GeneProduct12540 (Entrez Gene)
Cdkn1aGeneProduct12575 (Entrez Gene)
Cdkn1bGeneProduct12576 (Entrez Gene)
Cdkn1cGeneProduct12577 (Entrez Gene)
Cr2GeneProduct12902 (Entrez Gene)
CycsGeneProduct13063 (Entrez Gene) Rel,Nup93,Nrf1,Them2,Syap1,Zfp259,2700059L22Rik,,Cotl1
CyctGeneProduct13067 (Entrez Gene)
DNA ReplicationPathwayWP150 (WikiPathways)
Gadd45aGeneProduct13197 (Entrez Gene)
HcGeneProduct15139 (Entrez Gene)
Map2k6GeneProduct26398 (Entrez Gene) Xbp1,Mapk10,Klhl8,Mapk10
Map3k1GeneProduct26401 (Entrez Gene)
Map3k9GeneProduct338372 (Entrez Gene)
Mapk12GeneProduct18037 (Entrez Gene)
Mapk13GeneProduct26415 (Entrez Gene)
Mapk14GeneProduct26414 (Entrez Gene) Map2k4,Nlk,Fos,Fzd7,Jund1,ORF19,Map2k4,Dhodh,Map3k7,Dvl3,Eda,Rac1,Jup,Mllt4,Mink1,Myef2,Dusp10,Rala,Etv6,Frk,Wee1,Rexo1
Nfkb1GeneProduct18033 (Entrez Gene)
Oxidative stressPathwayWP412 (WikiPathways)
PcnaGeneProduct18538 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)
Tnfrsf1bGeneProduct21938 (Entrez Gene)
Tnk2GeneProduct51789 (Entrez Gene)
Traf1GeneProduct22029 (Entrez Gene)
Traf2GeneProduct22030 (Entrez Gene)
Traf3GeneProduct22031 (Entrez Gene)
Traf6GeneProduct22034 (Entrez Gene)
TtrapGeneProduct56196 (Entrez Gene)

Annotated Interactions

No annotated interactions

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