Genes controlling nephrogenesis (Homo sapiens)

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2regulationGLI3LHX1HNF1BSHHILKETV4CTNNB11Ureteric bud inductionPretubular aggregationMature glomerulusCapillaryloopS-shapeNephrogenesisComma-shapeEYA13ITGB1ITGA3LMX1BGDNFCXCR4SIX1FOXD1PDGFBHOXA11CXCL12VEGFAKIRREL1LAMB2KDRWT1LHX1FOXC2NCK1ITGA8NPHS2NPHS1FGF8RETCD2APWNT4ROBO2NCK2ITGB1FOXC1NOTCH2TCF21PDGFRBPAX2CD36SLIT2EMX2FGFR2HOXD11HNF1B1HNF1B1


Description

Kidneys develop from intermediate mesoderm under the timed or sequential control of a growing number of genes. These genes have been identified at various stages of glomerulotubular development in the mammalian kidney. The genes listed have been tested in various genetically modified mice, and their location corresponds to the classical stages of kidney development postulated by Saxen in 1987.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Heidet L, Decramer S, Pawtowski A, Morinière V, Bandin F, Knebelmann B, Lebre AS, Faguer S, Guigonis V, Antignac C, Salomon R; ''Spectrum of HNF1B mutations in a large cohort of patients who harbor renal diseases.''; Clin J Am Soc Nephrol, 2010 PubMed Europe PMC Scholia
  2. Jameson J, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J; ''Cellular and Molecular Biology of the Kidney. In: Jameson J, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. eds. Harrison's Principles of Internal Medicine, 20e. McGraw-Hill''; https://accessmedicine.mhmedical.com/content.aspx?bookid=2129&sectionid=181950772, 2018
  3. Abdelhak S, Kalatzis V, Heilig R, Compain S, Samson D, Vincent C, Levi-Acobas F, Cruaud C, Le Merrer M, Mathieu M, König R, Vigneron J, Weissenbach J, Petit C, Weil D; ''Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1.''; Hum Mol Genet, 1997 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
119116view16:25, 17 June 2021Finterlyadded ISBN information
118776view15:58, 1 June 2021FehrhartOntology Term : 'CAKUT' added !
118772view15:45, 1 June 2021Fehrhartadded reference for EYA1
118764view15:23, 1 June 2021Fehrhartadded information and literature for HNF1B and LHX1
115204view15:42, 4 February 2021FehrhartCAKUT expert curation round 1
115201view10:54, 4 February 2021FehrhartModified title
109268view09:10, 3 March 2020Fehrhartupdate
109163view13:53, 21 February 2020Iulia.ioncuOntology Term : 'signaling pathway' added !
109153view17:58, 18 February 2020Iulia.ioncuModified description
109152view16:39, 18 February 2020Iulia.ioncuNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CD2APGeneProductENSG00000198087 (Ensembl)
CD36GeneProductENSG00000135218 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
EMX2GeneProductENSG00000170370 (Ensembl)
ETV4GeneProductENSG00000175832 (Ensembl)
EYA1GeneProductENSG00000104313 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FOXC1GeneProductENSG00000054598 (Ensembl)
FOXC2GeneProductENSG00000176692 (Ensembl)
FOXD1GeneProductENSG00000251493 (Ensembl)
GDNFGeneProductENSG00000168621 (Ensembl)
GLI3GeneProductENSG00000106571 (Ensembl)
HNF1BGeneProductENSG00000275410 (Ensembl)
HOXA11GeneProductENSG00000005073 (Ensembl)
HOXD11GeneProductENSG00000128713 (Ensembl)
ILKGeneProductENSG00000166333 (Ensembl)
ITGA3GeneProductENSG00000005884 (Ensembl)
ITGA8GeneProductENSG00000077943 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
KDRGeneProductENSG00000128052 (Ensembl)
KIRREL1GeneProductENSG00000183853 (Ensembl)
LAMB2GeneProductENSG00000172037 (Ensembl)
LHX1GeneProductENSG00000273706 (Ensembl)
LMX1BGeneProductENSG00000136944 (Ensembl)
NCK1GeneProductENSG00000158092 (Ensembl)
NCK2GeneProductENSG00000071051 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
NPHS1GeneProductENSG00000161270 (Ensembl)
NPHS2GeneProductENSG00000116218 (Ensembl)
PAX2GeneProductENSG00000075891 (Ensembl)
PDGFBGeneProductENSG00000100311 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
RETGeneProductENSG00000165731 (Ensembl)
ROBO2GeneProductENSG00000185008 (Ensembl)
SHHGeneProductENSG00000164690 (Ensembl)
SIX1GeneProductENSG00000126778 (Ensembl)
SLIT2GeneProductENSG00000145147 (Ensembl)
TCF21GeneProductENSG00000118526 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
WT1GeneProductENSG00000184937 (Ensembl)

Annotated Interactions

No annotated interactions

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