Hypoxia-dependent self-renewal of myoblasts (Mus musculus)
From WikiPathways
Description
Molecular mechanisms involved in self-renewal of satellite cells in hypoxia. Black arrows: activation of the signaling pathway / protein / molecule. Blunt red arrow: inhibition of the signaling pathway / protein / molecule. Round blue arrow: interaction between two pathways.
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Ontology Terms
Saving...Bibliography
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- Liu W, Wen Y, Bi P, Lai X, Liu XS, Liu X, Kuang S; ''Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation.''; Development, 2012 PubMed Europe PMC Scholia
- Li X, Zhu L, Chen X, Fan M; ''Effects of hypoxia on proliferation and differentiation of myoblasts.''; Med Hypotheses, 2007 PubMed Europe PMC Scholia
- Majmundar AJ, Skuli N, Mesquita RC, Kim MN, Yodh AG, Nguyen-McCarty M, Simon MC; ''O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling.''; Mol Cell Biol, 2012 PubMed Europe PMC Scholia
- Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D; ''A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.''; J Clin Invest, 2007 PubMed Europe PMC Scholia
- Ren H, Accili D, Duan C; ''Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
- Horak M, Novak J, Bienertova-Vasku J; ''Muscle-specific microRNAs in skeletal muscle development.''; Dev Biol, 2016 PubMed Europe PMC Scholia
- Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, Wang DZ; ''microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7.''; J Cell Biol, 2010 PubMed Europe PMC Scholia
- Di Carlo A, De Mori R, Martelli F, Pompilio G, Capogrossi MC, Germani A; ''Hypoxia inhibits myogenic differentiation through accelerated MyoD degradation.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
- Sinha KM, Tseng C, Guo P, Lu A, Pan H, Gao X, Andrews R, Eltzschig H, Huard J; ''Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice.''; FASEB J, 2019 PubMed Europe PMC Scholia
- Dey BK, Gagan J, Dutta A; ''miR-206 and -486 induce myoblast differentiation by downregulating Pax7.''; Mol Cell Biol, 2011 PubMed Europe PMC Scholia
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| CDKN1A | GeneProduct | 12575 (Entrez Gene)  | |
| FoxO1 | GeneProduct | 56458 (Entrez Gene) | |
| HIF1a | GeneProduct | 15251 (Entrez Gene) | |
| HSP90 | GeneProduct | ENSMUSG00000020048 (Ensembl) | |
| Hes1 | GeneProduct | 15205 (Entrez Gene) | |
| Hey1 | GeneProduct | 15213 (Entrez Gene) | |
| Hey2 | GeneProduct | 15214 (Entrez Gene) | |
| Hypoxia | |||
| MAPK14 | GeneProduct | MAPK14 (HGNC) | |
| MYF5 | GeneProduct | 17877 (Entrez Gene) | |
| MYH | GeneProduct | 17879 (Entrez Gene) | |
| MYOD1 | GeneProduct | 17927 (Entrez Gene) | |
| MYOG | GeneProduct | 17928 (Entrez Gene) | |
| Myotube formation | |||
| Notch-pathway | Pathway | 18128 (Entrez Gene) | |
| PAX7 | GeneProduct | 18509 (Entrez Gene) | |
| RB | GeneProduct | ||
| Self renewal | |||
| WNT non canonical | Pathway | ||
| miR1 | Rna | ||
| miR206 | Rna |
Annotated Interactions
No annotated interactions
