ALA oxylipin metabolism (Homo sapiens)

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29,10-DiHODEALOX5sEH15,16-DiHODEALOX15alpha-Linolenic acid13-HOTrEALA9-HOTrEcytochrome P4509-OxoOTrE13-OxoOTrE12,13-DiHODE9(S)-HpOTrE13(S)-HpOTrE9(10)-EpODE15(16)-EpODE112(13)-EpODEDGLA8-HETrE15S-HETrEPGE15-HETrETXB1AA8(9)-EpETrE8,9-DiHETrE14(15)-EpETrE14,15-DiHETrEPGH2?PGE2TXB2PGF2a11,12-DiHETrE13-HODE12-HETE15-HETE5-HETE8-HETE12-KETE11-HETE5,6-DiHETrE15-KETE12S-HHTrE5-KETE5-IPF2a-VI19-HETEDHAEPADGLAAALAEDA


Description

alpha-Linolenic acid (ALA) oxylipin metabolism

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Quality Tags

Ontology Terms

 

Bibliography

  1. Galliard T, Phillips DR; ''Lipoxygenase from potato tubers. Partial purification and properties of an enzyme that specifically oxygenates the 9-position of linoleic acid.''; Biochem J, 1971 PubMed Europe PMC Scholia
  2. Gabbs M, Leng S, Devassy JG, Monirujjaman M, Aukema HM; ''Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs.''; Adv Nutr, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134570view22:59, 22 July 2024EweitzModified description
126553view18:01, 31 May 2023LcayerFixed multiple incorrect changes. The root fatty acid was changed. And the 13-hydroxy metabolite metabolites were each inccorectly changed to linoleic acid metabolites
126552view17:42, 31 May 2023LcayerReverted to version '18:55, 14 April 2023' by Lcayer
126551view17:42, 31 May 2023LcayerReverted to version '19:27, 30 April 2023' by Lcayer
126550view17:36, 31 May 2023LcayerGave ALA alpha symbol
126446view19:27, 30 April 2023AlexanderPicoModified description
126445view19:26, 30 April 2023AlexanderPicoModified title
126203view18:55, 14 April 2023Khanspersupdated 13-HpODE arm
125624view20:03, 5 March 2023AlexanderPicoModified description
120082view15:31, 1 November 2021MkutmonOntology Term : 'lipid metabolic pathway' added !
120067view23:28, 25 October 2021LcayerAdded metabolite 9,16-DiHOTrE
120062view19:51, 25 October 2021Lcayerextraneous information removed
120061view19:33, 25 October 2021LcayerNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11,12-DiHETrEMetabolite5283146 (PubChem-compound)
11-HETEMetabolite14123410 (PubChem-compound)
12(13)-EpODEMetabolite16061061 (PubChem-compound)
12,13-DiHODEMetaboliteHMDB10201 (HMDB)
12-HETEMetabolite13786989 (PubChem-compound)
12-KETEMetabolite5283162 (PubChem-compound)
12S-HHTrEMetabolite5283141 (PubChem-compound)
13(S)-HpOTrEMetaboliteCHEBI:48905 (ChEBI)
13-HODEMetabolite5282947 (PubChem-compound)
13-HOTrEMetabolite16061072 (PubChem-compound)
13-OxoOTrEMetabolite
14(15)-EpETrEMetabolite5283205 (PubChem-compound)
14,15-DiHETrEMetabolite5283147 (PubChem-compound)
15(16)-EpODEMetaboliteHMDB10206 (HMDB)
15,16-DiHODEMetaboliteHMDB10208 (HMDB)
15-HETEMetabolite5312986 (PubChem-compound)
15-KETEMetabolite5280701 (PubChem-compound)
15S-HETrEMetabolite5283145 (PubChem-compound)
19-HETEMetabolite20839325 (PubChem-compound)
5,6-DiHETrEMetabolite5283142 (PubChem-compound)
5-HETEMetabolite9862886 (PubChem-compound)
5-HETrEMetabolite16759351 (PubChem-compound)
5-IPF2a-VIMetabolite77519415 (PubChem-compound)
5-KETEMetabolite5353355 (PubChem-compound)
8(9)-EpETrEMetabolite5353364 (PubChem-compound)
8,9-DiHETrEMetabolite5283144 (PubChem-compound)
8-HETEMetabolite11976122 (PubChem-compound)
8-HETrEMetabolite71306337 (PubChem-compound)
9(10)-EpODEMetaboliteHMDB10220 (HMDB)
9(S)-HpOTrEMetaboliteCHEBI:60961 (ChEBI)
9,10-DiHODEMetaboliteHMDB10221 (HMDB)
9-HOTrEMetabolite10447175 (PubChem-compound)
9-OxoOTrEMetabolite125559-74-2 (CAS)
AA
AAMetabolite444899 (PubChem-compound)
ALAMetabolite5280934 (PubChem-compound)
ALOX15GeneProductENSG00000161905 (Ensembl)
ALOX5GeneProductENSG00000012779 (Ensembl)
DGLA


DGLAMetabolite5280581 (PubChem-compound)
DHAMetabolite445580 (PubChem-compound)
EDAMetabolite6439848 (PubChem-compound)
EPAMetabolite446284 (PubChem-compound)
LAMetabolite5280450 (PubChem-compound)
PGE1Metabolite5280723 (PubChem-compound)
PGE2Metabolite5280360 (PubChem-compound)
PGF2aMetabolite5280363 (PubChem-compound)
PGH2?
TXB1Metabolite71668258 (PubChem-compound)
TXB2Metabolite5283137 (PubChem-compound)
alpha-Linolenic acidMetaboliteCHEBI:27432 (ChEBI)
cytochrome P450MetaboliteCHEBI:38559 (ChEBI)
sEHGeneProductENSG00000120915 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5136"
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