NRP1-triggered signaling in pancreatic cancer (Homo sapiens)
From WikiPathways
Description
NRP1 triggered signaling pathways in pancreatic cancer
Quality Tags
Ontology Terms
Pathway Ontology : methylmalonic aciduria, cobalamin-related pathway mitochondria dynamics pathway cobalamin metabolic pathway
Disease : methylmalonic acidemia methylmalonic aciduria and homocystinuria type cblF methylmalonic aciduria and homocystinuria type cblC vitamin B12 deficiency methylmalonic acidemia cb1A type methylmalonic aciduria and homocystinuria type cblD methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency methylmalonic acidemia cb1B type
Cell Type : metabolising cell eukaryotic cell
Bibliography
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- Prud'homme GJ, Glinka Y; ''Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity.''; Oncotarget, 2012 PubMed Europe PMC Scholia
- Matkar PN, Jong ED, Ariyagunarajah R, Prud'homme GJ, Singh KK, Leong-Poi H; ''Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer.''; Cancer Med, 2018 PubMed Europe PMC Scholia
- Lu D, Shang G, He X, Bai XC, Zhang X; ''Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex.''; Nat Commun, 2021 PubMed Europe PMC Scholia
- Li L, Jiang X, Zhang Q, Dong X, Gao Y, He Y, Qiao H, Xie F, Xie X, Sun X; ''Neuropilin-1 is associated with clinicopathology of gastric cancer and contributes to cell proliferation and migration as multifunctional co-receptors.''; J Exp Clin Cancer Res, 2016 PubMed Europe PMC Scholia
- Matkar PN, Singh KK, Rudenko D, Kim YJ, Kuliszewski MA, Prud'homme GJ, Hedley DW, Leong-Poi H; ''Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma.''; Oncotarget, 2016 PubMed Europe PMC Scholia
- Zachary IC, Frankel P, Evans IM, Pellet-Many C; ''The role of neuropilins in cell signalling.''; Biochem Soc Trans, 2009 PubMed Europe PMC Scholia
- Yoshida A, Shimizu A, Asano H, Kadonosono T, Kondoh SK, Geretti E, Mammoto A, Klagsbrun M, Seo MK; ''VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells.''; Biol Open, 2015 PubMed Europe PMC Scholia
- Donahue T, Hines OJ; ''The ZIP4 pathway in pancreatic cancer.''; Cancer Biol Ther, 2010 PubMed Europe PMC Scholia
- Matsushita A, Götze T, Korc M; ''Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1.''; Cancer Res, 2007 PubMed Europe PMC Scholia
- Müller MW, Giese NA, Swiercz JM, Ceyhan GO, Esposito I, Hinz U, Büchler P, Giese T, Büchler MW, Offermanns S, Friess H; ''Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer.''; Int J Cancer, 2007 PubMed Europe PMC Scholia
- Ma L, Zhai B, Zhu H, Li W, Jiang W, Lei L, Zhang S, Qiao H, Jiang X, Sun X; ''The miR-141/neuropilin-1 axis is associated with the clinicopathology and contributes to the growth and metastasis of pancreatic cancer.''; Cancer Cell Int, 2019 PubMed Europe PMC Scholia
- Zhu H, Jiang X, Zhou X, Dong X, Xie K, Yang C, Jiang H, Sun X, Lu J; ''Neuropilin-1 regulated by miR-320 contributes to the growth and metastasis of cholangiocarcinoma cells.''; Liver Int, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
AKT1 | GeneProduct | P31749 (Uniprot-TrEMBL) ![]() | |
AKT2 | Protein | P31751 (Uniprot-TrEMBL) ![]() | |
AKT3 | Protein | Q9Y243 (Uniprot-TrEMBL) ![]() | |
CD31 | GeneProduct | ENSG00000261371 (Ensembl) ![]() | |
CDH5 | GeneProduct | ENSG00000179776 (Ensembl) ![]() | |
CDK2 | Complex | ENSG00000123374 (Ensembl) ![]() | |
COL1A1 | Protein | ENSG00000108821 (Ensembl) ![]() | |
CRMP1 | GeneProduct | ENSG00000072832 (Ensembl) ![]() | |
CTGF | Protein | ENSG00000118523 (Ensembl) ![]() | |
Cell proliferation | Pathway | ||
E-cadherin 1 | Protein | A0A0U2ZQU7 (Uniprot-TrEMBL) ![]() | |
EGFR | GeneProduct | ENSG00000146648 (Ensembl) ![]() | |
ERK | Metabolite | CHEBI:17300 (ChEBI) ![]() | |
EndMT | Pathway | ||
Epithelial- mesenchymal transition (EMT) | Pathway | ||
FAK | GeneProduct | ENSG00000169398 (Ensembl) ![]() | |
FARP2 | GeneProduct | ENSG00000006607 (Ensembl) ![]() | |
Fibrosis | Pathway | ||
GSK3 | GeneProduct | ENSG00000105723 (Ensembl) ![]() | |
MAPK | Pathway | ||
MAPK11 | GeneProduct | ||
MAPK12 | GeneProduct | ||
MAPK13 | GeneProduct | ||
MAPK14 | GeneProduct | ||
MEK | Metabolite | CHEBI:28398 (ChEBI) ![]() | |
MMP2 | GeneProduct | ENSG00000087245 (Ensembl) ![]() | |
MMP9 | GeneProduct | ENSG00000100985 (Ensembl) ![]() | |
Metastasis | Pathway | ||
MiR-141 | Rna | ENSG00000207708 (Ensembl) ![]() | |
Migration, Invasion | Pathway | ||
N-cadherin | GeneProduct | ||
NRP | GeneProduct | ||
NRP1 | GeneProduct | ENSG00000099250 (Ensembl) ![]() | |
NRP1 | Protein | O14786 (Uniprot-TrEMBL) ![]() | |
PDGFR | Metabolite | CHEBI:133397 (ChEBI) ![]() | |
PI3K | GeneProduct | ||
PLXNA1-A4 | GeneProduct | ||
SHB | GeneProduct | ENSG00000107338 (Ensembl) ![]() | |
SMAD2 | GeneProduct | ENSG00000175387 (Ensembl) ![]() | |
SMAD3 | GeneProduct | ENSG00000166949 (Ensembl) ![]() | |
SMAD4 | GeneProduct | ENSG00000141646 (Ensembl) ![]() | |
SNAI1 | GeneProduct | ENSG00000124216 (Ensembl) ![]() | |
SNAI2 | GeneProduct | ENSG00000019549 (Ensembl) ![]() | |
SRC | GeneProduct | ENSG00000197122 (Ensembl) ![]() | |
TGFBR2 | GeneProduct | ENSG00000163513 (Ensembl) ![]() | |
VEGFR2 | GeneProduct | P17948 (Uniprot-TrEMBL) ![]() | |
ZIP4 | Protein | A6NDY5 (Uniprot-TrEMBL) ![]() | |
c-met | GeneProduct | ENSG00000105976 (Ensembl) ![]() | |
cyclin E | Metabolite | CHEBI:82665 (ChEBI) ![]() | |
p130Cas | Protein | ||
p27 | GeneProduct | ENSG00000111276 (Ensembl) ![]() |
Annotated Interactions
No annotated interactions