NRP1-triggered signaling in pancreatic cancer (Homo sapiens)

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7363533VEGFTGF-betaSEMA3VEGFZINCCD31MetastasisTGFBR2Cell proliferationCRMP1p27SMAD2PLXNA4SMAD3NRP1MAPK11MMP2SMAD2PI3KZIP4SNAI2Epithelial- mesenchymal transition(EMT)SHBMigration, InvasionNRP1MAPK13AKT3AKT1MiR-141GSK3SNAI1VEGFR2COL1A1FibrosisNRP1EndMTCTGFMAPK12PDGFR NRP1FAKSMAD4MMP9SRCcyclin E CDH1CDH5p130CasCDH2MEKMAPKNRP1MAPK14ERKNRP1FARP2c-metAKT2CDK234P447333143, 4273P2, 773P33, 73P364234P2, 772P33, 72, 7P66466P3, 443EGFR2, 7NRP17


Description

NRP1 triggered signaling pathways in pancreatic cancer

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Donahue T, Hines OJ; ''The ZIP4 pathway in pancreatic cancer.''; Cancer Biol Ther, 2010 PubMed Europe PMC Scholia
  2. Zhu H, Jiang X, Zhou X, Dong X, Xie K, Yang C, Jiang H, Sun X, Lu J; ''Neuropilin-1 regulated by miR-320 contributes to the growth and metastasis of cholangiocarcinoma cells.''; Liver Int, 2018 PubMed Europe PMC Scholia
  3. Matkar PN, Singh KK, Rudenko D, Kim YJ, Kuliszewski MA, Prud'homme GJ, Hedley DW, Leong-Poi H; ''Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma.''; Oncotarget, 2016 PubMed Europe PMC Scholia
  4. Li L, Jiang X, Zhang Q, Dong X, Gao Y, He Y, Qiao H, Xie F, Xie X, Sun X; ''Neuropilin-1 is associated with clinicopathology of gastric cancer and contributes to cell proliferation and migration as multifunctional co-receptors.''; J Exp Clin Cancer Res, 2016 PubMed Europe PMC Scholia
  5. Prud'homme GJ, Glinka Y; ''Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity.''; Oncotarget, 2012 PubMed Europe PMC Scholia
  6. Lu D, Shang G, He X, Bai XC, Zhang X; ''Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex.''; Nat Commun, 2021 PubMed Europe PMC Scholia
  7. Ma L, Zhai B, Zhu H, Li W, Jiang W, Lei L, Zhang S, Qiao H, Jiang X, Sun X; ''The miR-141/neuropilin-1 axis is associated with the clinicopathology and contributes to the growth and metastasis of pancreatic cancer.''; Cancer Cell Int, 2019 PubMed Europe PMC Scholia
  8. Yoshida A, Shimizu A, Asano H, Kadonosono T, Kondoh SK, Geretti E, Mammoto A, Klagsbrun M, Seo MK; ''VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells.''; Biol Open, 2015 PubMed Europe PMC Scholia
  9. Müller MW, Giese NA, Swiercz JM, Ceyhan GO, Esposito I, Hinz U, Büchler P, Giese T, Büchler MW, Offermanns S, Friess H; ''Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer.''; Int J Cancer, 2007 PubMed Europe PMC Scholia
  10. Zachary IC, Frankel P, Evans IM, Pellet-Many C; ''The role of neuropilins in cell signalling.''; Biochem Soc Trans, 2009 PubMed Europe PMC Scholia
  11. Matkar PN, Jong ED, Ariyagunarajah R, Prud'homme GJ, Singh KK, Leong-Poi H; ''Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer.''; Cancer Med, 2018 PubMed Europe PMC Scholia
  12. Matsushita A, Götze T, Korc M; ''Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1.''; Cancer Res, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129754view01:59, 22 May 2024EweitzModified title
129321view13:57, 26 March 2024MkutmonOntology Term : 'cancer pathway' added !
129320view13:57, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
120537view18:42, 12 December 2021Nadiapan1
120532view19:20, 11 December 2021Nadiapan1
120529view16:27, 11 December 2021Nadiapan1
120520view15:45, 10 December 2021Mkutmonfix identifier
120519view15:43, 10 December 2021Mkutmonupdate identifiers
120518view15:28, 10 December 2021Mkutmonupdate identifiers
120517view15:23, 10 December 2021Mkutmonupdate identifiers
120516view15:09, 10 December 2021Mkutmonupdated colors
120515view15:07, 10 December 2021Mkutmonupdated layout
120512view12:31, 10 December 2021Nadiapan1
120507view05:56, 10 December 2021Nadiapan1
120503view15:29, 9 December 2021Nadiapan1
120479view23:35, 7 December 2021Nadiapan1
120478view23:25, 7 December 2021Nadiapan1
120460view14:07, 6 December 2021Nadiapan1Modified description
120451view01:09, 3 December 2021Nadiapan1
120450view00:56, 3 December 2021Nadiapan1
120444view22:15, 2 December 2021Nadiapan1
120426view15:06, 30 November 2021Nadiapan1
120425view15:03, 30 November 2021Nadiapan1
120424view15:00, 30 November 2021Nadiapan1
120377view23:23, 29 November 2021EweitzModified title
120290view12:30, 24 November 2021Mkutmonadded missing ref information
120289view12:25, 24 November 2021Mkutmonfix references
120288view12:24, 24 November 2021Mkutmonfix publication references
120287view12:16, 24 November 2021MkutmonOntology Term : 'signaling pathway' added !
120286view12:16, 24 November 2021MkutmonOntology Term : 'pancreatic adenocarcinoma' added !
120285view12:14, 24 November 2021Nadiapan1New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductP31749 (Uniprot-TrEMBL)
AKT2ProteinP31751 (Uniprot-TrEMBL)
AKT3ProteinQ9Y243 (Uniprot-TrEMBL)
CD31 GeneProductENSG00000261371 (Ensembl)
CDH1ProteinENSG00000039068 (Ensembl)
CDH2ProteinENSG00000170558 (Ensembl)
CDH5GeneProductENSG00000179776 (Ensembl)
CDK2ComplexENSG00000123374 (Ensembl)
COL1A1ProteinENSG00000108821 (Ensembl)
CRMP1GeneProductENSG00000072832 (Ensembl)
CTGFProteinENSG00000118523 (Ensembl)
Cell proliferationPathway
EGFRGeneProductENSG00000146648 (Ensembl)
ERKMetaboliteCHEBI:17300 (ChEBI)
EndMTPathway
Epithelial- mesenchymal transition (EMT)Pathway
FAK GeneProductENSG00000169398 (Ensembl)
FARP2GeneProductENSG00000006607 (Ensembl)
FibrosisPathway
GSK3GeneProductENSG00000105723 (Ensembl)
MAPK Pathway
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductMAPK12 (HGNC)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MEKMetaboliteCHEBI:28398 (ChEBI)
MMP2GeneProductENSG00000087245 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MetastasisPathway
MiR-141RnaENSG00000207708 (Ensembl)
Migration, InvasionPathway
NRP1GeneProductENSG00000099250 (Ensembl)
NRP1ProteinO14786 (Uniprot-TrEMBL)
PDGFR MetaboliteCHEBI:133397 (ChEBI)
PI3KGeneProduct
PLXNA4ProteinENSG00000221866 (Ensembl)
SHBGeneProductENSG00000107338 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SNAI1GeneProductENSG00000124216 (Ensembl)
SNAI2GeneProductENSG00000019549 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
VEGFR2GeneProductP17948 (Uniprot-TrEMBL)
ZIP4ProteinA6NDY5 (Uniprot-TrEMBL)
c-metGeneProductENSG00000105976 (Ensembl)
cyclin E MetaboliteCHEBI:82665 (ChEBI)
p130Cas ProteinENSG00000050820 (Ensembl)
p27GeneProductENSG00000111276 (Ensembl)

Annotated Interactions

No annotated interactions

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