HIPK2 in kidney fibrosis (Homo sapiens)
From WikiPathways
Description
This pathway shows the activation of multiple signaling pathways involved in kidney fibrosis, starting from an insult like HIV infection or oxidative stress, through the suppression of SIAH1 and increased expression of HIPK2.
This pathway was adapted from Figure 6i of Jin et. al.
Quality Tags
Ontology Terms
Saving...Bibliography
- Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, Mazloom AR, Chen EY, D'Agati V, Xiong H, Ross MJ, Chen N, Ma'ayan A, He JC; ''A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.''; Nat Med, 2012 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| HIPK2 | GeneProduct | 28996 (Entrez Gene)  | |
| NF-kB signaling | Pathway | WP4562 (WikiPathways) | |
| Notch signaling | Pathway | WP268 (WikiPathways) | |
| SIAH1 | GeneProduct | 6477 (Entrez Gene) | |
| TGF-B signaling | Pathway | WP3874 (WikiPathways) | |
| Wnt / B-catenin signaling | Pathway | WP4150 (WikiPathways) | |
| p53 pathway | Pathway | WP707 (WikiPathways) |
Annotated Interactions
No annotated interactions
