Inflammatory bowel disease signaling (Homo sapiens)

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142, 41, 311114JAK-STAT signaling pathwayTh17 cell differentiationDNADNADNAAntigen processing and presentationDNAInhibition of activated Th2 cellInflammation Inhibition of activated Th1 cellIntestinal wall Th17 lymphocyteCytokine-cytokine receptor interactionMacrophageNKT cell(e.g. Enscherichia Coli, Mycobacterium Avium Paratuberculosis)Ulcerative ColitisTH0 CellINFLAMMATORY BOWEL DISEASELuminal bacteria Treg cell?Th1 lymphocyteToll-like receptor signalling pathwayAPCJAK-STAT signalling pathwayTh2 lymphocyteCrohn's DiseaseTissue injuryBacterial invasionInhibition of IBDantigen antigen STAT4STAT1IL-13 IL12RB1IL-18R-betaNOD2IL21IL23AT-cell receptor signalling pathwayAP1IL22IL-5MHC class 2STAT3IL-2T-betSMAD2TLR2IFNGIL-12FOXP3IL-18RORATLR4TNFATNFIL-6TLR2IFNGIL12RB1IL-5NF-kBTGFBTLR2NFATC1IFNGNOD2STAT3IFNGR1IL-4RAIL-10NF-kBRORytFOXP3TLR5STAT6IL-2RGIL-4TGFB1 IL12RB2IL6IL21RIL-4IL-1IL-13STAT3IL23RIL-10c-MAFIL17IL-4TGFB1GATA3peptidoglycanNOD-like receptor signalling pathwayFlagellinPeptidoglycans LipopolysaccaridesMDP2increase the frequency of Th17 cellsTCRDNADNADNADNADNADNADNADNADNANF-kB


Description

Pathway representing the inflammatory bowel disease showing steps leading to Crohn's disease and ulcerative colitis.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Strober W, Fuss I, Mannon P; ''The fundamental basis of inflammatory bowel disease.''; J Clin Invest, 2007 PubMed Europe PMC Scholia
  2. Guan Q; ''A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease.''; J Immunol Res, 2019 PubMed Europe PMC Scholia
  3. Schmitt H, Neurath MF, Atreya R; ''Role of the IL23/IL17 Pathway in Crohn's Disease.''; Front Immunol, 2021 PubMed Europe PMC Scholia
  4. Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, Kitazume MT, Nakazawa A, Sugita A, Koganei K, Isobe K, Hibi T; ''IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease.''; Gut, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
130805view12:55, 30 May 2024EweitzUse gene symbols
130803view12:35, 30 May 2024EweitzUse gene symbols
130802view12:33, 30 May 2024EweitzLink "Cytokine-cytokine receptor interaction" pathway
129326view14:04, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
128431view17:56, 4 February 2024EweitzOntology Term : 'T-helper 2 cell' added !
128430view17:55, 4 February 2024EweitzOntology Term : 'T-helper 1 cell' added !
128429view17:55, 4 February 2024EweitzOntology Term : 'T-helper 17 cell' added !
128428view17:52, 4 February 2024EweitzOntology Term : 'macrophage' added !
128427view17:52, 4 February 2024EweitzOntology Term : 'colon macrophage' added !
128426view17:51, 4 February 2024EweitzOntology Term : 'naive thymus-derived CD4-positive, alpha-beta T cell' added !
128425view17:51, 4 February 2024EweitzOntology Term : 'lymphocyte' added !
128424view17:50, 4 February 2024EweitzOntology Term : 'professional antigen presenting cell' added !
128388view02:51, 4 February 2024EweitzRefine cell label placement
128387view02:48, 4 February 2024EweitzEconomize layout
128386view01:53, 4 February 2024EweitzOntology Term : 'ulcerative colitis' added !
128385view01:50, 4 February 2024EweitzEconomize layout
128384view01:37, 4 February 2024EweitzEconomize layout
128383view01:29, 4 February 2024EweitzEconomize layout
128382view01:11, 4 February 2024EweitzEconomize layout
128381view00:48, 4 February 2024EweitzEconomize layout
128380view00:33, 4 February 2024EweitzUpgrade two pathway nodes
128370view12:44, 3 February 2024EweitzUpgrade disease nodes: link, color
128369view12:36, 3 February 2024EweitzStandardize case
123858view06:13, 19 August 2022EgonwTyped two datanodes with an Ensembl identifier as Type="GeneProduct"
121825view07:26, 7 March 2022EgonwMade a pathway clickable
121626view10:45, 22 February 2022ImkeGruttersOntology Term : 'Toll-like receptor signaling pathway' added !
121625view10:45, 22 February 2022ImkeGruttersOntology Term : 'interleukin-2 signaling pathway' added !
121624view10:44, 22 February 2022ImkeGruttersOntology Term : 'interleukin-12 family mediated signaling pathway' added !
121623view10:44, 22 February 2022ImkeGruttersOntology Term : 'altered cytokine mediated signaling pathway' added !
121622view10:43, 22 February 2022ImkeGruttersOntology Term : 'signaling pathway involving second messengers' added !
121621view10:36, 22 February 2022ImkeGruttersOntology Term : 'immune system disease' added !
121620view10:34, 22 February 2022ImkeGruttersOntology Term : 'inflammatory bowel disease' added !
121614view09:31, 22 February 2022SusanModified description
121613view09:29, 22 February 2022SusanModified title
121612view09:29, 22 February 2022SusanOntology Term : 'inflammatory bowel disease' added !
121592view17:48, 21 February 2022AndraOntology Term : 'colitis' added !
121591view17:48, 21 February 2022AndraOntology Term : 'Crohn's disease' added !
121590view17:47, 21 February 2022AndraOntology Term : 'colonic disease' added !
121583view15:31, 21 February 2022ZDLechTitle correction
121554view11:02, 21 February 2022JPippiFixed interactions
121553view10:58, 21 February 2022JPippiAddition of literature
121515view16:06, 20 February 2022JPippiAddition of literature, addition/change of some gene product ID's
121512view11:24, 20 February 2022ZDLechNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
IL12RB1GeneProductENSG00000096996 (Ensembl)
IL12RB2GeneProductENSG00000081985 (Ensembl)
AP1GeneProductENSG00000177606 (Ensembl)
FOXP3GeneProductENSG00000049768 (Ensembl)
GATA3GeneProductENSG00000107485 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IFNGR1GeneProductENSG00000027697 (Ensembl)
IL-10GeneProductENSG00000136634 (Ensembl)
IL-12GeneProductENSG00000168811 (Ensembl)
IL-13GeneProductENSG00000169194 (Ensembl)
IL-18GeneProductENSG00000150782 (Ensembl)
IL-18R-betaGeneProductENSG00000115607 (Ensembl)
IL-1GeneProductENSG00000115008 (Ensembl)
IL-2GeneProductENSG00000109471 (Ensembl)
IL-2RGGeneProductENSG00000147168 (Ensembl)
IL-4GeneProductENSG00000113520 (Ensembl)
IL-4RAGeneProductENSG00000077238 (Ensembl)
IL-5GeneProductENSG00000113525 (Ensembl)
IL-6GeneProductENSG00000136244 (Ensembl)
IL12RB1GeneProductENSG00000096996 (Ensembl)
IL17GeneProductENSG00000112116 (Ensembl)
IL21GeneProductENSG00000138684 (Ensembl)
IL21RGeneProductENSG00000103522 (Ensembl)
IL22GeneProductENSG00000127318 (Ensembl)
IL23AGeneProductENSG00000110944 (Ensembl)
IL23RGeneProductENSG00000162594 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
MDPMetaboliteCHEBI:183049 (ChEBI)
MHC class 2ProteinENSG00000204257 (Ensembl)
NF-kBENSG00000109320 (Ensembl)
NFATC1GeneProductENSG00000131196 (Ensembl)
NOD2GeneProductENSG00000167207 (Ensembl)
RORAGeneProductENSG00000069667 (Ensembl)
RORytGeneProductENSG00000143365 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT4GeneProductENSG00000138378 (Ensembl)
STAT6GeneProductENSG00000166888 (Ensembl)
T-betGeneProductENSG00000073861 (Ensembl)
T-cell receptor signalling pathwayPathwayWP69 (WikiPathways)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBGeneProductENSG00000105329 (Ensembl)
TLR2GeneProductENSG00000137462 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR5GeneProductENSG00000187554 (Ensembl)
TNFAGeneProductENSG00000232810 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
c-MAFGeneProductENSG00000178573 (Ensembl)
peptidoglycanMetaboliteCHEBI:8005 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5198"
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