Glucose metabolism in triple-negative breast cancer cells (Homo sapiens)
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Description
Glucose metabolism in triple-negative breast cancer cells. The glycolytic pathway is significantly upregulated in triple-negative breast tumors. The genes coding the key glycolytic enzymes are overexpressed in triple-negative breast tumors. TCA, tricarboxylic acid cycle; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; F1,6P, fructose-1,6-bisphosphate; PEP, phosphoenolpyruvate; OAA, oxaloacetate; α-KG, α-ketoglutarate; GLUT, glucose transporter; HK, hexokinase; PFK, phosphofructokinase; PKM2, pyruvate kinase isozyme type 2; LDHA, lactate dehydrogenase A; MCT1, monocarboxylate transporter 1; PDK1, pyruvate dehydrogenase kinase 1; PDH, pyruvate dehydrogenase.
Quality Tags
Ontology Terms
Bibliography
- Avanzato D, Pupo E, Ducano N, Isella C, Bertalot G, Luise C, Pece S, Bruna A, Rueda OM, Caldas C, Di Fiore PP, Sapino A, Lanzetti L; ''High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis.''; Cancer Res, 2018 PubMed Europe PMC Scholia
- Sun X, Wang M, Yu X, Guo J, Sun T, Li X, Yao L, Dong H, Xu Y; ''Metabolic Reprogramming in Triple-Negative Breast Cancer.''; Front Oncol, 2020 PubMed Europe PMC Scholia
- Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey B, Hay N; ''Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer.''; Cancer Cell, 2013 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Acetyl CoA | Metabolite | ||
Fructose-6-phosphate | Metabolite | CHEBI:15946 (ChEBI) | |
GLUT1 | GeneProduct | 6513 (Entrez Gene) | |
Glucose | Metabolite | Q37525 (Wikidata) | |
Glycolysis | Pathway | ||
HK | GeneProduct | 3098 (Entrez Gene) | |
LDHA | GeneProduct | ENSG00000134333 (Ensembl) | |
Lactate | Metabolite | ||
MCT1 | GeneProduct | 6566 (Entrez Gene) | |
NADPH | Metabolite | ||
PDH | GeneProduct | 54704 (Entrez Gene) | |
PDK1 | GeneProduct | ENSG00000152256 (Ensembl) | |
PFKP | GeneProduct | 5214 (Entrez Gene) | |
PKM2 | GeneProduct | ||
Pentose phosphate pathway | Pathway | WP134 (WikiPathways) | |
Pyruvate | Metabolite | ||
Respiratory chain | Pathway | ||
TCA cycle | Pathway | WP78 (WikiPathways) | |
fructose-1,6-bisphosphate | Metabolite | ||
glucose-6-phosphate | Metabolite | Q32778969 (Wikidata) | |
phosphoenolpyruvate | Metabolite | ||
pyruvate | Metabolite | CHEBI:15361 (ChEBI) |
Annotated Interactions
No annotated interactions