Thyroid hormone imbalance leading to neurodevelopmental abnormalities (Homo sapiens)

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Description

Quality Tags

Ontology Terms

Bibliography

1. Sauer UG, Asiimwe A, Botham PA, Charlton A, Hallmark N, Jacobi S, Marty S, Melching-Kollmuss S, Palha JA, Strauss V, van Ravenzwaay B, Swaen G; ''Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments?''; Crit Rev Toxicol, 2020 PubMed Europe PMC Scholia
2. Marty S, Beekhuijzen M, Charlton A, Hallmark N, Hannas BR, Jacobi S, Melching-Kollmuss S, Sauer UG, Sheets LP, Strauss V, Urbisch D, Botham PA, van Ravenzwaay B; ''Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments?''; Crit Rev Toxicol, 2021 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	134542	view	21:16, 22 July 2024	Eweitz	Ontology Term : 'oligodendrocyte' added !
	134541	view	21:16, 22 July 2024	Eweitz	Ontology Term : 'GABAergic interneuron' added !
	134540	view	21:15, 22 July 2024	Eweitz	Ontology Term : 'thyroid hormone biosynthetic pathway' added !
	134539	view	18:35, 22 July 2024	Egonw	Fixed a datasource
	128159	view	17:07, 28 January 2024	Eweitz	Modified description
	128158	view	17:06, 28 January 2024	Eweitz	Refine node padding, add space after colons, standardize case
	128157	view	17:02, 28 January 2024	Eweitz	Modified title
	127806	view	21:23, 17 December 2023	Marvin M2	Modified description
	127805	view	21:22, 17 December 2023	Marvin M2
	127804	view	21:18, 17 December 2023	Marvin M2	graphical updates
	127291	view	14:34, 4 September 2023	Marvin M2	Updated layout, added chain of KEs
	126475	view	17:27, 4 May 2023	CMalyar	Modified title
	125574	view	13:23, 28 February 2023	Marvin M2	Added references
	125573	view	13:19, 28 February 2023	Marvin M2	Ontology Term : 'thyroid hormone signaling pathway' added !
	124846	view	21:03, 14 December 2022	Eweitz	Modified title
	124834	view	19:38, 13 December 2022	Marvin M2
	124833	view	19:36, 13 December 2022	Marvin M2	alignment changes
	122991	view	13:39, 10 June 2022	CMalyar	Fixed interactions
	122990	view	14:06, 9 June 2022	CMalyar	Pathway interactions fixed
	122989	view	14:04, 9 June 2022	CMalyar	Fixed interaction arrows
	122983	view	08:01, 9 June 2022	CMalyar	Manual identifiers of key events from AOP-Wiki
	122980	view	20:03, 8 June 2022	CMalyar	Fixed pathway identifiers
	122979	view	19:57, 8 June 2022	CMalyar	Structural changes
	122671	view	07:59, 29 April 2022	CMalyar
	122655	view	12:58, 26 April 2022	CMalyar
	122654	view	11:03, 26 April 2022	CMalyar	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
CaMKK2 signaling pathway	Pathway
KE277: Decrease thyroid hormone synthesis
KE279: Thyroperoxidase inhibition
KE280:Decreased T4 in neuronal tissue
KE281:Decreased T4 in serum
KE319: loss of cochlear function
KE341: Learning and memory impairment
KE381:Reduced levels of BDNF
KE385: Decreased synaptogenesis
KE386: Decreased neuronal network function
KE424: NIS inhibition
KE425: Decrease of Thyroidal Iodide
KE42: Decreased cognitive function
KE756:Altered hippocampal gene expression
KE757: Altered hippocampal anatomy
KE758: Altered hippocampal physiology
KE851: Decreased GABAergic interneurons
Pathway	Pathway
Thyroid hormone biosynthesis pathway	Pathway
Thyroid hormone biosynthesis pathway	Pathway

Annotated Interactions

No annotated interactions