Hippocampal synaptogenesis and neurogenesis (Homo sapiens)

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3CaMKII CytokinesGrowth factors Regulation of multiplepostsynaptic and presynaptic proteins through phosphorylation(e.g. neurotransmitter synthesis, cytoskeletal regulation, calcium channelregulation) DRD1 Thyroxine (T4)ATPCa2+PRKCA Voltage-gated Ca2+ channel AMPA NMDA cAMPCREB1Ca2+Ca2+Ca2+Ca2+Ca2+Ca2+Na+K+CALM1CAMK2A CAMK2BCAMKK1 CAMKK2CaMKKCAMK4 CAMK4 PRKCATrkBMAPK14MAPK/ERKRSKRSKRPS6KA5Adult hippocampal neurogenesis Memory cognition(spatial memory, recognition memory, fear memory,pattern discrimination)Triiodothyronine (T3)Thyroxine (T4)DIO2NRXN1 2NRXN2 2NRXN3 SYT2 22SYT122Ca2+ dependent synaptic remodelingBDNF 2NCAM1 PRLBCL2NGF CCND2 Ca2+ dependent expression of neurogenic genes HNRNPLHippocampal neuron1PPARGC1ARegulation of calcium homeostasisin neuronal cells. Influences brain development11


Description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Krebs J; ''The Influence of Thyroid Hormone on Ca2+Signaling Pathways During Embryonal Development.''; Curr Top Med Chem, 2021 PubMed Europe PMC Scholia
  2. Ortega-Martínez S; ''A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis.''; Front Mol Neurosci, 2015 PubMed Europe PMC Scholia
  3. Krebs J; ''Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway.''; Biochim Biophys Acta Mol Cell Res, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134518view12:39, 22 July 2024EweitzImprove contrast for better readability
134517view12:38, 22 July 2024EweitzImprove contrast for better readability
123335view19:22, 16 July 2022AlexanderPicoOntology Term : 'hippocampal neuron' added !
123334view19:22, 16 July 2022AlexanderPicoOntology Term : 'signaling pathway' added !
123333view19:22, 16 July 2022AlexanderPicoOntology Term : 'regulatory pathway' added !
123332view19:22, 16 July 2022AlexanderPicoOntology Term : 'synaptic differentiation pathway' added !
123331view19:21, 16 July 2022AlexanderPicoOntology Term : 'signaling pathway pertinent to development' added !
123330view19:19, 16 July 2022AlexanderPicoModified title
123329view19:19, 16 July 2022AlexanderPicoModified description
122750view09:33, 9 May 2022CMalyarFixed unconnected arrow
122749view09:32, 9 May 2022CMalyarModified arrow
122748view09:25, 9 May 2022CMalyarAdded anchor
122732view20:19, 6 May 2022CMalyarModified identifiers
122731view20:19, 6 May 2022CMalyarModified identifiers
122730view13:38, 6 May 2022CMalyarAddition of genes downstream of T3 (Neurexin, SYT2,SYT12, PMCA1a, HNRNPL). New references.
122705view10:08, 4 May 2022EgonwNormalized the Ensembl data source
122699view14:35, 3 May 2022CMalyar
122698view14:35, 3 May 2022CMalyar
122697view14:33, 3 May 2022CMalyarNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AMPA ComplexR-HSA-9620484 (Reactome)
ATPMetabolite30616 (ChEBI)
BCL2ProteinENSG00000171791 (Ensembl)
BDNF ProteinENSG00000176697 (Ensembl)
CALM1 ProteinENSG00000198668 (Ensembl)
CAMK2A ProteinENSG00000070808 (Ensembl)
CAMK2B ProteinENSG00000058404 (Ensembl)
CAMK4 ProteinENSG00000152495 (Ensembl)
CAMK4 ProteinHGNC:1464 (HGNC)
CAMKK1 ProteinENSG00000004660 (Ensembl)
CAMKK2 ProteinENSG00000110931 (Ensembl)
CCND2 ProteinENSG00000118971 (Ensembl)
CREB1ProteinP16220 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DIO2 ProteinENSG00000211448 (Ensembl)
DRD1 GeneProductENSG00000184845 (Ensembl)
HNRNPL ProteinENSG00000104824 (Ensembl)
K+MetaboliteCHEBI:29103 (ChEBI)
MAPK/ERK ProteinENSG00000100030 (Ensembl)
MAPK14ProteinENSG00000112062 (Ensembl)
NCAM1 ProteinENSG00000149294 (Ensembl)
NGF ProteinENSG00000134259 (Ensembl)
NMDA ComplexR-HSA-884990 (Reactome)
NRXN1 ProteinENSG00000179915 (Ensembl)
NRXN2 ProteinENSG00000110076 (Ensembl)
NRXN3 ProteinENSG00000021645 (Ensembl)
Na+MetaboliteCHEBI:29101 (ChEBI)
PPARGC1AProteinENSG00000109819 (Ensembl)
PRKCA ProteinENSG00000154229 (Ensembl)
PRKCA ProteinHGNC:9393 (HGNC)
PRLProteinENSG00000172179 (Ensembl)
RPS6KA5ProteinENSG00000100784 (Ensembl)
RSK ProteinENSG00000117676 (Ensembl)
SYT12ProteinENSG00000173227 (Ensembl)
SYT2 ProteinENSG00000143858 (Ensembl)
Thyroxine (T4)MetaboliteHMDB0000248 (HMDB)
Triiodothyronine (T3)Metabolite5707 (Chemspider)
TrkBGeneProductW8VY28 (Uniprot-TrEMBL)
Voltage-gated Ca2+ channel ComplexR-HSA-210378 (Reactome)
cAMPMetabolite17489 (ChEBI)

Annotated Interactions

No annotated interactions

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