Thyroid hormone imbalance leading to neurodevelopmental abnormalities (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Sauer UG, Asiimwe A, Botham PA, Charlton A, Hallmark N, Jacobi S, Marty S, Melching-Kollmuss S, Palha JA, Strauss V, van Ravenzwaay B, Swaen G; ''Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments?''; Crit Rev Toxicol, 2020 PubMed Europe PMC Scholia
2. Marty S, Beekhuijzen M, Charlton A, Hallmark N, Hannas BR, Jacobi S, Melching-Kollmuss S, Sauer UG, Sheets LP, Strauss V, Urbisch D, Botham PA, van Ravenzwaay B; ''Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments?''; Crit Rev Toxicol, 2021 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	134542	view	21:16, 22 July 2024	Eweitz	Ontology Term : 'oligodendrocyte' added !
	134541	view	21:16, 22 July 2024	Eweitz	Ontology Term : 'GABAergic interneuron' added !
	134540	view	21:15, 22 July 2024	Eweitz	Ontology Term : 'thyroid hormone biosynthetic pathway' added !
	134539	view	18:35, 22 July 2024	Egonw	Fixed a datasource
	128159	view	17:07, 28 January 2024	Eweitz	Modified description
	128158	view	17:06, 28 January 2024	Eweitz	Refine node padding, add space after colons, standardize case
	128157	view	17:02, 28 January 2024	Eweitz	Modified title
	127806	view	21:23, 17 December 2023	Marvin M2	Modified description
	127805	view	21:22, 17 December 2023	Marvin M2
	127804	view	21:18, 17 December 2023	Marvin M2	graphical updates
	127291	view	14:34, 4 September 2023	Marvin M2	Updated layout, added chain of KEs
	126475	view	17:27, 4 May 2023	CMalyar	Modified title
	125574	view	13:23, 28 February 2023	Marvin M2	Added references
	125573	view	13:19, 28 February 2023	Marvin M2	Ontology Term : 'thyroid hormone signaling pathway' added !
	124846	view	21:03, 14 December 2022	Eweitz	Modified title
	124834	view	19:38, 13 December 2022	Marvin M2
	124833	view	19:36, 13 December 2022	Marvin M2	alignment changes
	122991	view	13:39, 10 June 2022	CMalyar	Fixed interactions
	122990	view	14:06, 9 June 2022	CMalyar	Pathway interactions fixed
	122989	view	14:04, 9 June 2022	CMalyar	Fixed interaction arrows
	122983	view	08:01, 9 June 2022	CMalyar	Manual identifiers of key events from AOP-Wiki
	122980	view	20:03, 8 June 2022	CMalyar	Fixed pathway identifiers
	122979	view	19:57, 8 June 2022	CMalyar	Structural changes
	122671	view	07:59, 29 April 2022	CMalyar
	122655	view	12:58, 26 April 2022	CMalyar
	122654	view	11:03, 26 April 2022	CMalyar	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
BDNF signaling pathway	Pathway	WP2380 (WikiPathways)
CaMKK2 signaling pathway	Pathway	WP5231 (WikiPathways)
GABA receptor signaling pathway	Pathway	WP4159 (WikiPathways)
KE277: Decrease thyroid hormone synthesis
KE279: Thyroperoxidase inhibition
KE280:Decreased T4 in neuronal tissue
KE281:Decreased T4 in serum
KE319: loss of cochlear function
KE341: Learning and memory impairment
KE381:Reduced levels of BDNF
KE385: Decreased synaptogenesis
KE386: Decreased neuronal network function
KE424: NIS inhibition
KE425: Decrease of Thyroidal Iodide
KE42: Decreased cognitive function
KE756:Altered hippocampal gene expression
KE757: Altered hippocampal anatomy
KE758: Altered hippocampal physiology
KE851: Decreased GABAergic interneurons
Thyroid hormone biosynthesis pathway	Pathway	WP1981 (WikiPathways)

Annotated Interactions

No annotated interactions