Comprehensive IL-17A signaling (Mus musculus)

From WikiPathways

Revision as of 21:15, 30 October 2022 by AlexanderPico (Talk | contribs)
Jump to: navigation, search
1DissociationChemokine ligands ProteinHuman bronchial epithelial (HBE) cellsTransforming growth factor beta signalingAlveolar basal epithelial A549 cells IL-17A mediated pulmonary SMAD- dependent and non-dependent mechanism during acute lung injury in vivoInflammation, apoptosis, and migration InterleukinsBleomycin-induced pulmonary fibrotic mice modelPulmonary inflammation and fibrosis Minichromosome maintenance (MCM) proteins invovled in DNA replicationCOL5A2Cxcl5CCL2 Nucks1CSF3PlauUpf1TGFB1MUC5ACCacybpOrc1Srpk2PlaurZmpste24Acta1Serpine1Cxcl1VCANIL-6IL-11CrebbpEgfrPole3Cxcl12AtrxOrc2PcnaCXCL1Dhx9Ccl3CXCL8Cdc42ACTA2Samhd1Casp3Rbbp4Ccl4HSPG2Parp1Rac1Ccl5Fn1NaspPuraTNFIL-10COL3A1Npm1LIFCdc42CXCL2Sqstm1Acta2Igf1Acta2Map1lc3bBaffFbn1Bcl2IL1BHspa1bSnai1Mki67Mcm7Adh1Hmgb1Smad6Col1a1PdgfbHbb-bh1Sod2Stat1Y701Plch1mTORS2448CXCL5Smad2S465S467P53IL17RAPrkacbMAPK1PPRKAA1MAPK3Anxa6PPlauIl1bPtgs2CXCL6Mmp3PI3KCAY199Y458Becn1Akt1Stat1IL17AS473Ccn2IL17RARac1MAPK14MtorMylkGng12Uggt1Stat3Il6Y705RELAMcm5S536Casp3PdgfaRab10Serpine1RELAS536Cpne1NFKB1Map1lc3aNFKBIAC3Arpc2Smad7 CXCL1RELAEgfrNFKB1Y1068BECN1 NFKBIAPik3c3CFBActa2Cxcl1Hbb-b2Col1a1BCL2Psmc6PlaurRelaMcm4Mcm6GSK3BParticulate matter (PM2.5)S9CXCL3Bleomycin induced IL-17A activationMcm2Tgfb1Ppp1r14bBlmhSnai2IL8Experimental silica treatment in miceP53RhoaAutophagyPak3GRK5Il1bIL6C7 Mmp14Arpc3Gap43Mcm3Smad3Degrease kinase activity GSK3BS423S425mTORInhibit autophagy in pulmonary fibrosis IL17AS2448PIK3CAPActa2Inflammatory neutrophils in the bronchoalveolar space Rras2Arpc5Atox1Hyou1FibrosisPon3IL-17A stimulationAngpt1IL-17ACxcl12 IL17RAMmp9Cxcl2Hbb-b1Tgfb1Smad2S465S467Smad3S425S423Jak2Y1007Y1008Jak1Y1035Y1034Stat3Y705Acute lung injurySTAT1/3 mediated transcriptionalregulationMAPK1PMAPK3PmTORStat3IL-17AIL17RAJak2Y1007Y1008Jak1Y1034Y1035P53PAkt1PMAPK14Y185T183Bleomycin induced IL-17A activationUnilateral Ureteral Obstruction (UUO) injuryIL-17A stimulationIL-17AIL17RANFKB1NFKBIAPChronic airway diseasesIL-17A stimulationReceptorProteinmRNALigand Inhibition Leads to through multiple reactionsLEGEND IL-17A stimulation Bleomycin induced IL-17A activationSmad3S425S423DissociationStat3Y705Stat1Y701Stat3Y705 Translocation Nucleus Cytoplasm Plasma membraneCYPMNU ExtracellularECGene/ProteinGene/Protein Upregulation Downregulation PhosphorylationDissociationNUCYNUCYNUCYNUCYActivationGram-negative bacterial pneumonia infection Airway epithelial cells Proliferation of asthmatic fibrocytes AsthmaIL-10ACTA2Extracellular matrix deposition and neovascularization Apoptosis and injury Bleomycin induced miceDegradation of BCL-2Human lung epithelial cellsBCL2S70Renal fibrosisSilicosis lung inflammation in miceSnai1Col1a1Snai2Tjp1Cdh1Epithelial-mesenchymal transition (EMT) markersHuman primary small airway epithelial cellsMouse alveolar epithelial (MLE-12) cells Jak2Jak1PPParticulate matter (PM2.5) stimulationExperimental silica treatment in miceP


Description

Schematic representation of IL-17A signaling pathway

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Rex DAB, Dagamajalu S, Gouda MM, Suchitha GP, Chanderasekaran J, Raju R, Prasad TSK, Bhandary YP; ''A comprehensive network map of IL-17A signaling pathway.''; J Cell Commun Signal, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126495view21:40, 9 May 2023Khanspersadded missing groups, fixed interactions, converted interactions in legend to graphical lines
126212view09:41, 16 April 2023EgonwLicense is CCZero
124849view21:41, 14 December 2022EweitzModified title
124477view21:23, 30 October 2022AlexanderPicoModified description
124476view21:22, 30 October 2022AlexanderPicomore xrefs
124475view21:15, 30 October 2022AlexanderPicoremoved off-map nodes; added ref
124474view21:13, 30 October 2022AlexanderPicocompleted xrefs; fixed legend to use labels
123976view10:33, 9 September 2022EweitzModified title
123802view18:04, 15 August 2022KhanspersOntology Term : 'interleukin-17 family mediated signaling pathway' added !
123801view18:04, 15 August 2022KhanspersOntology Term : 'signaling pathway' added !
123125view04:40, 5 July 2022EgonwWorked on the data sources
123092view08:08, 29 June 2022Rex D A BAnnotations
123091view07:35, 29 June 2022Rex D A BAlignment
123090view06:32, 28 June 2022Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA2GeneProduct59 (Entrez Gene)
Acta1GeneProduct11459 (Entrez Gene)
Acta2GeneProduct11475 (Entrez Gene)
Adh1GeneProduct11522 (Entrez Gene)
Akt1GeneProduct207 (Entrez Gene)
Akt1ProteinP31750 (Uniprot-TrEMBL)
Angpt1GeneProductENSMUSG00000022309 (Ensembl)
Anxa6GeneProduct11749 (Entrez Gene)
Arpc2GeneProduct76709 (Entrez Gene)
Arpc3GeneProduct56378 (Entrez Gene)
Arpc5GeneProduct67771 (Entrez Gene)
Atox1GeneProduct11927 (Entrez Gene)
AtrxProteinQ61687 (Uniprot-TrEMBL)
BCL2ProteinP10415.2 (Uniprot-TrEMBL)
BECN1 ProteinQ14457.2 (Uniprot-TrEMBL)
BaffGeneProduct24099 (Entrez Gene)
Bcl2ProteinP10417 (Uniprot-TrEMBL)
Becn1ProteinO88597 (Uniprot-TrEMBL)
BlmhGeneProduct104184 (Entrez Gene)
C3GeneProduct12266 (Entrez Gene)
C7 GeneProduct109828 (Entrez Gene)
CCL2 ProteinP13500 (Uniprot-TrEMBL)
CFBGeneProduct629 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
COL5A2GeneProduct1290 (Entrez Gene)
CSF3ProteinP09919 (Uniprot-TrEMBL)
CXCL1GeneProduct2919 (Entrez Gene)
CXCL1ProteinP09341 (Uniprot-TrEMBL)
CXCL2GeneProduct2920 (Entrez Gene)
CXCL3GeneProduct2921 (Entrez Gene)
CXCL5GeneProduct20311 (Entrez Gene)
CXCL6GeneProduct6372 (Entrez Gene)
CXCL8ProteinP10145 (Uniprot-TrEMBL)
CacybpProteinQ9CXW3 (Uniprot-TrEMBL)
Casp3GeneProduct12367 (Entrez Gene)
Casp3ProteinP05122 (Uniprot-TrEMBL)
Ccl3GeneProduct20302 (Entrez Gene)
Ccl4GeneProduct20303 (Entrez Gene)
Ccl5GeneProduct20304 (Entrez Gene)
Ccn2GeneProduct14219 (Entrez Gene)
Cdc42GeneProduct12540 (Entrez Gene)
Cdc42ProteinP60766 (Uniprot-TrEMBL)
Cdh1ProteinP09803 (Uniprot-TrEMBL)
Col1a1GeneProduct12842 (Entrez Gene)
Col1a1ProteinP02452 (Uniprot-TrEMBL)
Cpne1GeneProduct266692 (Entrez Gene)
CrebbpGeneProductP45481 (Uniprot-TrEMBL)
Cxcl1GeneProduct14825 (Entrez Gene)
Cxcl12 ProteinP40224 (Uniprot-TrEMBL)
Cxcl12GeneProduct20315 (Entrez Gene)
Cxcl2GeneProduct20310 (Entrez Gene)
Cxcl5GeneProduct20311 (Entrez Gene)
Dhx9ProteinO70133 (Uniprot-TrEMBL)
EgfrProteinQ01279 (Uniprot-TrEMBL)
Fbn1GeneProduct14118 (Entrez Gene)
Fn1GeneProduct14268 (Entrez Gene)
GRK5GeneProduct2869 (Entrez Gene)
GSK3BProteinP49841 (Uniprot-TrEMBL)
Gap43GeneProduct14432 (Entrez Gene)
Gng12GeneProduct14701 (Entrez Gene)
HSPG2GeneProduct3339 (Entrez Gene)
Hbb-b1GeneProduct15129 (Entrez Gene)
Hbb-b2GeneProduct15130 (Entrez Gene)
Hbb-bh1GeneProduct15132 (Entrez Gene)
Hmgb1GeneProduct15289 (Entrez Gene)
Hspa1bGeneProduct15511 (Entrez Gene)
Hyou1GeneProduct12282 (Entrez Gene)
IL-10ProteinP22301 (Uniprot-TrEMBL)
IL-11ProteinP20809 (Uniprot-TrEMBL)
IL-17AGeneProduct3605 (Entrez Gene)
IL-6ProteinP05231 (Uniprot-TrEMBL)
IL17AGeneProduct3605 (Entrez Gene)
IL17RAGeneProduct23765 (Entrez Gene)
IL1BGeneProductP01584.2 (Uniprot-TrEMBL)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct20309 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Il1bGeneProduct16176 (Entrez Gene)
Il1bGeneProductP10749 (Uniprot-TrEMBL)
Il6GeneProduct16193 (Entrez Gene)
Jak1ProteinP23458 (Uniprot-TrEMBL)
Jak1ProteinP52332 (Uniprot-TrEMBL)
Jak2ProteinO60674 (Uniprot-TrEMBL)
Jak2ProteinQ62120 (Uniprot-TrEMBL)
LIFProteinP15018 (Uniprot-TrEMBL)
MAPK14GeneProduct1432 (Entrez Gene) p38
MAPK14ProteinQ16539 (Uniprot-TrEMBL) p38
MAPK1GeneProduct5594 (Entrez Gene) p38
MAPK1ProteinP28482 (Uniprot-TrEMBL) p38
MAPK3GeneProduct5595 (Entrez Gene)
MAPK3ProteinP27361 (Uniprot-TrEMBL)
MUC5ACGeneProduct4586 (Entrez Gene)
Map1lc3aProteinQ91VR7 (Uniprot-TrEMBL)
Map1lc3bProteinQ9CQV6 (Uniprot-TrEMBL)
Mcm2ProteinP97310 (Uniprot-TrEMBL)
Mcm3ProteinP25206 (Uniprot-TrEMBL)
Mcm4Protein17217 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm6ProteinP97311 (Uniprot-TrEMBL)
Mcm7GeneProductQ61881 (Uniprot-TrEMBL)
Mki67GeneProduct17345 (Entrez Gene)
Mmp14GeneProduct17387 (Entrez Gene)
Mmp3GeneProduct17392 (Entrez Gene)
Mmp9GeneProduct17395 (Entrez Gene)
MtorGeneProduct56717 (Entrez Gene)
MylkGeneProduct107589 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NFKBIAGeneProduct4792 (Entrez Gene)
NaspProteinQ99MD9 (Uniprot-TrEMBL)
Npm1ProteinQ61937 (Uniprot-TrEMBL)
Nucks1ProteinQ80XU3 (Uniprot-TrEMBL)
Orc1ProteinQ9Z1N2 (Uniprot-TrEMBL)
Orc2ProteinQ60862 (Uniprot-TrEMBL)
P53GeneProduct22059 (Entrez Gene)
P53ProteinP04637 (Uniprot-TrEMBL)
PI3KCAProtein5290 (Entrez Gene)
PIK3CAGeneProductPIK3CA
PRKAA1ProteinQ13131 (Uniprot-TrEMBL)
Pak3GeneProduct18481 (Entrez Gene)
Parp1ProteinP11103 (Uniprot-TrEMBL)
PcnaProteinP17918 (Uniprot-TrEMBL Gene)
PdgfaGeneProduct18590 (Entrez Gene)
PdgfbGeneProduct18591 (Entrez Gene)
Pik3c3ProteinQ6PF93 (Uniprot-TrEMBL)
PlauGeneProduct18792 (Entrez Gene)
PlauProteinP06869 (Uniprot-TrEMBL)
PlaurGeneProduct18793 (Entrez Gene)
PlaurProteinP35456 (Uniprot-TrEMBL)
Plch1GeneProduct269437 (Entrez Gene)
Pole3ProteinQ9JKP7 (Uniprot-TrEMBL)
Pon3GeneProductENSMUSG00000029759 (Ensembl)
Ppp1r14bGeneProduct18938 (Entrez Gene)
PrkacbGeneProduct18749 (Entrez Gene)
Psmc6GeneProduct67089 (Entrez Gene)
Ptgs2GeneProduct19225 (Entrez Gene)
PuraProteinP42669 (Uniprot-TrEMBL)
RELAProteinQ04206 (Uniprot-TrEMBL)
Rab10GeneProduct19325 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Rac1ProteinP63001 (Uniprot-TrEMBL)
Rbbp4ProteinQ60972 (Uniprot-TrEMBL)
RelaGeneProduct19697 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
Rras2GeneProduct66922 (Entrez Gene)
Samhd1ProteinQ60710 (Uniprot-TrEMBL)
Serpine1GeneProduct66870 (Entrez Gene)
Serpine1ProteinP05121 (Uniprot-TrEMBL)
Smad2Protein17126 (Entrez Gene)
Smad2ProteinQ62432 (Uniprot-TrEMBL)
Smad3Protein17127 (Uniprot-TrEMBL)
Smad3ProteinQ8BUN5 (Uniprot-TrEMBL)
Smad6ProteinO35182 (Uniprot-TrEMBL)
Smad7 ProteinO35253 (Uniprot-TrEMBL)
Snai1ProteinQ02085 (Uniprot-TrEMBL)
Snai2ProteinP97469 (Uniprot-TrEMBL)
Sod2GeneProduct20656 (Entrez Gene)
Sqstm1ProteinQ64337 (Uniprot-TrEMBL)
Srpk2ProteinO54781 (Uniprot-TrEMBL)
Stat1GeneProduct20846 (Entrez Gene)
Stat1ProteinP42225 (Uniprot-TrEMBL)
Stat3ProteinP42227 (Uniprot-TrEMBL)
TGFB1GeneProductTGFB1
TNFProteinP01375 (Uniprot-TrEMBL)
Tgfb1ProteinP04202 (Uniprot-TrEMBL)
Tjp1ProteinP39447 (Uniprot-TrEMBL)
Uggt1GeneProduct320011 (Entrez Gene)
Upf1ProteinQ9EPU0 (Uniprot-TrEMBL)
VCANGeneProduct1462 (Entrez Gene)
Zmpste24ProteinQ80W54 (Uniprot-TrEMBL)
mTORProteinP42345.1 (Uniprot-TrEMBL)
mTORProteinQ9JLN9 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5242"
Personal tools