Sialylation (Homo sapiens)

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1GlycoconjugateGolgi UDP-N-acetyl-alpha-D-glucosaminealdehydo-N-acetyl-D-mannosamine 6-phosphateCMP-N-acetyl-beta-neuraminic acidGNENANSNANPCMASSLC35A1N-acetyl-D-mannosamineN-acetylneuraminic acid 9-phosphateN-acetylneuraminic acidCMP-N-acetyl-beta-neuraminic acidGlucoseSialylated glycoproteinNucleusSialyltransferase


Description

This pathway describes the biosynthesis, activation and transfer of the sialic acid Neu5Ac to glycoproteins. Sialic acids are acidic sugar molecules that commonly occur as the terminal sugar as part of glycoproteins and glycolipids on the surface of cells. Sialylated conjugates play important roles in many processes, including cell recognition and signaling, neuronal development, cancer metastasis and bacterial or viral infection. The two most commonly mammalian sialic acids are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc).

This pathway was modeled based on figure 1 from Zhou et al.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Zhou X, Yang G, Guan F; ''Biological Functions and Analytical Strategies of Sialic Acids in Tumor.''; Cells, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134713view12:28, 26 July 2024EweitzStandardize case
126030view17:35, 28 March 2023Khanspersgolgi position
126027view17:25, 28 March 2023Khanspersupdate centerx for golgi
126026view17:07, 28 March 2023Khanspersnew golgi
125996view18:19, 24 March 2023KhanspersOntology Term : 'regulatory pathway' added !
125995view18:19, 24 March 2023KhanspersOntology Term : 'protein modification pathway' added !
125988view18:10, 23 March 2023KhanspersModified description
125987view18:10, 23 March 2023Khansperslatest - updated xrefs
125944view22:20, 22 March 2023KhanspersModified description
125943view22:04, 22 March 2023KhanspersOntology Term : 'protein modification pathway' added !
125942view22:00, 22 March 2023KhanspersModified description
125941view22:00, 22 March 2023KhanspersOntology Term : 'regulatory pathway' added !
125940view21:55, 22 March 2023KhanspersGolgi size
125939view21:54, 22 March 2023KhanspersGolgi size
125938view21:52, 22 March 2023Khanspersupdated to latest
120551view20:01, 14 December 2021KhanspersModified description
120550view19:58, 14 December 2021KhanspersOntology Term : 'regulatory pathway' added !
120549view19:29, 14 December 2021KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
UDP-N-acetyl-alpha-D-glucosamineMetaboliteCHEBI:16264 (ChEBI)
CMASGeneProductENSG00000111726 (Ensembl)
CMP-N-acetyl-beta-neuraminic acidMetaboliteCHEBI:16556 (ChEBI)
GNEGeneProductENSG00000159921 (Ensembl)
GlucoseMetaboliteCHEBI:17234 (ChEBI)
N-acetyl-D-mannosamineMetaboliteCHEBI:63153 (ChEBI)
N-acetylneuraminic acid 9-phosphateMetaboliteCHEBI:27438 (ChEBI)
N-acetylneuraminic acidMetaboliteCHEBI:17012 (ChEBI)
NANPGeneProductENSG00000170191 (Ensembl)
NANSGeneProductENSG00000095380 (Ensembl)
SLC35A1GeneProductENSG00000164414 (Ensembl)
aldehydo-N-acetyl-D-mannosamine 6-phosphateMetaboliteCHEBI:28273 (ChEBI)

Annotated Interactions

No annotated interactions

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