Iron-sulfur cluster biogenesis (Homo sapiens)

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21Mitochondrial Fe-S proteinsFeLYRM4e-ISCUL-cysteineNFS1[4Fe-4S] clusterSFXNFDX1FDXRABCB7HSPA9HSCBGLRX5NUBP2NUBP1NARFCIAO1CIAO2BFXNNFU1NFS1ISCUFeFeFe[4Fe-4S] clusterCytosolicFe-S proteinsISCU


Description

This pathway describes the biogenesis of iron-sulphur clusters. Iron-sulphur clusters bind to proteins and are essential components of respiratory electron transfer complexes as well as many other biological processes. This pathway was modeled based on Fig 2a from Rouault and Tong.

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Ontology Terms

 

Bibliography

  1. Friemel M, Marelja Z, Li K, Leimkühler S; ''The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1.''; Biochemistry, 2017 PubMed Europe PMC Scholia
  2. Rouault TA, Tong WH; ''Iron-sulfur cluster biogenesis and human disease.''; Trends Genet, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
125997view18:20, 24 March 2023KhanspersOntology Term : 'regulatory pathway' added !
125989view18:12, 23 March 2023KhanspersModified description
125986view18:06, 23 March 2023Khansperslatest - updated xrefs
125985view18:04, 23 March 2023KhanspersReverted to version '17:47, 23 March 2023' by Khanspers
125984view18:03, 23 March 2023Khansperslatest - updated xrefs
125983view17:47, 23 March 2023KhanspersModified description
125982view17:31, 23 March 2023KhanspersModified description
125981view17:31, 23 March 2023Khanspersupdate with latest
120555view00:20, 15 December 2021KhanspersOntology Term : 'iron-sulfur cluster protein biogenesis pathway' added !
120554view00:19, 15 December 2021KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCB7GeneProductENSG00000131269 (Ensembl)
CIAO1GeneProductENSG00000144021 (Ensembl)
CIAO2BGeneProduct51647 (Entrez Gene)
FDX1GeneProduct2230 (Entrez Gene)
FDXRGeneProduct2232 (Entrez Gene)
FXNGeneProduct2395 (Entrez Gene)
FeMetaboliteCHEBI:18248 (ChEBI)
GLRX5GeneProduct51218 (Entrez Gene)
HSCBGeneProduct150274 (Entrez Gene)
HSPA9GeneProduct3313 (Entrez Gene)
ISCUGeneProduct23479 (Entrez Gene)
L-cysteineMetaboliteCHEBI:17561 (ChEBI)
LYRM4GeneProduct57128 (Entrez Gene)
NARFGeneProduct26502 (Entrez Gene)
NFS1GeneProduct9054 (Entrez Gene)
NFU1GeneProduct27247 (Entrez Gene)
NUBP1GeneProductENSG00000103274 (Ensembl)
NUBP2GeneProduct10101 (Entrez Gene)
SMetaboliteCHEBI:26833 (ChEBI)
[4Fe-4S] clusterMetaboliteCHEBI:49883 (ChEBI)
e-MetaboliteCHEBI:10545 (ChEBI)

Annotated Interactions

No annotated interactions

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