Elabela signaling (Homo sapiens)

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7106121594Promotes growth and pluripotency in human embryonic stem cellsAutophagy, cell survival, proliferation and migration in kidney carcinoma Renca cell Fibrosis markersELA-11Hypoxic/ischemic-induced bone mesenchymal stem cellKidney injury inflammatory responseInflammation and apoptosis in diabetic cardiomyopathy miceI/R-injury induced autophagyKidney injury markersReduces hypertensionrenal injuryInvasion and proliferation in trophoblast cellsIncrease Ca2+ and induce anorexic effect in AVP and CRH neuronsCalcium mobilization in CHO-K1 cellsELA-32Inflammatory markers Apoptosis, fibrosis,mitochondrial dysfunction in cardiomyocyte I/R injury rat modelIntra renal renin-angiotensin systemCardiac disfunction & hypertrophyDiabetic cardiomyopathyNCF2SOD2TNFATG7ATF1 IFNGMMP9CASP3MYH7BAXACTA2BCL2EOMESCCL2IL1BTIMP1EOMESTNFICAM1MAPK1TNFBCL2SIRT3IL6BAXIL1BGATATBXTSIRT3BAXCCL2FSTCOL1A1NLRP3ACE2IL17ANPHS2TNFCOL3A1ROSATRCASP3ICAM1CASP3CYBACOL8ACASP14-HNENPPAMMP9TGFB2LTBP2MCP1BCL2cAMPIL2LCN2BAXSMAD3SYNPOFOSVIMVCAM1RPS6KB1SERPINE1TGFb1BAXMAP1LC3B2IL18TGFB1H2AXBAXACEFOXO3BCL2CYBBFOXM1CASP3PARP1AKT1 RENEIF4EBP1ICAM14-HNETNFRPS6KA6ATG12HAVCR1 CCL2NOS3ATG5COL1A1COL1A1NPPBCYCSPIK3CACHEK1FOXO3IL1BATP6AP2CCL2GDF3MMP2FN1CCND1NCF1MAPK3COL1A1BCL2 FOXM1BCL2IL6HAVCR1CREB1CASP3NLRP3MTORBAXIL1BPOSTNTNFAKT1S1CASP3APJ / APLNRIL6TGFB1CCN2PIK3CAPP129S473T421S236T202PS423S3352310S425S339Y2045S2354, 5P8PY187T1852, 45S424T476MAPK3Y204T202AKT1 PIK3CA12S473Y458Diabetes12cAMPAPJ / APLNRELA-32ELA-32MTOR5APJ / APLNRS335S339ELA-21ELA-32cAMPARRB1S412Y47ARRB2S361T383Y48GNAI2MAPK3T202Y204RPS6KB1T389MTORPAKT1 PMAPK3Y204T202PARP1CASP3ELA-21APJMTOR11AKT1 11PELAAPJMTORAKT1 88PProteinReceptorProteinProteinmRNASmall moleculeLigandInduced activationInhibitionRegulation of gene/protein expressionLeads to through multiple reactionsPTM stateProtein-protein interactionLEGENDPhosphorylationMoleculeGene/ProteinGene/ProteinUpregulationDownregulationMAPK12, 4Y187T185MAPK12, 4T185Y187MAPK1Y1872, 4T185MAPK3Y204T202MAPK1T1856Y187


Description

Schematic representation of ELABELA-mediated signaling

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Bibliography

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  1. ''ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage''; Cardiovasc Res, 2017 PubMed Europe PMC Scholia
  2. Perjés Á, Kilpiö T, Ulvila J, Magga J, Alakoski T, Szabó Z, Vainio L, Halmetoja E, Vuolteenaho O, Petäjä-Repo U, Szokodi I, Kerkelä R; ''Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.''; Basic Res Cardiol, 2016 PubMed Europe PMC Scholia
  3. Wang X, Liang G, Guo Q, Cai W, Zhang X, Ni J, Tao Y, Niu X, Chen S; ''ELABELA improves endothelial cell function via the ELA-APJ axis by activating the PI3K/Akt signalling pathway in HUVECs and EA.hy926 cells.''; Clin Exp Pharmacol Physiol, 2020 PubMed Europe PMC Scholia
  4. Fu J, Chen X, Liu X, Xu D, Yang H, Zeng C, Long H, Zhou C, Wu H, Zheng G, Wang W, Wang T; ''ELABELA ameliorates hypoxic/ischemic-inducedbone mesenchymal stem cell apoptosis via alleviation of mitochondrial dysfunction and activation of PI3K/AKT and ERK1/2 pathways.''; Stem Cell Res Ther, 2020 PubMed Europe PMC Scholia
  5. Ho L, Tan SY, Wee S, Wu Y, Tan SJ, Ramakrishna NB, Chng SC, Nama S, Szczerbinska I, Chan YS, Avery S, Tsuneyoshi N, Ng HH, Gunaratne J, Dunn NR, Reversade B; ''ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.''; Cell Stem Cell, 2015 PubMed Europe PMC Scholia
  6. Zhou L, Sun H, Cheng R, Fan X, Lai S, Deng C; ''ELABELA, as a potential diagnostic biomarker of preeclampsia, regulates abnormally shallow placentation via APJ.''; Am J Physiol Endocrinol Metab, 2019 PubMed Europe PMC Scholia
  7. Yu P, Ma S, Dai X, Cao F; ''Elabela alleviates myocardial ischemia reperfusion-induced apoptosis, fibrosis and mitochondrial dysfunction through PI3K/AKT signaling.''; Am J Transl Res, 2020 PubMed Europe PMC Scholia
  8. ''Reduced ELABELA expression attenuates trophoblast invasion through the PI3K/AKT/mTOR pathway in early onset preeclampsia''; Placenta, 2019 PubMed Europe PMC Scholia
  9. Chen Z, Wu C, Liu Y, Li H, Zhu Y, Huang C, Lin H, Qiao Q, Huang M, Zhu Q, Wang L; ''ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome pathway.''; Cell Death Dis, 2020 PubMed Europe PMC Scholia
  10. Li C, Miao X, Wang S, Liu Y, Sun J, Liu Q, Cai L, Wang Y; ''Elabela may regulate SIRT3-mediated inhibition of oxidative stress through Foxo3a deacetylation preventing diabetic-induced myocardial injury.''; J Cell Mol Med, 2021 PubMed Europe PMC Scholia
  11. Geng Z, Ye C, Tong Y, Zhang F, Zhou YB, Xiong XQ; ''Exacerbated pressor and sympathoexcitatory effects of central Elabela in spontaneously hypertensive rats.''; Am J Physiol Heart Circ Physiol, 2020 PubMed Europe PMC Scholia
  12. Zhang Y, Wang Y, Luo M, Xu F, Lu Y, Zhou X, Cui W, Miao L; ''Elabela protects against podocyte injury in mice with streptozocin-induced diabetes by associating with the PI3K/Akt/mTOR pathway.''; Peptides, 2019 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129693view00:49, 22 May 2024EweitzModified title
126440view18:43, 28 April 2023EgonwFixed references
126439view18:38, 28 April 2023EgonwLicense is CCZero
119768view18:13, 19 August 2021Khanspersconnected interactions
119767view18:11, 19 August 2021KhanspersOntology Term : 'apelin signaling pathway' added !
119766view18:10, 19 August 2021KhanspersOntology Term : 'signaling pathway' added !
119765view18:09, 19 August 2021KhanspersModified title
118894view18:52, 3 June 2021EgonwAlso not Entrez Gene IDs
118796view05:24, 2 June 2021EgonwNot an Entrez Gene identifier
117975view11:04, 23 May 2021EweitzModified title
117083view17:06, 16 May 2021KeshavNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
4-HNEGeneProduct4-HNE
ACE2GeneProductACE2
ACEGeneProductACE
ACTA2GeneProductACTA2
AKT1 Protein207 (Entrez Gene)
AKT1 GeneProductAKT1
AKT1S1Protein84335 (Entrez Gene)
APJ / APLNRGeneProduct
APJGeneProductAPJ
ARRB1GeneProductARRB1
ARRB2GeneProductARRB2
ATF1 GeneProductATF1
ATG12GeneProductATG12
ATG5GeneProductATG5
ATG7GeneProductATG7
ATP6AP2GeneProductATP6AP2
ATRGeneProductATR
BAXGeneProductBAX
BCL2 GeneProductBCL2
BCL2GeneProductBCL2
CASP1GeneProductCASP1
CASP3GeneProductCASP3
CCL2GeneProductCCL2
CCN2GeneProductCCN2
CCND1GeneProductCCND1
CHEK1GeneProductCHEK1
COL1A1GeneProductCOL1A1
COL3A1GeneProductCOL3A1
COL8AGeneProductCOL8A
CREB1GeneProductCREB1
CYBAGeneProductCYBA
CYBBGeneProductCYBB
CYCSGeneProductCYCS
EIF4EBP1GeneProductEIF4EBP1
EOMESGeneProductEOMES
FN1GeneProductFN1
FOSGeneProductFOS
FOXM1GeneProductFOXM1
FOXO3Protein2309 (Entrez Gene)
FOXO3GeneProductFOXO3
FSTGeneProductFST
GATAGeneProductGATA
GDF3GeneProductGDF3
GNAI2GeneProductGNAI2
H2AXGeneProductH2AX
HAVCR1 GeneProductHAVCR1
HAVCR1GeneProductHAVCR1
ICAM1GeneProductICAM1
IFNGGeneProductIFNG
IL17AGeneProductIL17A
IL18GeneProductIL18
IL1BGeneProductIL1B
IL2GeneProductIL2
IL6GeneProductIL6
LCN2GeneProductLCN2
LTBP2GeneProductLTBP2
MAP1LC3B2GeneProductMAP1LC3B2
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK3GeneProductMAPK3
MCP1GeneProductMCP1
MMP2GeneProductMMP2
MMP9GeneProductMMP9
MTORGeneProductMTOR
MYH7GeneProductMYH7
NCF1GeneProductNCF1
NCF2GeneProductNCF2
NLRP3GeneProductNLRP3
NOS3Protein4846 (Entrez Gene)
NPHS2GeneProductNPHS2
NPPAGeneProductNPPA
NPPBGeneProductNPPB
PARP1GeneProductPARP1
PIK3CAGeneProduct5290 (Entrez Gene)
POSTNGeneProductPOSTN
RENGeneProductREN
ROSGeneProductROS
RPS6KA6GeneProductRPS6KA6
RPS6KB1GeneProductRPS6KB1
SERPINE1GeneProductSERPINE1
SIRT3GeneProductSIRT3
SMAD3GeneProductSMAD3
SOD2GeneProductSOD2
SYNPOGeneProductSYNPO
TBXTGeneProductTBXT
TGFB1GeneProductTGFB1
TGFB2GeneProductTGFB2
TGFb1GeneProductTGFb1
TIMP1GeneProductTIMP1
TNFGeneProductTNF
VCAM1GeneProductVCAM1
VIMGeneProductVIM
cAMPGeneProductcAMP

Annotated Interactions

No annotated interactions

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