TAR syndrome (Homo sapiens)

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1, 1913, 1413, 1429-335, 7235, 716, 22251526175, 79926211535, 727, 31-3313, 14241231-3316, 221125206, 18175, 713, 14241185, 72413, 1427, 2810244, 15HydrolysisOn CD8+ T-cellsIn HSCsSubstratesMaintaining normal cholesterol levelsStabilizingNucleoside diphosphate derivativesBidirectional signallingReceptor for collagenCluster proteins, modulate theirtrafficking and activitySensesT-cell exhaustionLys-48 and/or Lys-63 linkedDuring bacterial infectionDNAFormation of proapoptotic isoformsIn response to sensing of non-self RNAPersistentRNA polymeraseDuring viral infectionNF-κBOn NK cellsMulti drug resistanceEJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAIn activated T-cellsIn activated NK cellsE2 dependentchr1:145,394,955Splicing modulationRequired for pre-mRNA as component of the splicosomeNK cell cytotoxic activityIn immune privileged sitesOn activated CD4+ T-cellsTraps EJC onto spliced mRNAAntigenProgressivelyMost probably non-functionalVoltage dependent anion channel required foracidification and functions of the Golgi apparatusthat may function in counter-ion conductance Receptor for classical andnon-classical MHCI moleculesIn the brush border of the proximal tubule of the kidneyCostimulatory signals toactivated/memory CD8+ T-cellsType I IFNsMembrane protrusion and elongationon the peroxisomal surfaceAngiogenesisTCR signallingPeroxisomal proliferationLIX1LPOLR3GPDZK1SubstratemTORC1POLR3GLLymphocyte developmentMaturation of NK cellsHFE2SIRT1HepcidinNonsense mediated decay pathwayViral peptideRNF115Steroid hormone signalling pathwayEIF4A3non-self dsDNAPEX11BPOLR3CNUDT17CXCR4RIG-I pathwayHLA-CDNM1LLCKnon-self RNACDKN1BTXNSTAT3HLA-AIFNGANKRD34ASUMO1TXNIPCollagenRBM8ATNFRSF14Peroxisome divisionDNAZFHX3METABCC2CCAR2POLR3FPI3KPDZK1IP1DNAMAGOHGnRH-IIProduction of anti-microbial proteinsand inflammatory cytokinesTBPITGA10CD3RABL3PYM1STAT pathwayCOPS5PDZK1PIAS3MTA1Signalling pathwaysSLC26A6CD247CFTRANKRD35BCL2L13BMPGNRHR2CD28 costimulatory signalingIron homeostasisUBE2IRNAGPR89AFLT3Proteasomal degradation of DDIT4CD160SCARB1RNABRF1NHERF1Tumour cell growthHLA-GPOLR3CEGFRRBM8AMTA1SCCAR2SZFHX3SubstrateUCXCR4METFLT3EGFRUUUUSignalling pathwaysDuring viral infectionHLA-AIn immune privileged sites


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Bibliography

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History

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CompareRevisionActionTimeUserComment
134655view09:21, 24 July 2024EgonwCompleted a datasource
134452view00:02, 22 July 2024EweitzOntology Term : 'disease of mental health' added !
127046view09:38, 26 July 2023FehrhartOntology Term : 'Disease' added !
127045view09:38, 26 July 2023FehrhartOntology Term : 'disease pathway' added !
127044view09:37, 26 July 2023FehrhartModified description
127043view09:30, 26 July 2023Fehrhartcorrections and updates (done)
127042view07:47, 26 July 2023Fehrhartupdate in progress
127041view06:54, 26 July 2023Fehrhartupdate in progress
127029view13:11, 24 July 2023Fehrhartupdate
127028view12:36, 24 July 2023Fehrhartupgrade
127027view12:00, 24 July 2023Fehrhartupgrade
126901view14:14, 30 June 2023JmillanacostaChanged legend interactions and nodes to graphical objects
126849view09:37, 27 June 2023Ewoud
126578view15:20, 4 June 2023Ewoudfiller
126517view15:21, 23 May 2023EwoudNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCC2GeneProductENSG00000023839 (Ensembl)
ANKRD34AGeneProductENSG00000181039
ANKRD35GeneProductENSG00000198483
BCL2L13GeneProductENSG00000099968 (Ensembl)
BMPMetaboliteCHEBI:60815 (ChEBI)
BRF1GeneProductENSG00000185024 (Ensembl)
CCAR2GeneProductENSG00000158941 (Ensembl)
CD160GeneProductENSG00000117281
CD247GeneProductENSG00000198821 (Ensembl)
CD28 costimulatory signalingPathway
CD3GeneProductENSG00000167286 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CFTRGeneProductENSG00000001626 (Ensembl)
COPS5GeneProductENSG00000121022 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
CollagenMetaboliteCHEBI:3815 (ChEBI)
DNAGeneProduct
DNM1LGeneProductENSG00000087470 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4A3GeneProductENSG00000141543 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
GNRHR2GeneProductENSG00000211451
GPR89AGeneProductENSG00000117262
GnRH-IIMetaboliteCHEBI:80298 (ChEBI)
HFE2GeneProductENSG00000168509
HLA-AGeneProductENSG00000206503 (Ensembl)
HLA-CGeneProductENSG00000204525 (Ensembl)
HLA-GGeneProductENSG00000204632 (Ensembl)
HepcidinMetaboliteHMDB0259694 (HMDB)
IFNGGeneProductENSG00000111537 (Ensembl)
ITGA10GeneProductENSG00000143127
Iron homeostasisPathway
LCKGeneProductENSG00000182866 (Ensembl)
LIX1LGeneProductENSG00000152022
Lymphocyte developmentPathway
MAGOHGeneProductENSG00000162385 (Ensembl)
METGeneProductENSG00000105976 (Ensembl)
MTA1GeneProductENSG00000182979 (Ensembl)
Maturation of NK cellsPathway
NHERF1GeneProductENSG00000109062 (Ensembl)
NUDT17GeneProductENSG00000186364
Nonsense mediated decay pathwayPathway
PDZK1GeneProductENSG00000174827
PDZK1GeneProductENSG00000174827 (Ensembl)
PDZK1IP1GeneProductENSG00000162366 (Ensembl)
PEX11BGeneProductENSG00000131779
PI3KMetaboliteCHEBI:89296 (ChEBI)
PIAS3GeneProductENSG00000131788
POLR3CGeneProductENSG00000186141
POLR3CGeneProductENSG00000186141 (Ensembl)
POLR3FGeneProductENSG00000132664 (Ensembl)
POLR3GGeneProductENSG00000113356 (Ensembl)
POLR3GLGeneProductENSG00000121851
PYM1GeneProductENSG00000170473 (Ensembl)
Peroxisomal proliferationPathway
Peroxisome divisionPathway
Production of anti-microbial proteins and inflammatory cytokinesPathway
Proteasomal degradation of DDIT4Pathway
RABL3GeneProductENSG00000144840 (Ensembl)
RBM8AGeneProductENSG00000131795
RIG-I pathwayPathway
RNARna
RNF115GeneProductENSG00000121848
SCARB1GeneProductENSG00000073060 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SLC26A6GeneProductENSG00000225697 (Ensembl)
STAT pathwayPathway
STAT3GeneProductENSG00000168610 (Ensembl)
SUMO1GeneProductENSG00000116030 (Ensembl)
Signalling pathwaysPathway
Steroid hormone signalling pathwayPathway
SubstrateMetabolite
TBPMetaboliteCHEBI:35019 (ChEBI)
TCR signallingPathway
TNFRSF14GeneProductENSG00000157873 (Ensembl)
TXNGeneProductENSG00000136810 (Ensembl)
TXNIPGeneProductENSG00000117289
Tumour cell growthPathway
UBE2IGeneProductENSG00000103275 (Ensembl)
Viral peptideMetabolite
ZFHX3GeneProductENSG00000140836 (Ensembl)
mTORC1ProteinF5H479 (Uniprot-TrEMBL)
non-self RNARna
non-self dsDNAGeneProduct

Annotated Interactions

No annotated interactions

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