Androgen biosynthesis (Homo sapiens)
From WikiPathways
Description
Androgen metabolism from L Schiffer
Quality Tags
Ontology Terms
Pathway Ontology : lipid metabolic pathway steroid biosynthetic pathway
Bibliography
- Storbeck KH, Bloem LM, Africander D, Schloms L, Swart P, Swart AC; ''11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer?''; Mol Cell Endocrinol, 2013 PubMed Europe PMC Scholia
- Barnard L, Nikolaou N, Louw C, Schiffer L, Gibson H, Gilligan LC, Gangitano E, Snoep J, Arlt W, Tomlinson JW, Storbeck KH; ''The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1.''; J Steroid Biochem Mol Biol, 2020 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
16alpha-hydroxyandrosterone | Metabolite | LMST02020133 (LIPID MAPS) | |
11-Keto-5beta-dihydrotestosterone | Metabolite | LMST02020127 (LIPID MAPS) | |
11-Ketoandrosterone | Metabolite | LMST02020087 (LIPID MAPS) | |
11-Ketodihydrotestosterone | Metabolite | LMST02020122 (LIPID MAPS) | |
11-Ketoetiocholanolone | Metabolite | LMST02020123 (LIPID MAPS) | |
11-keto-testosterone | Metabolite | LMST02020120 (LIPID MAPS) | |
11beta-Hydroxyandrostenedione | Metabolite | LMST02020066 (LIPID MAPS) | |
11beta-hydroxy testosterone | Metabolite | LMST02020124 (LIPID MAPS) | |
11beta-hydroxyandrostan-3,17-dione | Metabolite | LMST02020121 (LIPID MAPS) | |
11beta-hydroxyandrosterone | Metabolite | LMST02020086 (LIPID MAPS) | |
16alpha- hydroxyprogesterone | Metabolite | LMST02030182 (LIPID MAPS) | |
16alpha-Hydroxydehydroepiandrosterone | Metabolite | LMST02020064 (LIPID MAPS) | |
16alpha-Hydroxyetiocholanolone | Metabolite | LMST02020132 (LIPID MAPS) | |
16alpha-Hydroxytestosterone | Metabolite | LMST02020125 (LIPID MAPS) | |
16alpha-hydroxy androst-4-ene-3,17-dione | Metabolite | ||
16alpha-hydroxyestrone | Metabolite | LMST02010041 (LIPID MAPS) | |
17alpha- hydroxypregnenolone | Metabolite | LMST02030089 (LIPID MAPS) | |
17alpha- hydroxyprogesterone | Metabolite | LMST02030161 (LIPID MAPS) | |
17alpha-hydroxy- alloprogesterone | Metabolite | LMST02030305 (LIPID MAPS) | |
3beta,16alpha-Dihydroxy- androstenone sulfate | Metabolite | LMST05020022 (LIPID MAPS) | |
5-Androstenediol | Metabolite | LMST02020005 (LIPID MAPS) | |
5alpha- androstanedione | Metabolite | LMST02020085 (LIPID MAPS) | |
5alpha- dihydrotesosterone | Metabolite | LMST02020042 (LIPID MAPS) | |
5alpha-Androstan- 3alpha,16alpha,17beta-triol | Metabolite | LMST02020134 (LIPID MAPS) | |
5alpha-Androstan- 3alpha,17beta-diol-11-one | Metabolite | LMST02020129 (LIPID MAPS) | |
5alpha-Androstane-3,11,17-trione | Metabolite | LMST02020130 (LIPID MAPS) | |
5alpha-Pregnan-17alpha-ol-3,20-dione | Metabolite | LMST02030304 (LIPID MAPS) | |
5alpha-androstan- 11beta,17beta-diol-3one | Metabolite | LMST02020136 (LIPID MAPS) | |
5alpha-androstan- 16alpha,17beta-diol-3one | Metabolite | LMST02020138 (LIPID MAPS) | |
5alpha-androstan- 16alpha-ol-3,17-dione | Metabolite | LMST02020141 (LIPID MAPS) | |
5alpha-androstane- 3alpha,17beta-diol | Metabolite | LMST02020052 (LIPID MAPS) | |
5alpha-dihydroprogesterone | Metabolite | LMST02030170 (LIPID MAPS) | |
5beta- Dihydrotestosterone | Metabolite | LMST02020069 (LIPID MAPS) | |
5beta- androstanedione | Metabolite | LMST02020058 (LIPID MAPS) | |
5beta-Androstan- 3alpha,16alpha,17beta-triol | Metabolite | LMST02020135 (LIPID MAPS) | |
5beta-Androstan- 3alpha,17beta-diol-11-one | Metabolite | LMST02020128 (LIPID MAPS) | |
5beta-Androstane-3,11,17-trione | Metabolite | LMST02020131 (LIPID MAPS) | |
5beta-androstan- 16alpha,17beta-diol-3one | Metabolite | LMST02020139 (LIPID MAPS) | |
5beta-androstan- 16alpha-ol-3,17-dione | Metabolite | LMST02020140 (LIPID MAPS) | |
5beta-androstane- 3alpha,17beta-diol | Metabolite | LMST02020077 (LIPID MAPS) | |
6beta-hydroxytestosterone | Metabolite | LMST02020054 (LIPID MAPS) | |
AKR1C1 | GeneProduct | Q04828 (Uniprot-TrEMBL) | |
AKR1C2 | GeneProduct | P52895 (Uniprot-TrEMBL) | |
AKR1C3 | GeneProduct | P42330 (Uniprot-TrEMBL) | |
AKR1C4 | GeneProduct | P17516 (Uniprot-TrEMBL) | |
AKR1D1 | GeneProduct | P51857 (Uniprot-TrEMBL) | |
Adrenosterone | Metabolite | LMST02020126 (LIPID MAPS) | |
Allopregnanolone | Metabolite | LMST02030130 (LIPID MAPS) | |
Androstenedione | Metabolite | LMST02020007 (LIPID MAPS) | |
Androsterone | Metabolite | LMST02020001 (LIPID MAPS) | |
CYP11B1 | GeneProduct | P15538 (Uniprot-TrEMBL) | |
CYP17A1 | GeneProduct | P05093 (Uniprot-TrEMBL) | |
CYP3A4 | GeneProduct | P08684 (Uniprot-TrEMBL) | |
CYP3A7 | GeneProduct | P24462 (Uniprot-TrEMBL) | |
DHEAS | Metabolite | LMST05020010 (LIPID MAPS) | |
Dehydroepiandrosterone | Metabolite | LMST02020021 (LIPID MAPS) | |
Estriol | Metabolite | LMST02010003 (LIPID MAPS) | |
Etiocholanolone | Metabolite | LMST02020059 (LIPID MAPS) | |
HSD11B1 | GeneProduct | P28845 (Uniprot-TrEMBL) | |
HSD11B2 | GeneProduct | P80365 (Uniprot-TrEMBL) | |
HSD17B1 | GeneProduct | P14061 (Uniprot-TrEMBL) | |
HSD17B2 | GeneProduct | P37059 (Uniprot-TrEMBL) | |
HSD17B3 | GeneProduct | P37058 (Uniprot-TrEMBL) | |
HSD17B4 | GeneProduct | P51659 (Uniprot-TrEMBL) | |
HSD3B1 | GeneProduct | P14060 (Uniprot-TrEMBL) | |
HSD3B2 | GeneProduct | P26439 (Uniprot-SwissProt) | |
Other | GeneProduct | ||
POR | GeneProduct | P16435 (Uniprot-TrEMBL) | |
Pregnenolone | Metabolite | LMST02030088 (LIPID MAPS) | |
Progesterone | Metabolite | LMST02030159 (LIPID MAPS) | |
SRD5A1 | GeneProduct | P18405 (Uniprot-TrEMBL) | |
SRD5A2 | GeneProduct | P31213 (Uniprot-TrEMBL) | |
STS | GeneProduct | P08842 (Uniprot-TrEMBL) | |
SULT2A1 | GeneProduct | Q06520 (Uniprot-TrEMBL) | |
Testosterone | Metabolite | LMST02020002 (LIPID MAPS) |
Annotated Interactions
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Source | Target | Type | Database reference | Comment |
---|---|---|---|---|
11beta-Hydroxyandrostenedione | Adrenosterone | mim-conversion | 69409 (Rhea) | |
Adrenosterone | 11-keto-testosterone | mim-conversion | 53485 (Rhea) | |
Androstenedione | 5alpha- androstanedione | mim-conversion | 50817 (Rhea) | EC:1.3.1.22 |
Androstenedione | 5beta- androstanedione | mim-conversion | 46657 (Rhea) | EC:1.3.1.3 |
Androstenedione | Testosterone | mim-conversion | 14931 (Rhea) | EC:1.1.1.239 |
DHEAS | 3beta,16alpha-Dihydroxy- androstenone sulfate | mim-conversion | 47225 (Rhea) | |
DHEAS | Dehydroepiandrosterone | mim-conversion | 19874 (Rhea) | EC:3.1.6.2 |
Dehydroepiandrosterone | 16alpha-Hydroxydehydroepiandrosterone | mim-conversion | 47221 (Rhea) | |
Dehydroepiandrosterone | 5-Androstenediol | mim-conversion | 46629 (Rhea) | |
Dehydroepiandrosterone | DHEAS | mim-conversion | 51217 (Rhea) | EC:2.8.2.2 |
Pregnenolone | 17alpha- hydroxypregnenolone | mim-conversion | 50237 (Rhea) | EC:1.14.14.19 |
Progesterone | 17alpha- hydroxyprogesterone | mim-conversion | 46309 (Rhea) | EC:1.14.14.19 |
Progesterone | 5alpha-dihydroprogesterone | mim-conversion | 21954 (Rhea) | EC:1.3.1.22 |
Testosterone | 11beta-hydroxy testosterone | mim-conversion | 53445 (Rhea) | EC:1.14.15.4 |
Testosterone | 5alpha- dihydrotesosterone | mim-conversion | 50822 (Rhea) | EC:1.3.1.22 |
Testosterone | 6beta-hydroxytestosterone | mim-conversion | 46297 (Rhea) | EC:1.14.14.1 |
Testosterone | Androstenedione | mim-conversion | 14930 (Rhea) | EC:1.1.1.51 |