TAR syndrome (Homo sapiens)

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561216, 18, 2228, 294, 332684, 339, 319, 314, 3327, 35307241112153, 2532109, 31779, 3113, 16, 18, 22, 342179, 3116, 18, 22, 2862627, 355, 2624, 331411723119, 209, 314, 332Receptor for collagenCluster proteins, modulate theirtrafficking and activityEJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAStabilizingMulti drug resistanceRequired for pre-mRNA as component of the splicosomeDuring viral infectionMost probably non-functionalIn response to sensing of non-self RNAMembrane protrusion and elongationon the peroxisomal surfaceOn NK cellsType I IFNsT-cell exhaustionMaturation of NK cellsNucleoside diphosphate derivativesIn the brush border of the proximal tubule of the kidneyDuring bacterial infectionVoltage dependent anion channel required foracidification and functions of the Golgi apparatusthat may function in counter-ion conductance In HSCschr1:145,394,955SubstratesCostimulatory signals toactivated/memory CD8+ T-cellsDNASplicing modulationIn immune privileged sitesProgressivelyMaintaining normal cholesterol levelsTumour cell growthNF-κBFunction unknownLys-48 and/or Lys-63 linkedAntigenBidirectional signallingIn activated NK cellsReceptor for classical andnon-classical MHCI moleculesIn activated T-cellsOn activated CD4+ T-cellsAngiogenesisPersistentNK cell cytotoxic activityOn CD8+ T-cellsTraps EJC onto spliced mRNASensesFormation of proapoptotic isoformsHydrolysisE2 dependentGnRH-IIHJVCFTRMTA1TBPTCR signallingLIX1LHLA-CDDIT4SUMO1CD28 costimulatory signalingBCL2L13EIF4A3SubstrateRBM8AFLT3SCARB1POLR3GLANKRD34ARNF115POLR3FSIRT1IFNGPeroxisomal proliferationJAK/STAT pathwayANKRD35GPR89ALymphocyte developmentDNA-directed RNA polymerase III complex, POLR3GL variantPDZK1CCAR2PEX11BSLC26A6UBE2INUDT17DNAHAMPnon-self dsDNAHLA-ASignalling pathwaysnon-self RNAPI3KPDZK1mTORC1LCKNonsense mediated decay pathwayRABL3CD160CD247EGFRPOLR3CGNRHR2NHERF1STAT3PIAS3Viral peptideCell cycleTNFRSF14ITGA10HLA-GCXCR4RIG-I pathwayPOLR3CPOLR3GBMPPYM1DNM1LCD3Iron uptake and transportMAGOHTXNBRF1RNAPDZK1IP1METTXNIPPeroxisome divisionProduction of anti-microbial proteinsand inflammatory cytokinesSteroid hormone signalling pathwayCollagenFURINZFHX3ABCC2RBM8AMTA1SCCAR2SZFHX3SubstrateUCXCR4METFLT3EGFRUUUUSignalling pathwaysDuring viral infectionHLA-AIn immune privileged sitesFunction unknownCatalysisBindingUbiquitinatedLEGENDInhibitionSumoylatedConversionStimulationUSLIX1L


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Bibliography

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History

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CompareRevisionActionTimeUserComment
134655view09:21, 24 July 2024EgonwCompleted a datasource
134452view00:02, 22 July 2024EweitzOntology Term : 'disease of mental health' added !
127046view09:38, 26 July 2023FehrhartOntology Term : 'Disease' added !
127045view09:38, 26 July 2023FehrhartOntology Term : 'disease pathway' added !
127044view09:37, 26 July 2023FehrhartModified description
127043view09:30, 26 July 2023Fehrhartcorrections and updates (done)
127042view07:47, 26 July 2023Fehrhartupdate in progress
127041view06:54, 26 July 2023Fehrhartupdate in progress
127029view13:11, 24 July 2023Fehrhartupdate
127028view12:36, 24 July 2023Fehrhartupgrade
127027view12:00, 24 July 2023Fehrhartupgrade
126901view14:14, 30 June 2023JmillanacostaChanged legend interactions and nodes to graphical objects
126849view09:37, 27 June 2023Ewoud
126578view15:20, 4 June 2023Ewoudfiller
126517view15:21, 23 May 2023EwoudNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCC2GeneProductENSG00000023839 (Ensembl)
ANKRD34AGeneProductENSG00000181039 (Ensembl)
ANKRD35GeneProductENSG00000198483 (Ensembl)
BCL2L13GeneProductENSG00000099968 (Ensembl)
BMPMetaboliteCHEBI:60815 (ChEBI)
BRF1GeneProductENSG00000185024 (Ensembl)
CCAR2GeneProductENSG00000158941 (Ensembl)
CD160GeneProductENSG00000117281 (Ensembl)
CD247GeneProductENSG00000198821 (Ensembl)
CD28 costimulatory signalingPathway
CD3GeneProductENSG00000167286 (Ensembl)
CFTRGeneProductENSG00000001626 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
Cell cyclePathwayWP179 (WikiPathways)
CollagenMetaboliteCHEBI:3815 (ChEBI)
DDIT4GeneProductENSG00000168209 (Ensembl)
DNAGeneProduct
DNA-directed RNA polymerase III complex, POLR3GL variantComplexCPX-7482
DNM1LGeneProductENSG00000087470 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4A3GeneProductENSG00000141543 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
FURINGeneProductENSG00000140564 (Ensembl)
GNRHR2GeneProductENSG00000211451 (Ensembl)
GPR89AGeneProductENSG00000117262 (Ensembl)
GnRH-IIMetaboliteCHEBI:80298 (ChEBI)
HAMPGeneProductENSG00000105697 (Ensembl) Hepcidin
HJVGeneProductENSG00000168509 (Ensembl) HAEMOJUVELIN, HEMOJUVELIN, HFE2, HFE2A
HLA-AGeneProductENSG00000206503 (Ensembl)
HLA-CGeneProductENSG00000204525 (Ensembl)
HLA-GGeneProductENSG00000204632 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
ITGA10GeneProductENSG00000143127 (Ensembl)
Iron uptake and transportPathwayWP2670 (WikiPathways)
JAK/STAT pathwayPathwaymap04630 (KEGG Pathway)
LCKGeneProductENSG00000182866 (Ensembl)
LIX1LGeneProductENSG00000152022 (Ensembl)
Lymphocyte developmentPathway
MAGOHGeneProductENSG00000162385 (Ensembl)
METGeneProductENSG00000105976 (Ensembl)
MTA1GeneProductENSG00000182979 (Ensembl)
NHERF1GeneProductENSG00000109062 (Ensembl)
NUDT17GeneProductENSG00000186364 (Ensembl)
Nonsense mediated decay pathwayPathway
PDZK1GeneProductENSG00000174827 (Ensembl)
PDZK1IP1GeneProductENSG00000162366 (Ensembl)
PEX11BGeneProductENSG00000131779 (Ensembl)
PI3KMetaboliteCHEBI:89296 (ChEBI)
PIAS3GeneProductENSG00000131788 (Ensembl)
POLR3CGeneProductENSG00000186141 (Ensembl)
POLR3FGeneProductENSG00000132664 (Ensembl)
POLR3GGeneProductENSG00000113356 (Ensembl)
POLR3GLGeneProductENSG00000121851 (Ensembl)
PYM1GeneProductENSG00000170473 (Ensembl)
Peroxisomal proliferationPathway
Peroxisome divisionPathway
Production of anti-microbial proteins and inflammatory cytokinesPathway
RABL3GeneProductENSG00000144840 (Ensembl)
RBM8AGeneProductENSG00000131795 (Ensembl)
RIG-I pathwayPathway
RNARna
RNF115GeneProductENSG00000121848 (Ensembl)
SCARB1GeneProductENSG00000073060 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SLC26A6GeneProductENSG00000225697 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
SUMO1GeneProductENSG00000116030 (Ensembl)
Signalling pathwaysPathway
Steroid hormone signalling pathwayPathway
SubstrateMetabolite
TBPMetaboliteCHEBI:35019 (ChEBI)
TCR signallingPathway
TNFRSF14GeneProductENSG00000157873 (Ensembl)
TXNGeneProductENSG00000136810 (Ensembl)
TXNIPGeneProductENSG00000117289 (Ensembl)
UBE2IGeneProductENSG00000103275 (Ensembl)
Viral peptideMetabolite
ZFHX3GeneProductENSG00000140836 (Ensembl)
mTORC1ProteinF5H479 (Uniprot-TrEMBL)
non-self RNARna
non-self dsDNAGeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5362"
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