TAR syndrome (Homo sapiens)

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3612, 203112, 2011, 349, 252812, 2011, 3437342737, 302818292214361, 8, 10, 133837321, 4, 10, 13, 162611, 3417, 23323612, 202112, 205217, 231, 10, 1337611, 3414, 3212, 20378, 1511, 34353824, 332221T-cell exhaustionPeroxisome proliferation/divisionE2 dependentStabilizingCostimulatory signals toactivated/memory CD8+ T-cellsPersistentIn activated T-cellsLys-48 and/or Lys-63 linkedBidirectional signallingCluster proteins, modulate theirtrafficking and activityMaturation of NK cellsMulti drug resistanceFunction unknownNK cell cytotoxic activitySplicing modulationType I IFNsOn NK cellsAntigenIn the brush border of the proximal tubule of the kidneyFormation of proapoptotic isoformsIn immune privileged sitesTumour cell growthNucleoside diphosphate derivativesDuring viral infectionReceptor for classical andnon-classical MHCI moleculesVoltage dependent anion channel required foracidification and functions of the Golgi apparatusthat may function in counter-ion conductance In activated NK cellsRequired for pre-mRNA as component of the splicosomeprobably non-functionalpseudogeneIn response to sensing of non-self RNADuring bacterial infectionMaintaining normal cholesterol levelsExon junction complex disassembly in the cytoplasm and translation enhancement of exon junction complex bearing spliced mRNAHydrolysisNF-κBchr1:145,394,955Steroid hormone signallingOn activated CD4+ T-cellsAngiogenesisIn HSCsTraps exon junction complexonto spliced mRNASensesProgressivelyOn CD8+ T-cellsRBCK1SUMO2EIF4A3TXNLCKSIRT1STAT3ANKRD35Iron uptake and transportZFHX3POLR3FDDIT4SubstratePEX11BFURINTBPCollagenDNARIG-I pathwayHDAC2PDZK1IP1MITD1HLA-CITGB1DNM1CCAR2PDZK1FLT3RBM8ACXCR4TNFRSF14POLR3GGPR89APYM1POLR3GLCell cycleRNAnon-self dsDNACD247UBE2ITXNIPCD160MTA1MAGOHSignalling pathwaysPDZK1EGFRITGA10GNRHR2CD3ANKRD34ADNABRF1PEX19SCARB1Viral peptideLymphocyte developmentMETNHERF1CFTRIFNGHLA-GDNA-directed RNA polymerase III complex, POLR3GL variantSLC26A6non-self RNAPOLR3CRNF115Production of anti-microbial proteinsand inflammatory cytokinesCD28 costimulatory signalingJAK/STAT pathwayBCL2L13mTORC1PIAS3NUDT17PI3KABCC2Nonsense-Mediated DecayBMPHLA-ARABL3TCR signallingHAMPHJVPOLR3CLIX1LRBM8AMTA1SCCAR2SZFHX3SubstrateUCXCR4METFLT3EGFRUUUUSignalling pathwaysDuring viral infectionHLA-AIn immune privileged sitesCatalysisBindingUbiquitinatedLEGENDInhibitionSumoylatedConversionStimulationUSLIX1LS


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Bibliography

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History

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CompareRevisionActionTimeUserComment
134655view09:21, 24 July 2024EgonwCompleted a datasource
134452view00:02, 22 July 2024EweitzOntology Term : 'disease of mental health' added !
127046view09:38, 26 July 2023FehrhartOntology Term : 'Disease' added !
127045view09:38, 26 July 2023FehrhartOntology Term : 'disease pathway' added !
127044view09:37, 26 July 2023FehrhartModified description
127043view09:30, 26 July 2023Fehrhartcorrections and updates (done)
127042view07:47, 26 July 2023Fehrhartupdate in progress
127041view06:54, 26 July 2023Fehrhartupdate in progress
127029view13:11, 24 July 2023Fehrhartupdate
127028view12:36, 24 July 2023Fehrhartupgrade
127027view12:00, 24 July 2023Fehrhartupgrade
126901view14:14, 30 June 2023JmillanacostaChanged legend interactions and nodes to graphical objects
126849view09:37, 27 June 2023Ewoud
126578view15:20, 4 June 2023Ewoudfiller
126517view15:21, 23 May 2023EwoudNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCC2GeneProductENSG00000023839 (Ensembl)
ANKRD34AGeneProductENSG00000181039 (Ensembl)
ANKRD35GeneProductENSG00000198483 (Ensembl)
BCL2L13GeneProductENSG00000099968 (Ensembl)
BMPMetaboliteCHEBI:60815 (ChEBI)
BRF1GeneProductENSG00000185024 (Ensembl)
CCAR2GeneProductENSG00000158941 (Ensembl)
CD160GeneProductENSG00000117281 (Ensembl)
CD247GeneProductENSG00000198821 (Ensembl)
CD28 costimulatory signalingPathway
CD3GeneProductENSG00000167286 (Ensembl)
CFTRGeneProductENSG00000001626 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
Cell cyclePathwayWP179 (WikiPathways)
CollagenMetaboliteCHEBI:3815 (ChEBI)
DDIT4GeneProductENSG00000168209 (Ensembl)
DNAGeneProduct
DNA-directed RNA polymerase III complex, POLR3GL variantComplexCPX-7482
DNAMetaboliteCHEBI:16991 (ChEBI)
DNM1GeneProductENSG00000106976 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4A3GeneProductENSG00000141543 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
FURINGeneProductENSG00000140564 (Ensembl)
GNRHR2GeneProductENSG00000211451 (Ensembl)
GPR89AGeneProductENSG00000117262 (Ensembl)
HAMPGeneProductENSG00000105697 (Ensembl) Hepcidin
HDAC2GeneProductENSG00000196591 (Ensembl)
HJVGeneProductENSG00000168509 (Ensembl) HAEMOJUVELIN, HEMOJUVELIN, HFE2, HFE2A
HLA-AGeneProductENSG00000206503 (Ensembl)
HLA-CGeneProductENSG00000204525 (Ensembl)
HLA-GGeneProductENSG00000204632 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
ITGA10GeneProductENSG00000143127 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
Iron uptake and transportPathwayWP2670 (WikiPathways)
JAK/STAT pathwayPathwaymap04630 (KEGG Pathway)
LCKGeneProductENSG00000182866 (Ensembl)
LIX1LGeneProductENSG00000152022 (Ensembl)
Lymphocyte developmentPathway
MAGOHGeneProductENSG00000162385 (Ensembl)
METGeneProductENSG00000105976 (Ensembl)
MITD1GeneProductENSG00000158411 (Ensembl)
MTA1GeneProductENSG00000182979 (Ensembl)
NHERF1GeneProductENSG00000109062 (Ensembl)
NUDT17GeneProductENSG00000186364 (Ensembl)
Nonsense-Mediated DecayPathwayWP2710 (WikiPathways)
PDZK1GeneProductENSG00000174827 (Ensembl)
PDZK1IP1GeneProductENSG00000162366 (Ensembl)
PEX11BGeneProductENSG00000131779 (Ensembl)
PEX19GeneProductENSG00000162735 (Ensembl)
PI3KMetaboliteCHEBI:89296 (ChEBI)
PIAS3GeneProductENSG00000131788 (Ensembl)
POLR3CGeneProductENSG00000186141 (Ensembl)
POLR3FGeneProductENSG00000132664 (Ensembl)
POLR3GGeneProductENSG00000113356 (Ensembl)
POLR3GLGeneProductENSG00000121851 (Ensembl)
PYM1GeneProductENSG00000170473 (Ensembl)
Production of anti-microbial proteins and inflammatory cytokinesPathway
RABL3GeneProductENSG00000144840 (Ensembl)
RBCK1GeneProductENSG00000125826 (Ensembl)
RBM8AGeneProductENSG00000131795 (Ensembl)
RIG-I pathwayPathway
RNARna
RNF115GeneProductENSG00000121848 (Ensembl)
SCARB1GeneProductENSG00000073060 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SLC26A6GeneProductENSG00000225697 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
SUMO2GeneProductENSG00000188612 (Ensembl)
Signalling pathwaysPathway
SubstrateMetabolite
TBPMetaboliteCHEBI:35019 (ChEBI)
TCR signallingPathway
TNFRSF14GeneProductENSG00000157873 (Ensembl)
TXNGeneProductENSG00000136810 (Ensembl)
TXNIPGeneProductENSG00000117289 (Ensembl)
UBE2IGeneProductENSG00000103275 (Ensembl)
Viral peptideMetabolite
ZFHX3GeneProductENSG00000140836 (Ensembl)
mTORC1ProteinF5H479 (Uniprot-TrEMBL)
non-self RNARna
non-self dsDNAGeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5362"
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