Hippo signaling regulation (Homo sapiens)

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1CadherinRho GTPasesGNAQPRKCHPRKAA2PRKCAPRKAB2PRKCGCDH13PRKAG2CDH19PRKAG3SMAD3CDH16CDH12PRKCDPRKCICDH20PRKAG1PRKD3CDH8PRKAA1PRKACACDH3CDH22CDH10G Protein SignalingCDH6CDH9CDH15PRKCEGNASPRKCZCDH11CDH17GNAI3PRKAR1BPLCB2CDH24PRKACGPRKCQCDH4Mevalonate PathwayCDH1GNALGNA11PRKAR1APRKAR2AGNAI2PRKCBCDH2PRKAR2BCDH7PLCB1Energy StressCDC42PRKACBPRKAB1CDH18SMAD2PLCB4CDH5MTORPLCB3NucleusLATS2STK3PLATS1PNF2PSTK4PTEAD1TEAD2TEAD3TEAD4AMPKTGF-Beta SignalingFGFR2KDRINSRFGFR3IGF1RKITFGFR1EPHA2EGFRCSF1RFGFR4FLT1FLT4NGFRMETPDGFRAPDGFRBTEKRTKFLT3NTRK1NTRK2PI3K/AKT SignalingRHOARAC1F-ActinWNT SignalingLEF1TCF7L1TCF7L2TCF7CTNNB1WWTR1PYAP1PPPWWTR1YAP1PPPP


Description

Hippo signaling and the activation of YAP1/TAZ transcription is regulated by many other pathways (green labels) and factors. For example, the activation of SMAD and Beta catenin/TCF/LEF via TGF-beta signaling and WNT signaling pathways, respectively, enhanced the transcription of YAP1/TAZ target genes. This enhanced activity induces more aggressive phenotypes of malignant mesothelioma cells such as cell proliferation, invasion, and epithelial–mesenchymal transition (EMT). This pathway was created based on figure 2 from Sekido et al. Phosphorylation sites were added based on information from PhosphoSitePlus, www.phosphosite.org.

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Ontology Terms

 

Bibliography

  1. Sekido Y; ''Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma.''; Cancers (Basel), 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129833view00:23, 23 May 2024EweitzModified title
128050view11:14, 23 January 2024EweitzStandardize case
127211view19:24, 17 August 2023Khanspersupdate board height
127210view19:22, 17 August 2023Khanspersremove extra nodes, update description
127209view19:16, 17 August 2023Khanspersupdated YAP/TAZ and added phosphosites
120395view08:52, 30 November 2021Fehrhartboxed pathway nodes
117169view09:53, 18 May 2021EweitzModified title
103347view22:50, 22 February 2019AlexanderPicoupdated mim-inhibitions
103314view00:29, 22 February 2019AlexanderPicoOntology Term : 'disease pathway' added !
103313view00:29, 22 February 2019AlexanderPicoOntology Term : 'signaling pathway' added !
103312view00:29, 22 February 2019AlexanderPicoOntology Term : 'Hippo signaling pathway' added !
103311view00:29, 22 February 2019AlexanderPicoOntology Term : 'malignant mesothelioma' added !
103310view00:28, 22 February 2019AlexanderPicoModified description
103309view00:22, 22 February 2019AlexanderPicoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CDC42GeneProduct998 (Entrez Gene)
CDH10GeneProduct1008 (Entrez Gene) Cadherin
CDH11GeneProduct1009 (Entrez Gene) Cadherin
CDH12GeneProduct1010 (Entrez Gene) Cadherin
CDH13GeneProduct1012 (Entrez Gene) Cadherin
CDH15GeneProduct1013 (Entrez Gene) Cadherin
CDH16GeneProduct1014 (Entrez Gene) Cadherin
CDH17GeneProduct1015 (Entrez Gene) Cadherin
CDH18GeneProduct1016 (Entrez Gene) Cadherin
CDH19GeneProduct28513 (Entrez Gene) Cadherin
CDH1GeneProduct999 (Entrez Gene) Cadherin
CDH20GeneProduct28316 (Entrez Gene) Cadherin
CDH2GeneProduct1000 (Entrez Gene) Cadherin
CDH22GeneProduct64405 (Entrez Gene) Cadherin
CDH24GeneProduct64403 (Entrez Gene) Cadherin
CDH3GeneProduct1001 (Entrez Gene) Cadherin
CDH4GeneProduct1002 (Entrez Gene) Cadherin
CDH5GeneProduct1003 (Entrez Gene) Cadherin
CDH6GeneProduct1004 (Entrez Gene) Cadherin
CDH7GeneProduct1005 (Entrez Gene) Cadherin
CDH8GeneProduct1006 (Entrez Gene) Cadherin
CDH9GeneProduct1007 (Entrez Gene) Cadherin
CSF1RGeneProductENSG00000182578 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978
CTNNB1GeneProduct1499 (Entrez Gene)
EGFRGeneProductENSG00000146648 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649
EPHA2GeneProductENSG00000142627 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836
Energy StressPathway
FGFR1GeneProductENSG00000077782 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182
FGFR2GeneProductENSG00000066468 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183
FGFR3GeneProductENSG00000068078 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184
FGFR4GeneProductENSG00000160867 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186
FLT1GeneProductENSG00000102755 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254
FLT3GeneProductENSG00000122025 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
FLT4GeneProductENSG00000037280 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
G Protein SignalingPathwayWP35 (WikiPathways)
GNA11GeneProduct2767 (Entrez Gene) Ga/1
GNAI2GeneProduct2771 (Entrez Gene) Ga/1
GNAI3GeneProduct2773 (Entrez Gene) Ga/1
GNALGeneProduct2774 (Entrez Gene) Ga/1
GNAQGeneProduct2776 (Entrez Gene) Ga/1
GNASGeneProduct2778 (Entrez Gene) Ga/1
IGF1RGeneProductENSG00000140443 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001
INSRGeneProductENSG00000171105 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
KDRGeneProductENSG00000128052 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542
KITGeneProductENSG00000157404 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590
LATS1GeneProduct9113 (Entrez Gene) LATS1/2
LATS2GeneProduct26524 (Entrez Gene) LATS1/2
LEF1GeneProductENSG00000138795 (Ensembl)
METGeneProductENSG00000105976 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295
MTORGeneProduct2475 (Entrez Gene) mTOR
Mevalonate PathwayPathwayWP3963 (WikiPathways)
NF2GeneProduct4771 (Entrez Gene) Nf2
NGFRGeneProductENSG00000064300 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18053
NTRK1GeneProductENSG00000198400 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
NTRK2GeneProductENSG00000148053 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
PDGFRAGeneProductENSG00000134853 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18595
PDGFRBGeneProductENSG00000113721 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18596
PI3K/AKT SignalingPathwayWP4172 (WikiPathways)
PLCB1GeneProduct23236 (Entrez Gene) PLCB
PLCB2GeneProduct5330 (Entrez Gene) PLCB
PLCB3GeneProduct5331 (Entrez Gene) PLCB
PLCB4GeneProduct5332 (Entrez Gene) PLCB
PRKAA1GeneProduct5562 (Entrez Gene) AMPK
PRKAA2GeneProduct5563 (Entrez Gene) AMPK
PRKAB1GeneProduct5564 (Entrez Gene) AMPK
PRKAB2GeneProduct5565 (Entrez Gene) AMPK
PRKACAGeneProduct5566 (Entrez Gene) PKA
PRKACBGeneProduct5567 (Entrez Gene) PKA
PRKACGGeneProduct5568 (Entrez Gene) PKA
PRKAG1GeneProduct5571 (Entrez Gene) AMPK
PRKAG2GeneProduct51422 (Entrez Gene) AMPK
PRKAG3GeneProduct53632 (Entrez Gene) AMPK
PRKAR1AGeneProduct5573 (Entrez Gene) PKA
PRKAR1BGeneProduct5575 (Entrez Gene) PKA
PRKAR2AGeneProduct5576 (Entrez Gene) PKA
PRKAR2BGeneProduct5577 (Entrez Gene) PKA
PRKCAGeneProduct5578 (Entrez Gene) PKC
PRKCBGeneProduct5579 (Entrez Gene) PKC
PRKCDGeneProduct5580 (Entrez Gene) PKC
PRKCEGeneProduct5581 (Entrez Gene) PKC
PRKCGGeneProduct5582 (Entrez Gene) PKC
PRKCHGeneProduct5583 (Entrez Gene) PKC
PRKCIGeneProduct5584 (Entrez Gene) PKC
PRKCQGeneProduct5588 (Entrez Gene) PKC
PRKCZGeneProduct5590 (Entrez Gene) PKC
PRKD3GeneProduct23683 (Entrez Gene) PKC
RAC1GeneProduct5879 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene) SMAD
SMAD3GeneProduct4088 (Entrez Gene) SMAD
STK3GeneProduct6788 (Entrez Gene) MST1/2
STK4GeneProduct4485 (Entrez Gene) MST1/2
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
TEAD1GeneProductENSG00000187079 (Ensembl)
TEAD2GeneProductENSG00000074219 (Ensembl)
TEAD3GeneProductENSG00000007866 (Ensembl)
TEAD4GeneProductENSG00000197905 (Ensembl)
TEKGeneProductENSG00000120156 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
TGF-Beta SignalingPathwayWP560 (WikiPathways)
WNT SignalingPathwayWP428 (WikiPathways)
WWTR1GeneProduct25937 (Entrez Gene)
YAP1GeneProduct10413 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4540"
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