Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms (Homo sapiens)

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1NucleoplasmActin filamentsCytoplasmAJ complexPAK3CTNNB1TEAD4STK3TEAD1WWTR1PAK4SAV1MAPK9MAP4K4NF2ITGB4TEAD2PAK1TEAD3MAP4K3ACTG2PAK6ITGB1STK4YAP1MAP4K1ACTA1PAK5SGMS1ACTG1ITGB5ITGB6ACTBMAPK10ITGB3MAP4K2LATS1MAP4K5CDH1PAK2YWHAQITGB2ACTA2ITGB8ACTC1ITGB7SRCLIMD1MAPK8PPPPPPCDH1NF2CTNNA1PActin cytoskeletona-catenina-cateninCDH1CTNNB1CDH1CTNNA1


Description

Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms. This pathway was created based on figure 2 from Dobrokhotov et al. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  2. Dobrokhotov O, Samsonov M, Sokabe M, Hirata H; ''Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms.''; Clin Transl Med, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134751view23:51, 26 July 2024EweitzStraighten lines
134750view23:40, 26 July 2024EweitzEconomize layout
127231view20:09, 25 August 2023Khanspersadded lit ref
127228view20:05, 25 August 2023KhanspersModified description
127226view20:03, 25 August 2023KhanspersModified description
127214view21:04, 17 August 2023Khanspersupdated YAP/TAZ, added phosphosites
103303view16:24, 21 February 2019FehrhartOntology Term : 'cancer' added !
103301view16:23, 21 February 2019FehrhartOntology Term : 'mechanotransduction pathway' added !
103297view16:19, 21 February 2019FehrhartOntology Term : 'Hippo signaling pathway' added !
103296view16:18, 21 February 2019Fehrhartadded last annotations
103293view16:03, 21 February 2019Fehrhartwork in progress
103289view15:33, 21 February 2019FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA1GeneProduct58 (Entrez Gene) Actin
ACTA2GeneProduct59 (Entrez Gene) Actin
ACTBGeneProduct60 (Entrez Gene) Actin
ACTC1GeneProduct70 (Entrez Gene) Actin
ACTG1GeneProduct71 (Entrez Gene) Actin
ACTG2GeneProduct72 (Entrez Gene) Actin
CDH1GeneProduct999 (Entrez Gene) E-cadherin
CTNNA1GeneProductENSG00000044115 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
ITGB2GeneProductENSG00000160255 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITGB4GeneProductENSG00000132470 (Ensembl)
ITGB5GeneProductENSG00000082781 (Ensembl)
ITGB6GeneProductENSG00000115221 (Ensembl)
ITGB7GeneProductENSG00000139626 (Ensembl)
ITGB8GeneProductENSG00000105855 (Ensembl)
LATS1GeneProduct9113 (Entrez Gene) LATS1/2MAP4Ks
LIMD1GeneProduct8994 (Entrez Gene) LIMD1
MAP4K1GeneProductENSG00000104814 (Ensembl)
MAP4K2GeneProductENSG00000168067 (Ensembl)
MAP4K3GeneProductENSG00000011566 (Ensembl)
MAP4K4GeneProductENSG00000071054 (Ensembl)
MAP4K5GeneProductENSG00000012983 (Ensembl)
MAPK10GeneProduct5602 (Entrez Gene) JNK
MAPK8GeneProduct5599 (Entrez Gene) JNK
MAPK9GeneProduct5601 (Entrez Gene) JNK
NF2GeneProduct4771 (Entrez Gene) Merlin
PAK1GeneProduct5058 (Entrez Gene) PAK
PAK2GeneProduct5062 (Entrez Gene) PAK
PAK3GeneProduct5063 (Entrez Gene) PAK
PAK4GeneProduct10298 (Entrez Gene) PAK
PAK5GeneProduct57144 (Entrez Gene) PAK
PAK6GeneProduct56924 (Entrez Gene) PAK
SAV1GeneProduct60485 (Entrez Gene) SAV1
SGMS1GeneProduct259230 (Entrez Gene) MOB
SRCGeneProduct6714 (Entrez Gene) Src
STK3GeneProduct6788 (Entrez Gene) MST1/2
STK4GeneProduct4485 (Entrez Gene) MST1/2
TEAD1GeneProduct7003 (Entrez Gene) TEAD1-4
TEAD2GeneProduct8463 (Entrez Gene) TEAD1-4
TEAD3GeneProduct7005 (Entrez Gene) TEAD1-4
TEAD4GeneProduct7004 (Entrez Gene) TEAD1-4
WWTR1GeneProduct25937 (Entrez Gene) YAP/TAZ
YAP1GeneProduct10413 (Entrez Gene) YAP/TAZ
YWHAQGeneProduct10971 (Entrez Gene) 14-3-3
a-cateninGeneProduct

Annotated Interactions

No annotated interactions

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