IDO metabolic pathway (Homo sapiens)

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1Anthranilic AcidKYNUKAT13-Hydroxyanthranilic AcidKynurenineQuinolinic AcidL-TryptophanPicolinic AcidNAD+Kynurenic Acid3-HydroxykynurenineKMOIDO1IDO2T23OKAT3AADATAATMKYNU


Description

Overview of the IDO metabolic pathway. Approximately 95% of L-tryptophan (Trp) is catabolized into kynurenine (Kyn) through three rate-limiting enzymes: tryptophan 2,3-dioxygenase (TDO) in the liver and indoleamine 2, 3-dioxygenase 1/2 (IDO1/2) in peripheral tissues. Kyn is converted to 3-hydroxykynurenine (3-HK) by kynurenine 3-monooxygenase (KMO), to anthranilic acid (AA) by kynureninase (KYNase), or to kynurenic acid (KYNA) by kynurenine aminotransferase (KAT). Next, catalyzed by KYNase, 3-HK is converted to 3-hydroxyanthranilic acid (3-HAA), which is further converted to quinolinic acid (QA), picolinic acid, nicotinamide adenine dinucleotide (NAD+), and other molecules. PFOCR entry: https://pfocr.wikipathways.org/figures/PMC6090955__13045_2018_644_Fig1_HTML.html

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Ontology Terms

 

Bibliography

  1. Liu M, Wang X, Wang L, Ma X, Gong Z, Zhang S, Li Y; ''Targeting the IDO1 pathway in cancer: from bench to bedside.''; J Hematol Oncol, 2018 PubMed Europe PMC Scholia
  2. Lawler NG, Gray N, Kimhofer T, Boughton B, Gay M, Yang R, Morillon AC, Chin ST, Ryan M, Begum S, Bong SH, Coudert JD, Edgar D, Raby E, Pettersson S, Richards T, Holmes E, Whiley L, Nicholson JK; ''Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses.''; J Proteome Res, 2021 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
127968view15:20, 20 January 2024EweitzStandardize case
127286view21:06, 1 September 2023Mkutmonadded missing identifier
127285view21:03, 1 September 2023Mkutmonremove unused ref
127284view21:01, 1 September 2023MkutmonModified description
127283view21:00, 1 September 2023Mkutmonadded some additional info from second paper
127282view20:35, 1 September 2023MkutmonModified description
127281view20:34, 1 September 2023MkutmonModified description
127280view20:22, 1 September 2023MkutmonOntology Term : 'tryptophan metabolic pathway' added !
127279view20:20, 1 September 2023MkutmonOntology Term : 'classic metabolic pathway' added !
127278view20:20, 1 September 2023MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-Hydroxyanthranilic AcidMetaboliteCHEBI:15793 (ChEBI)
3-HydroxykynurenineMetaboliteCHEBI:1547 (ChEBI)
AADATProteinQ8N5Z0 (Uniprot-TrEMBL)
AATMProteinP00505 (Uniprot-TrEMBL)
Anthranilic AcidMetaboliteCHEBI:30754 (ChEBI)
IDO1ProteinP14902 (Uniprot-TrEMBL)
IDO2ProteinQ6ZQW0 (Uniprot-TrEMBL)
KAT1ProteinQ16773 (Uniprot-TrEMBL)
KAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KMOProteinO15229 (Uniprot-TrEMBL)
KYNUProteinQ16719 (Uniprot-TrEMBL)
Kynurenic AcidMetaboliteCHEBI:18344 (ChEBI)
KynurenineMetaboliteCHEBI:57959 (ChEBI)
L-TryptophanMetaboliteCHEBI:16828 (ChEBI)
NAD+MetaboliteCHEBI:13389 (ChEBI)
Picolinic AcidMetaboliteCHEBI:28747 (ChEBI)
Quinolinic AcidMetaboliteCHEBI:16675 (ChEBI)
T23OProteinP48775 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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