Cell lineage map for neuronal differentiation (Mus musculus)

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Stem CellAp2a2Sox9Evx1Slc1a3Homer1GfapSypPecam1Dppa3Cldn11Lin7aHes5Ppfia1Twist1CnpTubb3TUnc13aCacng2Aqp4NeflGlsS100bSlc6a3Pou5f1ErasFoxa2TncAdra2aErc1Snai2Dppa2Rbfox3Glra1Glra2GlrbMsx2Homer2Glra3Snap25NodalDlg3Rims2Htr5aAcheSox10Pax3Slc1a2Hnf4aFbxo15Ap2a1CD34Fabp7Adra2cCspg4Slc18a3Slc6a4Homer3Itga6Sox17Grin1NanogNr4a2Gabbr2Gabbr1Nlgn1Notch1Snai1Sox2Tph1MbpLmx1bSlc6a5Krt15GphnShank1Hes3Grin2bGata4Itgb1Mixl1Robo1Slc6a2Fgf4DcxTbr1ThOlig2Gad2BsnGad1ChatFoxd3FevAdra2bDlg1Pax6Slc6a9Slc6a1Gata6Bmp4Glra4Twist2Hes1Rimbp2NesDll1Lef1Cdh2Cdh1Slc17a6EsrrbMap2MogLhx1PcloGlulShank3Aldh1l1Cd24aKlf4Dlg2Msx1NgfrCaskKcnj6Fut4Foxa2Tpm1NefmZfp42Htr1aDlg4Slc17a7EctodermMesodermEndodermNeural progenitorNon-neural ectodermNeural crestImmature neuronAstrocyteOligodendrocyteMature neuronPre-synapsePost-synapseGlutamatergicGABAergicGlycinergicCholinergicDopaminergicNoradrenergicSerotonergic


Description

This cell lineage map consists of a set of cell types emerging during neural differentiation.

A selection of cell type-specific markers was made based on literature (e.g. Beccari et al., 2018, https://doi.org/10.1038/s41586-018-0578-0; Kügler et al., 2010, https://doi.org/10.14573/altex.2010.1.16; Spangler et al., 2018, https://doi.org/10.1016/j.scr.2018.07.022; Tao and Zhang, 2016, https://doi.org/10.1016/j.stem.2016.10.015) to distinguish these different cell types. This map was published in: Victoria de Leeuw et al., 2020, NeuroToxicology 76, 1-9. https://doi.org/10.1016/j.neuro.2019.09.014.

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Ontology Terms

 

Bibliography

  1. ''Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids''; , DOI Scholia
  2. ''Markers of murine embryonic and neural stem cells, neurons and astrocytes: Reference points for developmental neurotoxicity testing ''; , DOI Scholia
  3. ''A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo''; , DOI Scholia
  4. ''Neural Subtype Specification from Human Pluripotent Stem Cells''; , DOI Scholia
  5. ''Differential effects of fluoxetine and venlafaxine in the neural embryonic stem cell test (ESTn) revealed by a cell lineage map''; , DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
127427view10:16, 1 October 2023EgonwAdded the DOIs as literature references
127422view09:54, 1 October 2023EgonwOntology Term : 'regulatory pathway' added !
127421view09:54, 1 October 2023EgonwOntology Term : 'neuron' added !
127323view08:55, 14 September 2023PenningsModified description
127319view08:48, 14 September 2023PenningsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcheGeneProductENSMUSG00000023328 (Ensembl)
Adra2aGeneProductENSMUSG00000033717 (Ensembl)
Adra2bGeneProductENSMUSG00000058620 (Ensembl)
Adra2cGeneProductENSMUSG00000045318 (Ensembl)
Aldh1l1GeneProductENSMUSG00000030088 (Ensembl)
Ap2a1GeneProductENSMUSG00000060279 (Ensembl)
Ap2a2GeneProductENSMUSG00000002957 (Ensembl)
Aqp4GeneProductENSMUSG00000024411 (Ensembl)
Bmp4GeneProductENSMUSG00000021835 (Ensembl)
BsnGeneProductENSMUSG00000032589 (Ensembl)
CD34GeneProductENSMUSG00000016494 (Ensembl)
Cacng2GeneProductENSMUSG00000019146 (Ensembl)
CaskGeneProductENSMUSG00000031012 (Ensembl)
Cd24aGeneProductENSMUSG00000047139 (Ensembl)
Cdh1GeneProductENSMUSG00000000303 (Ensembl)
Cdh2GeneProductENSMUSG00000024304 (Ensembl)
ChatGeneProductENSMUSG00000021919 (Ensembl)
Cldn11GeneProductENSMUSG00000037625 (Ensembl)
CnpGeneProductENSMUSG00000006782 (Ensembl)
Cspg4GeneProductENSMUSG00000032911 (Ensembl)
DcxGeneProductENSMUSG00000031285 (Ensembl)
Dlg1GeneProductENSMUSG00000022770 (Ensembl)
Dlg2GeneProductENSMUSG00000052572 (Ensembl)
Dlg3GeneProductENSMUSG00000000881 (Ensembl)
Dlg4GeneProductENSMUSG00000020886 (Ensembl)
Dll1GeneProductENSMUSG00000014773 (Ensembl)
Dppa2GeneProductENSMUSG00000072419 (Ensembl)
Dppa3GeneProductENSMUSG00000046323 (Ensembl)
ErasGeneProductENSMUSG00000031160 (Ensembl)
Erc1GeneProductENSMUSG00000030172 (Ensembl)
EsrrbGeneProductENSMUSG00000021255 (Ensembl)
Evx1GeneProductENSMUSG00000005503 (Ensembl)
Fabp7GeneProductENSMUSG00000019874 (Ensembl)
Fbxo15GeneProductENSMUSG00000034391 (Ensembl)
FevGeneProductENSMUSG00000055197 (Ensembl)
Fgf4GeneProductENSMUSG00000050917 (Ensembl)
Foxa2GeneProductENSMUSG00000037025 (Ensembl)
Foxd3GeneProductENSMUSG00000067261 (Ensembl)
Fut4GeneProductENSMUSG00000049307 (Ensembl)
Gabbr1GeneProductENSMUSG00000024462 (Ensembl)
Gabbr2GeneProductENSMUSG00000039809 (Ensembl)
Gad1GeneProductENSMUSG00000070880 (Ensembl)
Gad2GeneProductENSMUSG00000026787 (Ensembl)
Gata4GeneProductENSMUSG00000021944 (Ensembl)
Gata6GeneProductENSMUSG00000005836 (Ensembl)
GfapGeneProductENSMUSG00000020932 (Ensembl)
Glra1GeneProductENSMUSG00000000263 (Ensembl)
Glra2GeneProductENSMUSG00000018589 (Ensembl)
Glra3GeneProductENSMUSG00000038257 (Ensembl)
Glra4GeneProductENSMUSG00000018595 (Ensembl)
GlrbGeneProductENSMUSG00000028020 (Ensembl)
GlsGeneProductENSMUSG00000026103 (Ensembl)
GlulGeneProductENSMUSG00000026473 (Ensembl)
GphnGeneProductENSMUSG00000047454 (Ensembl)
Grin1GeneProductENSMUSG00000026959 (Ensembl)
Grin2bGeneProductENSMUSG00000030209 (Ensembl)
Hes1GeneProductENSMUSG00000022528 (Ensembl)
Hes3GeneProductENSMUSG00000028946 (Ensembl)
Hes5GeneProductENSMUSG00000048001 (Ensembl)
Hnf4aGeneProductENSMUSG00000017950 (Ensembl)
Homer1GeneProductENSMUSG00000007617 (Ensembl)
Homer2GeneProductENSMUSG00000025813 (Ensembl)
Homer3GeneProductENSMUSG00000003573 (Ensembl)
Htr1aGeneProductENSMUSG00000021721 (Ensembl)
Htr5aGeneProductENSMUSG00000039106 (Ensembl)
Itga6GeneProductENSMUSG00000027111 (Ensembl)
Itgb1GeneProductENSMUSG00000025809 (Ensembl)
Kcnj6GeneProductENSMUSG00000043301 (Ensembl)
Klf4GeneProductENSMUSG00000003032 (Ensembl)
Krt15GeneProductENSMUSG00000054146 (Ensembl)
Lef1GeneProductENSMUSG00000027985 (Ensembl)
Lhx1GeneProductENSMUSG00000018698 (Ensembl)
Lin7aGeneProductENSMUSG00000019906 (Ensembl)
Lmx1bGeneProductENSMUSG00000038765 (Ensembl)
Map2GeneProductENSMUSG00000015222 (Ensembl)
MbpGeneProductENSMUSG00000041607 (Ensembl)
Mixl1GeneProductENSMUSG00000026497 (Ensembl)
MogGeneProductENSMUSG00000076439 (Ensembl)
Msx1GeneProductENSMUSG00000048450 (Ensembl)
Msx2GeneProductENSMUSG00000021469 (Ensembl)
NanogGeneProductENSMUSG00000012396 (Ensembl)
NeflGeneProductENSMUSG00000022055 (Ensembl)
NefmGeneProductENSMUSG00000022054 (Ensembl)
NesGeneProductENSMUSG00000004891 (Ensembl)
NgfrGeneProductENSMUSG00000000120 (Ensembl)
Nlgn1GeneProductENSMUSG00000063887 (Ensembl)
NodalGeneProductENSMUSG00000037171 (Ensembl)
Notch1GeneProductENSMUSG00000026923 (Ensembl)
Nr4a2GeneProductENSMUSG00000026826 (Ensembl)
Olig2GeneProductENSMUSG00000039830 (Ensembl)
Pax3GeneProductENSMUSG00000004872 (Ensembl)
Pax6GeneProductENSMUSG00000027168 (Ensembl)
PcloGeneProductENSMUSG00000061601 (Ensembl)
Pecam1GeneProductENSMUSG00000020717 (Ensembl)
Pou5f1GeneProductENSMUSG00000024406 (Ensembl)
Ppfia1GeneProductENSMUSG00000037519 (Ensembl)
Rbfox3GeneProductENSMUSG00000025576 (Ensembl)
Rimbp2GeneProductENSMUSG00000029420 (Ensembl)
Rims2GeneProductENSMUSG00000037386 (Ensembl)
Robo1GeneProductENSMUSG00000022883 (Ensembl)
S100bGeneProductENSMUSG00000033208 (Ensembl)
Shank1GeneProductENSMUSG00000038738 (Ensembl)
Shank3GeneProductENSMUSG00000022623 (Ensembl)
Slc17a6GeneProductENSMUSG00000030500 (Ensembl)
Slc17a7GeneProductENSMUSG00000070570 (Ensembl)
Slc18a3GeneProductENSMUSG00000100241 (Ensembl)
Slc1a2GeneProductENSMUSG00000005089 (Ensembl)
Slc1a3GeneProductENSMUSG00000005360 (Ensembl)
Slc6a1GeneProductENSMUSG00000030310 (Ensembl)
Slc6a2GeneProductENSMUSG00000055368 (Ensembl)
Slc6a3GeneProductENSMUSG00000021609 (Ensembl)
Slc6a4GeneProductENSMUSG00000020838 (Ensembl)
Slc6a5GeneProductENSMUSG00000039728 (Ensembl)
Slc6a9GeneProductENSMUSG00000028542 (Ensembl)
Snai1GeneProductENSMUSG00000042821 (Ensembl)
Snai2GeneProductENSMUSG00000022676 (Ensembl)
Snap25GeneProductENSMUSG00000027273 (Ensembl)
Sox10GeneProductENSMUSG00000033006 (Ensembl)
Sox17GeneProductENSMUSG00000025902 (Ensembl)
Sox2GeneProductENSMUSG00000074637 (Ensembl)
Sox9GeneProductENSMUSG00000000567 (Ensembl)
SypGeneProductENSMUSG00000031144 (Ensembl)
TGeneProductENSMUSG00000062327 (Ensembl)
Tbr1GeneProductENSMUSG00000035033 (Ensembl)
ThGeneProductENSMUSG00000000214 (Ensembl)
TncGeneProductENSMUSG00000028364 (Ensembl)
Tph1GeneProductENSMUSG00000040046 (Ensembl)
Tpm1GeneProductENSMUSG00000032366 (Ensembl)
Tubb3GeneProductENSMUSG00000062380 (Ensembl)
Twist1GeneProductENSMUSG00000035799 (Ensembl)
Twist2GeneProductENSMUSG00000007805 (Ensembl)
Unc13aGeneProductENSMUSG00000034799 (Ensembl)
Zfp42GeneProductENSMUSG00000051176 (Ensembl)

Annotated Interactions

No annotated interactions

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