Cholestasis (Homo sapiens)
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Description
Genetic causes of cholestasis
Quality Tags
Ontology Terms
Bibliography
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- Kassam A, Miao B, Young PR, Mukherjee R; ''Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
- Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B; ''Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
- Yu L, Gupta S, Xu F, Liverman AD, Moschetta A, Mangelsdorf DJ, Repa JJ, Hobbs HH, Cohen JC; ''Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
- Renga B, Migliorati M, Mencarelli A, Cipriani S, D'Amore C, Distrutti E, Fiorucci S; ''Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4promoter.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
- Fiorucci S, Zampella A, Distrutti E; ''Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disorders.''; Curr Top Med Chem, 2012 PubMed Europe PMC Scholia
- Gautherot J, Claudel T, Cuperus F, Fuchs CD, Falguières T, Trauner M; ''Thyroid hormone receptor β1 stimulatesABCB4to increase biliary phosphatidylcholine excretion in mice.''; J Lipid Res, 2018 PubMed Europe PMC Scholia
- Friesen JA, Rodwell VW; ''The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.''; Genome Biol, 2004 PubMed Europe PMC Scholia
- Chiang JY; ''Bile acid metabolism and signaling.''; Compr Physiol, 2013 PubMed Europe PMC Scholia
- Chang TY, Chang CC, Ohgami N, Yamauchi Y; ''Cholesterol sensing, trafficking, and esterification.''; Annu Rev Cell Dev Biol, 2006 PubMed Europe PMC Scholia
- More VR, Campos CR, Evans RA, Oliver KD, Chan GN, Miller DS, Cannon RE; ''PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression.''; J Cereb Blood Flow Metab, 2017 PubMed Europe PMC Scholia
- Zollner G, Fickert P, Fuchsbichler A, Silbert D, Wagner M, Arbeiter S, Gonzalez FJ, Marschall HU, Zatloukal K, Denk H, Trauner M; ''Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine.''; J Hepatol, 2003 PubMed Europe PMC Scholia
- Eloranta JJ, Kullak-Ublick GA; ''The role of FXR in disorders of bile acid homeostasis.''; Physiology (Bethesda), 2008 PubMed Europe PMC Scholia
- Chang TY, Li BL, Chang CC, Urano Y; ''Acyl-coenzyme A:cholesterol acyltransferases.''; Am J Physiol Endocrinol Metab, 2009 PubMed Europe PMC Scholia
- Ding L, Yang L, Wang Z, Huang W; ''Bile acid nuclear receptor FXR and digestive system diseases.''; Acta Pharm Sin B, 2015 PubMed Europe PMC Scholia
- Ghonem NS, Ananthanarayanan M, Soroka CJ, Boyer JL; ''Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion.''; Hepatology, 2014 PubMed Europe PMC Scholia
- Kim I, Ahn SH, Inagaki T, Choi M, Ito S, Guo GL, Kliewer SA, Gonzalez FJ; ''Differential regulation of bile acid homeostasis by the farnesoid X receptor in liverand intestine.''; J Lipid Res, 2007 PubMed Europe PMC Scholia
- Hiebl V, Ladurner A, Latkolik S, Dirsch VM; ''Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR.''; Biotechnol Adv, 2018 PubMed Europe PMC Scholia
- Dong B, Singh AB, Guo GL, Young M, Liu J; ''Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR.''; Int J Mol Med, 2019 PubMed Europe PMC Scholia
- Koh S, Takada T, Kukuu I, Suzuki H; ''FIC1-mediated stimulation of FXR activity is decreased with PFIC1 mutations in HepG2 cells.''; J Gastroenterol, 2009 PubMed Europe PMC Scholia
- Moffit JS, Aleksunes LM, Maher JM, Scheffer GL, Klaassen CD, Manautou JE; ''Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha.''; J Pharmacol Exp Ther, 2006 PubMed Europe PMC Scholia
- Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA; ''Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
- Huang L, Zhao A, Lew JL, Zhang T, Hrywna Y, Thompson JR, de Pedro N, Royo I, Blevins RA, Peláez F, Wright SD, Cui J; ''Farnesoid X receptor activates transcription of the phospholipid pump MDR3.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ABCB11 | Protein | O95342 (Uniprot-TrEMBL) |
|
ABCB4 | Protein | P21439 (Uniprot-TrEMBL) | Multidrug resistance protein 3 |
ABCC2 | Protein | Q92887 (Uniprot-TrEMBL) | Multidrug resistance-associated protein 2 |
ABCG5 | Protein | Q9H222 (Uniprot-TrEMBL) | |
ABCG8 | Protein | Q9H221 (Uniprot-TrEMBL) | |
ATP8B1 | Protein | O43520 (Uniprot-TrEMBL) | familial intrahepatic cholestasis 1 |
Acetyl CoA | Metabolite | 15351 (ChEBI) | |
Ba | Metabolite | CHEBI:22868 (ChEBI) | |
Bile acid | Metabolite | 3098 (ChEBI) | |
Bile canaliculus | |||
Cations | Metabolite | CHEBI:25697 (ChEBI) | |
Chol | Metabolite | CHEBI:16113 (ChEBI) | |
Cholesterol | Metabolite | CHEBI:16113 (ChEBI) | |
Cholesteryl esters | Metabolite | CHEBI:17002 (ChEBI) | |
GSH | Metabolite | CHEBI:16856 (ChEBI) | |
HCO3(-) | Metabolite | CHEBI:17544 (ChEBI) | |
HDL | Metabolite | CHEBI:39025 (ChEBI) | |
HMGCR | GeneProduct | P04035 (Uniprot-TrEMBL) | |
LDL | Metabolite | CHEBI:39026 (ChEBI) | |
LDLR | Protein | P01130 (Uniprot-TrEMBL) | microsomal epoxide hydrolase |
MRP3 | Protein | O15438 (Uniprot-TrEMBL) | Multidrug resistance associated protein 3 |
MRP4 | Protein | O15439 (Uniprot-TrEMBL) | Multidrug resistance associated protein 4 |
NR1H4 | Protein | Q96RI1 (Uniprot-TrEMBL) | Farnesoid X Receptor |
NR1I3 | GeneProduct | ENSG00000143257 (Ensembl) | |
NTCP | Protein | Q14973 (Uniprot-TrEMBL) | sodium/bile acid cotransporter |
Na+ | Metabolite | CHEBI:29101 (ChEBI) | |
OATPs | Protein | P46721 (Uniprot-TrEMBL) | Solute carrier organic anion transporter family member |
OCT1 | Protein | O15245 (Uniprot-TrEMBL) | Organic cation transporter 1 |
PPAR-a | Metabolite | CHEBI:70782 (ChEBI) | |
Phospholipids | Metabolite | CHEBI:16247 (ChEBI) | |
RXRA | Protein | P19793 (Uniprot-TrEMBL) | Retinoid X receptor |
Regulation of BA synthesis and transport | Pathway | WP5176 (WikiPathways) | |
SR-B1 | Protein | Q8WTV0 (Uniprot-TrEMBL) | Scavenger receptor class B member 1 |
TJP2 | Protein | Q9UDY2 (Uniprot-TrEMBL) | Tight junction protein ZO-2 |
Tight junction | Complex | Q1053832 (Wikidata) | |
mEH | Protein | P07099 (Uniprot-TrEMBL) | microsomal epoxide hydrolase |
Annotated Interactions
No annotated interactions