EPAC1 and PKA reduction of retinal inflammation (Homo sapiens)

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1LegendPKADiabetic retinopathyMainly in cytosolEPAC1NEK7PRKACAPRKACBPRKAR1ANLRP3IL1BPKA type IPKAPRKAR2BPRKACAPRKACBPRKAR2APKA type IIPRKAR1BMainly bound to membranes and microtubulesRetinal inflammation


Description

Liu et al. (2022) note: "PKA and Epac1 regulated Nek7/NLRP3 signaling proteins. The schematic depicts the signaling pathway of PKA and Epac1 inhibition of Nek7 and NLRP3 signaling proteins to reduce retinal inflammation." This pathway diagram was derived from https://pfocr.wikipathways.org/figures/PMC8762717__iovs-63-1-14-f009.html.

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Ontology Terms

 

Bibliography

  1. Liu L, Jiang Y, Steinle JJ; ''PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature.''; Invest Ophthalmol Vis Sci, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128375view18:13, 3 February 2024Ash iyerUpdate previous again.
128374view17:59, 3 February 2024Ash iyerFixed graphical elements out of bound
128341view02:55, 2 February 2024EweitzFix Ensembl ID for PRKAR2A
128340view02:52, 2 February 2024EweitzRefine node type, gene database
128339view02:43, 2 February 2024EweitzModified description
128338view02:42, 2 February 2024EweitzDelete a pathway comment; moving to description
128320view23:52, 31 January 2024EweitzOntology Term : 'protein kinase A (PKA) signaling pathway' added !
128314view22:23, 31 January 2024EweitzOntology Term : 'diabetic retinopathy' added !
128313view22:21, 31 January 2024EweitzRefine literature reference
128309view13:59, 31 January 2024EweitzNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
EPAC1GeneProduct10411 (Entrez Gene)
IL1BGeneProductENSG00000125538 (Ensembl)
NEK7GeneProductENSG00000151414 (Ensembl)
NLRP3GeneProductENSG00000162711 (Ensembl)
PRKACAGeneProductENSG00000288516 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKAR1AGeneProductENSG00000108946 (Ensembl)
PRKAR1BGeneProductENSG00000188191 (Ensembl)
PRKAR2AGeneProductENSG00000114302 (Ensembl)
PRKAR2BGeneProductENSG00000188191 (Ensembl)

Annotated Interactions

No annotated interactions

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