Mitochondrial complex inhibition leading to liver injury (Homo sapiens)
From WikiPathways
Description
This is the AOP represented in https://aopwiki.org/aops/273: Mitochondrial complex inhibition leading to liver injury.
Quality Tags
Ontology Terms
Bibliography
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History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Amiodarone | |||
Antimycin A1 | |||
Apoptosis | Pathway | WP1772 (WikiPathways) | |
Assembly of mitochondrial complex III | Pathway | WP4921 (WikiPathways) | |
Assembly of mitochondrial complex IV | Pathway | WP4922 (WikiPathways) | |
Assembly of mitochondrial complex I | Pathway | WP4324 (WikiPathways) | |
Aurovertin | |||
Autophagy | Pathway | WP4923 (WikiPathways) | |
Benzbromarone | |||
Diclofenac sodium | |||
Electron Transport Chain (oxidative phosphorylation) | Pathway | WP111 (WikiPathways) | |
Entacapone | |||
Fenpyroximate | |||
Ferroptosis | Pathway | WP4313 (WikiPathways) | |
Impaired proteostasis | Pathway | WP4918 (WikiPathways) | |
KCN | |||
KE1542: Mitochondrial Complex III antagonism | Event | 1542 (AOP-Wiki KE) | |
KE1543: Mitochondrial Complex IV inhibition | Event | 1543 (AOP-Wiki KE) | |
KE1544: Mitochondrial Complex V inhibition | Event | 1544 (AOP-Wiki KE) | |
KE1545: Decrease in mitochondrial phosphorilation | Event | 1545 (AOP-Wiki KE) | |
KE1548: Necrotic tissue | Event | 1548 (AOP-Wiki KE) | |
KE1549: Liver injury | Event | 1549 (AOP-Wiki KE) | |
KE1653: Binding of inhibitor to mitochondrial complex III | Event | 1653 (AOP-Wiki KE) | |
KE1654: Binding of inhibitor to mitochondrial complex IV | Event | 1654 (AOP-Wiki KE) | |
KE1655: Binding of inhibitor to mitochondrial complex V | Event | 1655 (AOP-Wiki KE) | |
KE177: N/A, Mitochondrial dysfunction 1 | Event | 177 (AOP-Wiki KE) | |
KE55: N/A, Cell injury/death | Event | 55 (AOP-Wiki KE) | |
KE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I) | Event | 887 (AOP-Wiki KE) | |
KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) | Event | 888 (AOP-Wiki KE) | |
KE889: Impaired, Proteostasis | Event | 889 (AOP-Wiki KE) | |
Metformin | |||
Necrosis | Pathway | WP5022 (WikiPathways) | |
Nefazodone | |||
Oligomycin | |||
Pyridaben | |||
Rotenone | |||
Unfolded Protein Response | Pathway | WP4925 (WikiPathways) |
Annotated Interactions
No annotated interactions