Thyroid hormones production and peripheral downstream signaling effects (Homo sapiens)

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Gene product6ER3628461181323222063220525613178452534446282229262528441215254423628102421471622466422413154417133424274334466383628164472832232734253962413164422271322628289221810522264404419224522828482, 3762844225192254402745144434152942245132225441344184192431142843287135429131551347222416, 332229441324Cell cycle arrestCell survivalmTORGlucose transportMAPK signallingCell growth, proliferationand protein synthesisEndocytoseNeuronTranslocationApical membraneAHNFFAmim-cleavageARCHypothalamusCold or overfeedingmim-inhibitionThyroid follicular cellFollicular lumenAnterior pituitaryProliferative signallingProduction of DIO1, DIO2 and DIO3mim-binding PVNGs stimulationGlutathione metabolismNodesSpontaneous crosslinkingPreoptic areaNucleusERBasalmembraneData node for a gene product which mutation result in CHLiverNucleusEdgesPancreasLegendLipolysisCell differentiationmim-catalyzationmim-stimulationData node for a metaboliteNucleusData node for a pathwayHeat productionin brown ATCell proliferationBloodData node for a gene or its productGrowthDifferentiationTH productionProteolytic cleavageNucleusGq stimulationmim-conversionB cell maturationTo liverphosphorylationInsulin secretionTREGs stimulationSympathetic nervous systemGlial cellLipid dropletAdipose tissueHypoxiaPOMCiodidePKGAS160NOTCH signalingSLC26A4PRDM16ATF2PAX8NOTCHDIO1T3MITFGF21MCT8ZNF516GRB2Adenylate cyclaseTSC2RPS6KB1ITGBCREBRHEBMDM2MKK3BNPMAFAT4RHEBmTORFOXO1GSK3BTCA cycleTG bound MIT, DIT, T3 and T4S6DAGSHHNP-RT3PPARGTHRSLCO1C1B-CateninASK1TSHRNorepinephrineT4T3UCP1TBG bound T4NHSLPKCMEKT4BADTTF1ERKSECISBP2LWntRASANPFRS2AKTWnt signalingTGAGRPJMJD1BT3NADP+RAF1TGPLINcAMPAQP7TSC1p38MGLLITGAH+IP3SLC16A10IP3RDUOXA2FFARAPTORSIRT6SRCRasMLST8TPOtRNAsecSLC5A5TSC2FGFR1T3TSHKDM1APFKFB2ATGLNa+IYDPIP3PRAS40DUOX2PKAKLBRXRMC4RH2O2CASP9NADPHACcGMPiodideAlbumin bound T4CREBInflammationmTORTTR bound T4Oxidative phosphorylationGlycerolPCG-1Beta-3 ARTTF2TRHoxygenHypothalamic AMPK ACTL6BPI3KCa2+P53THRB1mTORSOSRPS6KA6NPYiodidePLCTG bound MIT and DITTG bound MIT, DIT, T3 and T4TBG bound T3Albumin bound T3TTR bound T3MCT8cAMPPKAphosphorylationDGMG1515FGF214444phosphorylation44phosphorylationphosphorylationUCP14MCT8MCT8DIO2T4T3DIO2MCT8MCT8T3T2SHHDIO3NucleusT3SLC16A107ITGBITGA3030T330THRA1213623742Glucose metabolismDAGPKCIP3IP3RCa2+PLC1313131313cAMP13PKA13, 41THRRXRNucleusT3MCT8T4MCT8T4T3DIO2Na+RXRT3THRB1iodideDITT3THRRXRT3Proliferative signalling27H+T32, 37Norepinephrine2, 37TRETRETREMetabolite6Gene productPathway


Description

Congenital hypothyroidism is a genetic hormonal disorder regarding the thyroid hormone. Due dyshormonogenesis, the production of the thyroid hormones is impaired resulting in increased birth weight, reduced LDL breakdown, decreased lipolysis, impaired glucose metabolism and decreased body temperature. Above, an overview of thyroid hormones production occurring in thyroid gland and their relevant downstream signalling is displayed. As the legend states, genes known te be affected by mutations leading to congenital hypothyroidism are colored red.

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Bibliography

View all...
  1. Mao LM, Tang Q, Wang JQ; ''Protein kinase C-regulated cAMP response element-binding protein phosphorylation in cultured rat striatal neurons.''; Brain Res Bull, 2007 PubMed Europe PMC Scholia
  2. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME; ''Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.''; Cell, 1997 PubMed Europe PMC Scholia
  3. Song Y, Driessens N, Costa M, De Deken X, Detours V, Corvilain B, Maenhaut C, Miot F, Van Sande J, Many MC, Dumont JE; ''Roles of hydrogen peroxide in thyroid physiology and disease.''; J Clin Endocrinol Metab, 2007 PubMed Europe PMC Scholia
  4. Frühbeck G, Méndez-Giménez L, Fernández-Formoso JA, Fernández S, Rodríguez A; ''Regulation of adipocyte lipolysis.''; Nutr Res Rev, 2014 PubMed Europe PMC Scholia
  5. Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S; ''Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  6. Rokita SE, Adler JM, McTamney PM, Watson JA Jr; ''Efficient use and recycling of the micronutrient iodide in mammals.''; Biochimie, 2010 PubMed Europe PMC Scholia
  7. Mariotta L, Ramadan T, Singer D, Guetg A, Herzog B, Stoeger C, Palacín M, Lahoutte T, Camargo SM, Verrey F; ''T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control.''; J Physiol, 2012 PubMed Europe PMC Scholia
  8. Gałecka E, Talarowska M, Maes M, Su KP, Górski P, Szemraj J; ''Polymorphisms of iodothyronine deiodinases (DIO1, DIO3) genes are not associated with recurrent depressive disorder.''; Pharmacol Rep, 2016 PubMed Europe PMC Scholia
  9. Dumitrescu AM, Refetoff S; ''Inherited defects of thyroid hormone metabolism.''; Ann Endocrinol (Paris), 2011 PubMed Europe PMC Scholia
  10. Spirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M; ''Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treatedwith sorafenib.''; Hepatology, 2012 PubMed Europe PMC Scholia
  11. Huang H, Shi Y, Liang B, Cai H, Cai Q; ''Iodinated TG in Thyroid Follicular Lumen Regulates TTF-1 and PAX8 Expression via TSH/TSHR Signaling Pathway.''; J Cell Biochem, 2017 PubMed Europe PMC Scholia
  12. Feliciello A, Allevato G, Musti AM, De Brasi D, Gallo A, Avvedimento VE, Gottesman ME; ''Thyroid transcription factor 1 phosphorylation is not required for protein kinase A-dependent transcription of the thyroglobulin promoter.''; Cell Growth Differ, 2000 PubMed Europe PMC Scholia
  13. Davis PJ, Davis FB, Lin HY; ''Promotion by thyroid hormone of cytoplasm-to-nucleus shuttling of thyroid hormone receptors.''; Steroids, 2008 PubMed Europe PMC Scholia
  14. Lebeck J; ''Metabolic impact of the glycerol channelsAQP7 and AQP9 in adipose tissue and liver.''; J Mol Endocrinol, 2014 PubMed Europe PMC Scholia
  15. Villarroya F, Peyrou M, Giralt M; ''Transcriptional regulation of the uncoupling protein-1 gene.''; Biochimie, 2017 PubMed Europe PMC Scholia
  16. Contreras C, Nogueiras R, Diéguez C, Rahmouni K, López M; ''Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.''; Redox Biol, 2017 PubMed Europe PMC Scholia
  17. López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A; ''Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance.''; Nat Med, 2010 PubMed Europe PMC Scholia
  18. Bartalena L, Robbins J; ''Thyroid hormone transport proteins.''; Clin Lab Med, 1993 PubMed Europe PMC Scholia
  19. Cvoro A, Devito L, Milton FA, Noli L, Zhang A, Filippi C, Sakai K, Suh JH, H Sieglaff D, Dhawan A, Sakai T, Ilic D, Webb P; ''A thyroid hormone receptor/KLF9 axis in human hepatocytes and pluripotent stem cells.''; Stem Cells, 2015 PubMed Europe PMC Scholia
  20. Schakman O, Kalista S, Bertrand L, Lause P, Verniers J, Ketelslegers JM, Thissen JP; ''Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats.''; Endocrinology, 2008 PubMed Europe PMC Scholia
  21. Mîinea CP, Sano H, Kane S, Sano E, Fukuda M, Peränen J, Lane WS, Lienhard GE; ''AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.''; Biochem J, 2005 PubMed Europe PMC Scholia
  22. Kouidhi S, Clerget-Froidevaux MS; ''Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk Between Nuclear Receptors.''; Int J Mol Sci, 2018 PubMed Europe PMC Scholia
  23. Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F; ''Thermogenic activation induces FGF21 expression and release in brown adipose tissue.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  24. Calebiro D, Nikolaev VO, Lohse MJ; ''Imaging of persistent cAMP signaling byinternalized G protein-coupled receptors.''; J Mol Endocrinol, 2010 PubMed Europe PMC Scholia
  25. Fenzl A, Kiefer FW; ''Brown adipose tissue and thermogenesis.''; Horm Mol Biol Clin Investig, 2014 PubMed Europe PMC Scholia
  26. Ahad F, Ganie SA; ''''; , PubMed Europe PMC Scholia
  27. Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP; ''Natriuretic peptides in cardiometabolic regulation and disease.''; Nat Rev Cardiol, 2014 PubMed Europe PMC Scholia
  28. Schwartz CE, Stevenson RE; ''''; , PubMed Europe PMC Scholia
  29. Miller LD, Park KS, Guo QM, Alkharouf NW, Malek RL, Lee NH, Liu ET, Cheng SY; ''Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation.''; Mol Cell Biol, 2001 PubMed Europe PMC Scholia
  30. Cheng SY, Leonard JL, Davis PJ; ''Molecular aspects of thyroid hormone actions.''; Endocr Rev, 2010 PubMed Europe PMC Scholia
  31. Cheng AW, Bolognesi M, Kraus VB; ''DIO2 modifies inflammatory responses in chondrocytes.''; Osteoarthritis Cartilage, 2012 PubMed Europe PMC Scholia
  32. Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D; ''Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  33. Kooijman S, van den Heuvel JK, Rensen PCN; ''Neuronal Control of Brown Fat Activity.''; Trends Endocrinol Metab, 2015 PubMed Europe PMC Scholia
  34. Bizhanova A, Kopp P; ''Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid.''; Endocrinology, 2009 PubMed Europe PMC Scholia
  35. Mao LM, Tang Q, Wang JQ; ''''; , PubMed Europe PMC Scholia
  36. Houddane A, Bultot L, Novellasdemunt L, Johanns M, Gueuning MA, Vertommen D, Coulie PG, Bartrons R, Hue L, Rider MH; ''Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes.''; Cell Signal, 2017 PubMed Europe PMC Scholia
  37. Zhang X, Tang N, Hadden TJ, Rishi AK; ''Akt, FoxO and regulation of apoptosis.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  38. Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y; ''''; , PubMed Europe PMC Scholia
  39. Fernandez-Marcos PJ, Nóbrega-Pereira S; ''NADPH: new oxygen for the ROS theory of aging.''; Oncotarget, 2016 PubMed Europe PMC Scholia
  40. Massart C, Hoste C, Virion A, Ruf J, Dumont JE, Van Sande J; ''Cell biology of H2O2 generation in the thyroid: investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines.''; Mol Cell Endocrinol, 2011 PubMed Europe PMC Scholia
  41. Oetting A, Yen PM; ''New insights into thyroid hormone action.''; Best Pract Res Clin Endocrinol Metab, 2007 PubMed Europe PMC Scholia
  42. Chen J, Bell J, Lau BT, Whittaker T, Stapleton D, Ji HP; ''A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer.''; Oncogenesis, 2019 PubMed Europe PMC Scholia
  43. Simonides WS, Mulcahey MA, Redout EM, Muller A, Zuidwijk MJ, Visser TJ, Wassen FW, Crescenzi A, da-Silva WS, Harney J, Engel FB, Obregon MJ, Larsen PR, Bianco AC, Huang SA; ''Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
  44. Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stöckli J, James DE; ''mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.''; Cell Rep, 2016 PubMed Europe PMC Scholia
  45. Aguayo-Mazzucato C, DiIenno A, Hollister-Lock J, Cahill C, Sharma A, Weir G, Colton C, Bonner-Weir S; ''MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC.''; J Clin Endocrinol Metab, 2015 PubMed Europe PMC Scholia
  46. Inoki K, Li Y, Zhu T, Wu J, Guan KL; ''TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.''; Nat Cell Biol, 2002 PubMed Europe PMC Scholia
  47. Rivolta CM, Targovnik HM; ''Molecular advances in thyroglobulin disorders.''; Clin Chim Acta, 2006 PubMed Europe PMC Scholia
  48. Song H, Smolen P, Av-Ron E, Baxter DA, Byrne JH; ''Bifurcation and singularity analysis of a molecular network for the induction of long-term memory.''; Biophys J, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135857view12:45, 19 November 2024EweitzModified description
135823view14:05, 12 November 2024EgonwFixed the ChEBI identifier of T4
128791view00:26, 22 February 2024EweitzOntology Term : 'thyroid follicular cell' added !
128790view00:25, 22 February 2024EweitzOntology Term : 'neuron' added !
128789view00:25, 22 February 2024EweitzOntology Term : 'glial cell' added !
128788view00:24, 22 February 2024EweitzStandardize case
127760view09:28, 3 December 2023EgonwChEBI id for Ca2+ instead of the "Ca" atom
123317view19:41, 15 July 2022EgonwMore metabolites typed as such
123315view11:34, 15 July 2022EgonwT4 is a metabolite
120402view09:12, 30 November 2021Fehrhartboxed pathway nodes
117846view15:16, 22 May 2021EweitzModified title
116407view09:04, 7 May 2021EweitzModified title
111628view06:17, 31 August 2020EgonwModified title
108781view13:57, 29 January 2020Rik-lahaije
108638view08:52, 14 January 2020Rik-lahaijechanged nodes
108396view20:35, 16 December 2019EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
108391view13:22, 16 December 2019Rik-lahaijelines
108390view13:13, 16 December 2019Rik-lahaijeModified description
108389view12:57, 16 December 2019Rik-lahaijeannotations
108388view12:52, 16 December 2019Rik-lahaijechanged legend
108387view12:46, 16 December 2019Rik-lahaije
108378view10:24, 15 December 2019Marvin M2Connected lines and converted some into graphical lines
108263view14:56, 3 December 2019L DupuisConverted interactions to graphical lines in legend
108262view14:55, 3 December 2019L DupuisConnected unconnected lines
108096view12:55, 28 November 2019FehrhartOntology Term : 'congenital hypothyroidism' added !
108095view12:52, 28 November 2019FehrhartOntology Term : 'disease pathway' added !
107964view09:26, 18 November 2019FehrhartOntology Term : 'thyroid-stimulating hormone signaling pathway' added !
107960view09:14, 14 November 2019Rik-lahaijeModified description
107959view09:09, 14 November 2019Rik-lahaijeModified title
107958view09:09, 14 November 2019Rik-lahaijeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACProteinA0A0K0K1K3 (Uniprot-TrEMBL)
ACTL6BGeneProductENSG00000077080 (Ensembl)
AGRPGeneProductENSG00000159723 (Ensembl)
AKTGeneProductENSG00000117020 (Ensembl)
ANPProteinA0A087X094 (Uniprot-TrEMBL)
AQP7GeneProductENSG00000165269 (Ensembl)
AS160GeneProductENSG00000136111 (Ensembl)
ASK1ProteinG3V4Q4 (Uniprot-TrEMBL)
ATF2GeneProductENSG00000115966 (Ensembl)
ATGLProteinQ96AD5 (Uniprot-TrEMBL)
Adenylate cyclaseProteinA0A0A0MSC1 (Uniprot-TrEMBL)
Albumin bound T3MetaboliteCHEBI:18258 (ChEBI)
Albumin bound T4MetaboliteCHEBI:75602 (ChEBI)
B-Catenin GeneProductENSG00000168036 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BNPProteinP16860 (Uniprot-TrEMBL)
Beta-3 ARProteinP13945 (Uniprot-TrEMBL)
CASP9GeneProductENSG00000132906 (Ensembl)
CREB GeneProductENSG00000107175 (Ensembl)
CREBGeneProductENSG00000107175 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cell cycle arrestPathwayWP3804 (WikiPathways)
Cell growth, proliferation and protein synthesisPathwayWP3318 (WikiPathways)
Cell survivalPathwayhsa04211 (KEGG Pathway)
DAGMetaboliteCHEBI:18035 (ChEBI)
DGMetaboliteCHEBI:18035 (ChEBI)
DIO1GeneProductENSG00000211452 (Ensembl)
DIO2GeneProductENSG00000211448 (Ensembl)
DIO3GeneProductENSG00000197406 (Ensembl)
DITMetaboliteCHEBI:23796 (ChEBI)
DUOX2GeneProductENSG00000140279 (Ensembl)
DUOXA2GeneProductENSG00000140274 (Ensembl)
ERKProteinP28482 (Uniprot-TrEMBL)
FFAMetaboliteCHEBI:35366 (ChEBI)
FGF21GeneProductENSG00000105550 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FRS2GeneProductENSG00000166225 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
Glucose metabolismPathwayWP661 (WikiPathways)
Glucose transportPathwayhsa04931 (KEGG Pathway)
GlycerolMetaboliteCHEBI:17754 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2O2MetaboliteCHEBI:16240 (ChEBI)
Hypothalamic AMPK MetaboliteCHEBI:85053 (ChEBI)
IP3MetaboliteCHEBI:16595 (ChEBI)
IP3RGeneProductENSG00000123104 (Ensembl)
ITGAGeneProductENSG00000138448 (Ensembl)
ITGBGeneProductENSG00000259207 (Ensembl)
IYDGeneProductENSG00000009765 (Ensembl)
InflammationPathwayWP453 (WikiPathways)
JMJD1BProteinQ7LBC6 (Uniprot-TrEMBL)
KDM1AGeneProductENSG00000004487 (Ensembl)
KLBGeneProductENSG00000134962 (Ensembl)
MAFAGeneProductENSG00000182759 (Ensembl)
MAPK signallingPathwayWP1403 (WikiPathways)
MC4RGeneProductENSG00000166603 (Ensembl)
MCT8ProteinP36021 (Uniprot-TrEMBL)
MDM2GeneProductENSG00000135679 (Ensembl)
MEKProteinQ02750 (Uniprot-TrEMBL)
MGMetaboliteCHEBI:17408 (ChEBI)
MGLLGeneProductENSG00000074416 (Ensembl)
MITMetaboliteCHEBI:25400 (ChEBI)
MKK3 ProteinA0A024R2W7 (Uniprot-TrEMBL)
MLST8GeneProductENSG00000167965 (Ensembl)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
NHSLGeneProductENSG00000135540 (Ensembl)
NOTCH signalingPathwaymap04330 (KEGG Pathway)
NOTCHGeneProductENSG00000148400 (Ensembl)
NP-RProteinP16066 (Uniprot-TrEMBL)
NPYGeneProductENSG00000122585 (Ensembl)
Na+MetaboliteCHEBI:29101 (ChEBI)
NorepinephrineMetaboliteCHEBI:33569 (ChEBI)
Oxidative phosphorylationPathwaymap00190 (KEGG Pathway)
P53GeneProductENSG00000141510 (Ensembl)
PAX8ProteinA0A140TA56 (Uniprot-TrEMBL)
PCG-1 GeneProductENSG00000109819 (Ensembl)
PFKFB2GeneProductENSG00000123836 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PKAProteinQ15136 (Uniprot-TrEMBL)
PKCProteinA0A087X0I9 (Uniprot-TrEMBL)
PKGProteinA0A140VJM3 (Uniprot-TrEMBL)
PLCProteinA0A087WT80 (Uniprot-TrEMBL)
PLINGeneProductENSG00000166819 (Ensembl)
POMCGeneProductENSG00000115138 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
PRAS40GeneProductENSG00000204673 (Ensembl)
PRDM16GeneProductENSG00000142611 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RAPTORGeneProductENSG00000141564 (Ensembl)
RASGeneProductENSG00000174775 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RPS6KA6GeneProductENSG00000072133 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RXRGeneProductENSG00000186350 (Ensembl)
RasGeneProductENSG00000174775 (Ensembl)
S6GeneProductENSG00000137154 (Ensembl)
SECISBP2LGeneProductENSG00000138593 (Ensembl)
SHHGeneProductENSG00000164690 (Ensembl)
SIRT6GeneProductENSG00000077463 (Ensembl)
SLC16A10GeneProductENSG00000112394 (Ensembl)
SLC26A4GeneProductENSG00000091137 (Ensembl)
SLC5A5GeneProductENSG00000105641 (Ensembl)
SLCO1C1GeneProductENSG00000139155 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
T2MetaboliteCHEBI:89575 (ChEBI)
T3MetaboliteCHEBI:18258 (ChEBI)
T4MetaboliteCHEBI:75602 (ChEBI)
TBG bound T3MetaboliteCHEBI:18258 (ChEBI)
TBG bound T4MetaboliteCHEBI:75602 (ChEBI)
TCA cycle Pathwaymap00020 (KEGG Pathway)
TG bound MIT and DITComplexE5RG33 (Uniprot-TrEMBL)
TG bound MIT, DIT, T3 and T4ComplexE5RG33 (Uniprot-TrEMBL)
TGMetaboliteCHEBI:17855 (ChEBI)
TGProteinE5RG33 (Uniprot-TrEMBL)
THRA1GeneProductENSG00000126351 (Ensembl)
THRB1GeneProductENSG00000151090 (Ensembl)
THRProteinP10827 (Uniprot-TrEMBL)
TPOProteinE9PFM6 (Uniprot-TrEMBL)
TRHGeneProductENSG00000170893 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TSHGeneProductENSG00000134200 (Ensembl)
TSHRGeneProductENSG00000165409 (Ensembl)
TTF1GeneProductENSG00000125482 (Ensembl)
TTF2GeneProductENSG00000116830 (Ensembl)
TTR bound T3MetaboliteCHEBI:18258 (ChEBI)
TTR bound T4MetaboliteCHEBI:75602 (ChEBI)
UCP1GeneProductENSG00000109424 (Ensembl)
Wnt signalingPathwaymap04310 (KEGG Pathway)
WntGeneProductENSG00000162552 (Ensembl)
ZNF516GeneProductENSG00000101493 (Ensembl)
cAMPMetaboliteCHEBI:17489 (ChEBI)
cGMPMetaboliteCHEBI:16356 (ChEBI)
iodideMetaboliteCHEBI:16382 (ChEBI)
mTOR PathwayWP3318 (WikiPathways) MTORC1
mTORGeneProductENSG00000198793 (Ensembl)
mTORPathwaymap04150 (KEGG Pathway)
oxygenMetaboliteCHEBI:25805 (ChEBI)
p38ProteinQ16539 (Uniprot-TrEMBL)
tRNAsecMetaboliteCHEBI:29264 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4746"
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