GLP-1 in pancreatic islet cells (Homo sapiens)

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1Pancreatic islet?Alpha cellBeta cellGlucoseGLP-1InsulinGLP1RGCGIL6IL6RSLC2A1SLC2A2INSGlucoseMetabolic stressSystematic inflammationExerciseHyperglycemiaObesityDiabetesProliferation


Description

Factors in GLP-1 production in pancreatic alpha cells, and the hypothetical function of resulting GLP-1 in pancreatic beta cells. Glucagon-like peptide-1 (GLP-1) is a short protein that suppresses feeding and helps manage glucose levels in diabetes. It is encoded by the GCG gene. Based on Figure 3 in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190119.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Davis EM, Sandoval DA; ''Glucagon-like peptide-1: Actions and influence on pancreatic hormone function''; Comprehensive Physiology, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129190view10:04, 15 March 2024EgonwUpdated the Wikidata identifiers
129165view22:03, 13 March 2024EweitzMore beta interiorly
129162view12:00, 13 March 2024EweitzEconomize layout
129157view02:26, 13 March 2024EweitzModified description
129156view02:24, 13 March 2024EweitzAdd literature reference
129155view02:15, 13 March 2024EweitzIdentify remaining nodes
129154view01:59, 13 March 2024EweitzSoften inset frames
129153view01:54, 13 March 2024EweitzEconomize layout
129152view01:46, 13 March 2024EweitzPolish graphics
129151view01:24, 13 March 2024EweitzUpgrade process and disease nodes
129150view01:08, 13 March 2024EweitzOntology Term : 'type B pancreatic cell' added !
129149view01:08, 13 March 2024EweitzOntology Term : 'insulin secreting cell' added !
129148view01:07, 13 March 2024EweitzOntology Term : 'CL:0000169' removed !
129147view01:07, 13 March 2024EweitzOntology Term : 'facilitative sugar transporter mediated glucose transport pathway' added !
129146view01:04, 13 March 2024EweitzOntology Term : 'insulin secretion pathway' added !
129145view01:03, 13 March 2024EweitzOntology Term : 'signaling pathway' added !
129144view01:02, 13 March 2024EweitzOntology Term : 'type B pancreatic cell' added !
129143view01:02, 13 March 2024EweitzOntology Term : 'pancreatic A cell' added !
129142view01:01, 13 March 2024EweitzOntology Term : 'glucagon-like peptide-1 biosynthetic pathway' added !
129141view23:45, 12 March 2024EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Diabeteshttps://www.wikidata.org/wiki/Q12206 (Wikidata)
Exercisehttps://www.wikidata.org/wiki/Q219067 (Wikidata)
GCGGeneProductENSG00000115263 (Ensembl)
GLP-1Proteinhttps://www.wikidata.org/wiki/Q424611 (Other)
GLP1RGeneProductENSG00000112164 (Ensembl)
GlucoseMetabolite17234 (ChEBI)
Hyperglycemiahttps://www.wikidata.org/wiki/Q271993 (Wikidata)
IL6GeneProductENSG00000136244 (Ensembl)
IL6RGeneProductENSG00000160712 (Ensembl)
INSGeneProductENSG00000254647 (Ensembl)
InsulinProteinP01308 (Uniprot-TrEMBL)
Metabolic stresshttp://purl.jp/bio/4/id/200906012910470412 (Other)
Obesityhttps://www.wikidata.org/wiki/Q12174 (Wikidata)
Proliferationhttps://www.wikidata.org/wiki/Q189101 (Wikidata)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC2A2GeneProductENSG00000163581 (Ensembl)
Systematic inflammationhttps://www.wikidata.org/wiki/Q7663815 (Wikidata)

Annotated Interactions

No annotated interactions

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