Lysine biosynthesis (Saccharomyces cerevisiae)

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1, 2LYS1diphosphateL-glutamateNAD+Coenzyme AL-lysineLYS12L-2-aminoadipyl-[LYS2 L-2-aminoadipyl-carrier-protein]NADP+NADHL-SaccharopineLYS21H+LYS20NADHL-2-aminoadipatecis-homoaconitate2-oxoglutarate(1R,2S)-homoisocitrateNADPHCO2LYS2ATPL-glutamateacetyl-CoA(S)-2-amino-6-oxohexanoate 2-oxoglutarateLYS4LYS9ARO82-oxoadipateHomocitrateH2OAMPH2OH2OH2OH2OH+2-oxoglutarateNAD+H+NADPHH+NADP+


Description

S. cerevisiae synthesizes the essential amino acid L-lysine via the L-alpha-aminoadipic acid pathway instead of the diaminopmelate pathway (CITS: [10714900]). Originally proposed to be characteristic of fungi, recent studies suggest prokaryotes also synthesize lysine via the alpha-aminoadipic acid pathway (CITS: [11029074]). Intermediates in this pathway are often incorporated into secondary metabolites. For example, it has been well- studied that alpha-aminoadipate is required for penicillin production (CITS: [10714900]). Regulation of the lysine biosynthetic pathway in S. cerevisiae is an interaction between general amino acid control (via Gcn4p) (CITS: [Hinnebusch]), feedback inhibition of homocitrate synthase activity by lysine (CITS: [10103047]), and induction of Lys14p by alpha-aminoadipate semialdehyde (CITS: [10975256]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

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Quality Tags

Ontology Terms

 

Bibliography

  1. ''L-lysine biosynthesis IV''; https://biocyc.org/pathway?orgid=META&id=LYSINE-AMINOAD-PWY,
  2. Zabriskie TM, Jackson MD; ''Lysine biosynthesis and metabolism in fungi.''; Nat Prod Rep, 2000 PubMed Europe PMC Scholia
  3. Nishida H, Nishiyama M; ''What is characteristic of fungal lysine synthesis through the alpha-aminoadipate pathway?''; J Mol Evol, 2000 PubMed Europe PMC Scholia
  4. Feller A, Ramos F, Piérard A, Dubois E; ''In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p.''; Eur J Biochem, 1999 PubMed Europe PMC Scholia
  5. El Alami M, Feller A, Piérard A, Dubois E; ''Characterisation of a tripartite nuclear localisation sequence in the regulatory protein Lys14 of Saccharomyces cerevisiae.''; Curr Genet, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135187view13:37, 7 August 2024EgonwAdded references from the description to the formal reference list
135186view13:33, 7 August 2024EgonwAnother URL citation
130617view04:42, 29 May 2024KhanspersOntology Term : 'classic metabolic pathway' added !
130616view04:41, 29 May 2024Khanspersoverhaul: updated interactions, xrefs, enzymes, layout
117310view11:18, 20 May 2021EweitzModified title
89692view10:11, 26 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
69940view20:14, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69660view20:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
67437view11:01, 26 June 2013DdiglesOntology Term : 'lysine biosynthetic pathway' added !
41900view04:53, 2 March 2011MaintBotRemoved redundant pathway information and comments
36626view22:33, 9 April 2010MaintBotDescription and bibliography added from SGD
21800view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Lysine Biosynthesis]] moved to [[Pathway:WP533]]: Moved to stable identifier
12774view08:02, 17 May 2008MaintBotautomated metabolite conversion
8822view14:09, 7 January 2008MaintBotAdded to category $category
8820view14:09, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(1R,2S)-homoisocitrateMetabolite15404 (ChEBI)
(S)-2-amino-6-oxohexanoate MetaboliteHMDB59595 (HMDB)
2-oxoadipateMetaboliteHMDB00225 (HMDB)
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
AMPMetaboliteHMDB00045 (HMDB)
ARO8GeneProductYGL202W (Ensembl)
ATPMetaboliteHMDB00538 (HMDB)
CO2MetaboliteCHEBI:16526 (ChEBI)
Coenzyme AMetabolite64885-97-8 (CAS)
H+MetaboliteHMDB59597 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
HomocitrateMetaboliteCHEBI:36457 (ChEBI)
L-2-aminoadipateMetaboliteHMDB00510 (HMDB)
L-2-aminoadipyl-[LYS2 L-2-aminoadipyl-carrier-protein]Metabolite
L-SaccharopineMetaboliteCHEBI:16927 (ChEBI)
L-glutamateMetabolite56-86-0 (CAS)
L-lysineMetabolite56-87-1 (CAS)
LYS12GeneProductS000001356 (SGD)
LYS1GeneProductS000001473 (SGD)
LYS20GeneProductS000002341 (SGD)
LYS21GeneProductS000002289 (SGD)
LYS2GeneProductS000000319 (SGD)
LYS4GeneProductS000002642 (SGD)
LYS9GeneProductS000005333 (SGD)
NAD+MetaboliteHMDB00902 (HMDB)
NADHMetabolite53-84-9 (CAS)
NADP+MetaboliteHMDB00217 (HMDB)
NADPHMetabolite53-57-6 (CAS)
acetyl-CoAMetabolite72-89-9 (CAS)
cis-homoaconitateMetaboliteHMDB60320 (HMDB)
diphosphateMetaboliteHMDB00250 (HMDB)

Annotated Interactions

No annotated interactions
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