Sulfate assimilation pathway (Saccharomyces cerevisiae)

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Revision as of 23:16, 22 October 2024 by Khanspers (Talk | contribs)
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Description

In yeast, the sulfate assimilation pathway consists of sulfates uptake via Sul1p and Sul2p, activation to adenylate compounds, reduction to sulfide, and subsequent incorporation into carbon chains. The importance of activating sulfate to adenylyl sulfate (APS) and phosphoadenylyl sulfate (PAPS) stems from the fact that physiological reducing agents (e.g. NADPH, NADH) are not large enough in E0' to reduce sulfate directly. Adenylation lowers sulfate's electropotential, enabling cells to circumvent what would otherwise be an endergonic reaction. After its conversion to PAPS, sulfate is reduced to sulfite by PAPS reductase (Met16p) and again to sulfide by sulfite reductase (Met5p and Met10p). The subsequent incorporation of sulfide into a carbon chain varies by organism; in S. cerevisiae, sulfide can react with O-acetylhomoserine via Met17p to form homocysteine, the major intermediate in the biosynthesis and interconversion of methionine and cysteine. Source: https://pathway.yeastgenome.org/

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

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Quality Tags

Ontology Terms

 

Bibliography

  1. ''sulfate assimilation pathway ''; YeastPathways,

History

View all...
CompareRevisionActionTimeUserComment
135683view23:16, 22 October 2024KhanspersOntology Term : 'classic metabolic pathway' added !
135682view23:16, 22 October 2024Khanspersremoved GenMAPP comments
135681view23:15, 22 October 2024KhanspersModified description
135680view23:14, 22 October 2024Khanspersupdated reference
135679view23:14, 22 October 2024KhanspersModified title
135678view23:14, 22 October 2024Khanspersadd reference
89709view08:29, 27 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
70251view21:37, 15 July 2013MaintBotupdated to 2013 schema
70045view05:55, 12 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67665view11:46, 26 June 2013DdiglesOntology Term : 'sulfate assimilation pathway' added !
46440view01:49, 28 January 2012Khanspersremoved problematic characters in labels
41794view04:48, 2 March 2011MaintBotRemoved redundant pathway information and comments
21901view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Sulfate Assimilation Pathway II]] moved to [[Pathway:WP579]]: Moved to stable identifier
12853view08:05, 17 May 2008MaintBotautomated metabolite conversion
8936view14:12, 7 January 2008MaintBotAdded to category $category
8934view14:12, 7 January 2008J.HeckmanUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3'-phosphoadenylyl-sulfateMetabolite58339 (ChEBI)
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
H+Metabolite15378 (ChEBI)
H2OMetabolite15377 (ChEBI)
L-homocysteine biosynthesisPathway
MET10GeneProductS000001926 (SGD)
MET14GeneProductS000001484 (SGD)
MET16GeneProductS000006371 (SGD)
MET3GeneProductS000003771 (SGD)
MET5GeneProductS000003898 (SGD)
NADP+Metabolite58349 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
adenosine 3'5'-bisphosphateMetabolite3805-37-6 (CAS)
adenosine 5'-phosphosulfateMetabolite58243 (ChEBI)
diphosphateMetabolite29888 (ChEBI)
hydrogen sulfideMetabolite16136 (ChEBI)
sulfateMetabolite16189 (ChEBI)
sulfiteMetabolite17359 (ChEBI)

Annotated Interactions

No annotated interactions
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