Inhibition of Gαq-regulated signaling in uveal melanoma (Homo sapiens)

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Description

This pathway describes parallel and converging signaling pathways driven by Gαq (GNAQ) in Uveal Melanoma, and the inhibitory effects of Darovasertib and FAKi (FAK inhibitor). Key points from Arang et al: Darovasertib is a dual inhibitor of PKC and PRK/PKN; downstream of mutant Gαq darovasertib blocks ERK and diminishes FAK activity; Darovasertib and FAKi act synergistically in preclinical uveal melanoma models. This pathway model was developed based on Figure 7 in Arang et al.

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Ontology Terms

 

Bibliography

  1. Arang N, Lubrano S, Ceribelli M, Rigiracciolo DC, Saddawi-Konefka R, Faraji F, Ramirez SI, Kim D, Tosto FA, Stevenson E, Zhou Y, Wang Z, Bogomolovas J, Molinolo AA, Swaney DL, Krogan NJ, Yang J, Coma S, Pachter JA, Aplin AE, Alessi DR, Thomas CJ, Gutkind JS; ''High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma.''; Cell Rep Med, 2023 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135838view01:37, 16 November 2024KhanspersPKC EC number
135837view01:32, 16 November 2024KhanspersEconomize layout
135836view00:48, 16 November 2024KhanspersPI3K and AKT/mtor
135419view17:47, 5 September 2024Khansperstest
135356view22:28, 27 August 2024KhanspersModified description
135355view22:10, 27 August 2024Khanspersadded mutation and legend
135354view21:51, 27 August 2024KhanspersOntology Term : 'melanocyte' added !
135349view21:38, 27 August 2024KhanspersModified description
135348view21:27, 27 August 2024KhanspersOntology Term : 'G protein mediated signaling pathway' added !
135347view21:27, 27 August 2024KhanspersOntology Term : 'uveal cancer' added !
135346view21:25, 27 August 2024KhanspersModified title
135345view21:23, 27 August 2024KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
DAGMetaboliteCHEBI:18035 (ChEBI)
DarovasertibMetabolite
FAK inhibitorMetaboliteCHEBI:76617 (ChEBI)
FAKGeneProductPTK2 (HGNC)
G-betaGeneProductIPR016346 (InterPro)
G-gammaGeneProductIPR036284 (InterPro)
GNAQGeneProductGNAQ (HGNC)
LATS1GeneProductLATS1 (HGNC)
LATS2GeneProductLATS2 (HGNC)
MAPK1GeneProductMAPK1 (HGNC)
MOB1AGeneProductMOB1A (HGNC)
MTORGeneProduct2475 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PKCGeneProduct
PKN1GeneProductPKN1 (HGNC)
PKN2GeneProductPKN2 (HGNC)
PKN3GeneProductPKN3 (HGNC)
PLCB1GeneProductPLCB1 (HGNC)
PLCB2GeneProductPLCB2 (HGNC)
PLCB3GeneProductPLCB3 (HGNC)
PLCB4GeneProductPLCB4 (HGNC)
RHOAGeneProductRHOA (HGNC)
ROCK1GeneProductROCK1 (HGNC)
TEAD1GeneProductTEAD1 (HGNC)
TEAD2GeneProductTEAD2 (HGNC)
TEAD3GeneProductTEAD3 (HGNC)
TEAD4GeneProductTEAD4 (HGNC)
TRIOGeneProductTRIO (HGNC)
TSC1GeneProduct7248 (Entrez Gene)
TSC2GeneProduct7249 (Entrez Gene)
YAP1GeneProductYAP1 (HGNC)

Annotated Interactions

No annotated interactions

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