Glycine metabolism (Homo sapiens)

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Description

Glycine is degraded through three pathways: The glycine cleavage system (GCS); by serine hydroxymethyltransferase, and conversion to glyoxylate. In animals, the main pathway is GCS, which is essentially the reverse of the glycine synthase pathway.

Degradation of by serine hydroxymethyltransferase happens in two steps. First, glycine is converted to serine by serine hydroxymethyl transferase. Serine is then converted to pyruvate by serine dehydratase. Glycine can also be converted to glyoxylate by D-amino acid oxidase. Glyoxylate is then oxidized by hepatic lactate dehydrogenase to oxalate.

Description adapted from [Wikipedia](https://en.wikipedia.org/wiki/Glycine#Metabolism).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hall JC; ''Glycine.''; JPEN J Parenter Enteral Nutr, 1998 PubMed Europe PMC Scholia
  2. Wang W, Wu Z, Dai Z, Yang Y, Wang J, Wu G; ''Glycine metabolism in animals and humans: implications for nutrition and health.''; Amino Acids, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139879view17:43, 9 July 2025Khanspersadded lit ref
139878view17:41, 9 July 2025KhanspersModified description
139663view07:08, 28 June 2025EgonwMore unicode
138124view07:20, 16 March 2025EgonwAdded a reference
138123view07:16, 16 March 2025EgonwMore identifiers
138046view06:23, 13 March 2025EgonwConverted labels to data nodes
137537view19:24, 3 March 2025KhanspersModified description
126384view10:07, 26 April 2023EgonwLicense is CCZero
117738view12:41, 22 May 2021EweitzModified title
108231view14:14, 30 November 2019EgonwBetter ChEBI identifier.
106693view13:04, 17 September 2019MaintBotHMDB identifier normalization
96064view17:56, 15 February 2018KhanspersModified description
94187view14:06, 25 August 2017Mkutmonadded missing identifier
85086view22:54, 12 April 2016EgonwAdded a few metabolite identifiers.
82220view02:46, 16 September 2015AlexanderPicofixed reaction model for biopax conversion
70639view10:07, 20 August 2013EgonwAdded a ChEBI id for 'Purines'.
70637view10:01, 20 August 2013EgonwConverted a IUPAC-named Label into a Chemspider-backed Metabolite DataNode.
63200view20:54, 8 May 2013MaintBotUpdating gpml version
62369view00:37, 28 April 2013AlexanderPicoFixed annotations and biochemistry
45321view20:10, 7 October 2011AlexanderPicoOntology Term : 'glycine metabolic pathway' added !
41169view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38926view21:31, 24 September 2010AlexanderPicoconnected DAO
38924view21:29, 24 September 2010AlexanderPicooverhaul
37213view20:52, 21 May 2010KhanspersModified categories
36309view14:02, 18 March 2010Essam SharafPeriodical save, work in progress
36306view13:52, 18 March 2010Essam SharafPeriodical save, work in progress
36305view13:42, 18 March 2010Essam SharafPeriodical save, work in progress
36304view13:41, 18 March 2010Essam SharafNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Bile SaltsMetaboliteCHEBI:36277 (ChEBI)
CreatineMetabolite586 (PubChem-compound)
FADMetabolite
FADH2Metabolite
GlutamateMetabolite4302384 (Chemspider)
GlutathioneMetabolite124886 (PubChem-compound)
Glycine OxidaseGeneProduct1.4.3.19 (Enzyme Nomenclature)
Glycine TransaminaseGeneProduct2.6.1.4 (Enzyme Nomenclature)
GlycineMetaboliteHMDB0000123 (HMDB)
GlyoxalateMetabolite760 (PubChem-compound)
HemeMetaboliteCHEBI:30413 (ChEBI)
H₂OMetabolite15377 (ChEBI)
H₂O₂Metabolite16240 (ChEBI)
MTHFMetabolite97272 (Chemspider)
MTHFRGeneProductENSG00000177000 (Ensembl)
NH3Metabolite
OxalateMetabolite971 (PubChem-compound)
O₂Metabolite15379 (ChEBI)
PurinesMetaboliteCHEBI:26401 (ChEBI)
PyruvateMetabolite96901 (Chemspider)
SHMT1GeneProduct6470 (Entrez Gene)
SHMT2GeneProduct6472 (Entrez Gene)
SerineMetabolite17115 (ChEBI)
a-IminoacetateMetaboliteCHEBI:53664 (ChEBI)
a-KetoglutarateMetabolite

Annotated Interactions

No annotated interactions

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