Notch signaling pathway (Mus musculus)

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S3MAPK signaling pathwayNotch Intracellular DomainNICDgene expressionDNARas/Mapco-repressor complexS2RBP-JDLL1APH1ADTX3NOTCH4DTX2CIRDVL2MAML1MAML3HDAC1GCN5L2JAG1JAG2DTX1SKIPDVL1PSEN1PCAFCTBP1RBPSUHLNCOR2DLL4MFNGLOC330129PSEN2CTBP2NOTCH1HES1LFNGNUMBDVL3NOTCH3PTCRANUMBLCREBBPNOTCH2DTX4RFNGHES5NCSTNTNFDLL3ADAM17HDAC2APH1BDTX31


Description

No description

Comments

GenMAPP notes 
http://www.genome.jp/kegg/pathway/hsa/hsa04330.html
GenMAPP remarks 
Adapted from KEGG (right click for notes)

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Quality Tags

Ontology Terms

 

Bibliography

  1. Weinmaster G; ''The ins and outs of notch signaling.''; Mol Cell Neurosci, 1997 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127988view23:06, 20 January 2024EweitzStandardize node and identify pathway; standardize case
122790view00:43, 18 May 2022AlexanderPicocleaning up broken comments
117922view10:36, 23 May 2021EweitzModified title
104994view04:24, 28 June 2019KhanspersModified description
79679view12:38, 4 April 2015EgonwThe 'LOC330129' identifier is not found in BridgeDb and not in Entrez.
78440view10:26, 7 January 2015MaintBotadded missing graphIds
74445view07:33, 20 April 2014EgonwAdded the PubMed 9245493 from scratch, hoping it will now show up in the publist properly.
74444view07:30, 20 April 2014EgonwFixed a PubMed ID.
71312view17:14, 17 October 2013MaintBotAutomated update of data sources
69810view14:29, 11 July 2013Mkutmonfixing unconnected lines
69070view18:08, 8 July 2013MaintBotUpdated to 2013 gpml schema
67524view11:20, 26 June 2013DdiglesOntology Term : 'Notch signaling pathway' added !
41252view00:20, 2 March 2011MaintBotRemoved redundant pathway information and comments
40101view11:08, 8 February 2011Thomasfixed several gene annotations
35611view15:58, 12 February 2010Thomasconnected lines
35610view15:56, 12 February 2010Thomasadded literature
35609view15:56, 12 February 2010ThomasModified description
33382view14:39, 30 November 2009MaintBotRemoved group label
32984view00:06, 30 September 2009MaintBotadded xrefs and connectors
32983view23:59, 29 September 2009MaintBotPeriodical save, work in progress
29892view11:18, 9 June 2009Thomasupdated ensembl references
20739view11:29, 14 November 2008MaintBot[[Pathway:Mus musculus:Notch signaling KEGG]] moved to [[Pathway:WP29]]: Moved to stable identifier
8280view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Notch signaling KEGG]] moved to [[Pathway:Mus musculus:Notch signaling KEGG]]: Renaming species
7760view16:16, 18 December 2007MaintBotfixed category names
7281view12:41, 4 November 2007MaintBotAdded categories to GPML
6478view22:19, 22 May 2007169.230.77.174gpml file for [[Mouse:Notch_signaling_KEGG]]

External references

DataNodes

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NameTypeDatabase referenceComment
ADAM17GeneProductADAM17 (Entrez Gene)
APH1AGeneProductAPH1A (Entrez Gene)
APH1BGeneProductAPH1B (Entrez Gene)
CIRGeneProduct1700023B02RIK (Entrez Gene)
CREBBPGeneProductCREBBP (Ensembl Mouse)
CTBP1GeneProductCTBP1 (Ensembl Mouse)
CTBP2GeneProductCTBP2 (Ensembl Mouse)
DLL1GeneProductDLL1 (Entrez Gene)
DLL3GeneProductDLL3 (Entrez Gene)
DLL4GeneProductDLL4 (Entrez Gene)
DTX1GeneProductDTX1 (Ensembl Mouse)
DTX2GeneProductDTX2 (Ensembl Mouse)
DTX31GeneProduct209200 (Entrez Gene)
DTX3GeneProductDTX3 (Ensembl Mouse)
DTX4GeneProductDTX4 (Ensembl Mouse)
DVL1GeneProductDVL1 (Ensembl Mouse)
DVL2GeneProductDVL2 (Ensembl Mouse)
DVL3GeneProductDVL3 (Ensembl Mouse)
GCN5L2GeneProductGCN5L2 (Ensembl Mouse)
HDAC1GeneProduct433759 (Entrez Gene)
HDAC2GeneProductHDAC2 (Ensembl Mouse)
HES1GeneProductHES1 (Entrez Gene)
HES5GeneProductHES5 (Entrez Gene)
JAG1GeneProductJAG1 (Ensembl Mouse)
JAG2GeneProductJAG2 (Ensembl Mouse)
LFNGGeneProductLFNG (Ensembl Mouse)
LOC330129GeneProductLOC330129 (Entrez Gene)
MAML1GeneProductMAML1 (Ensembl Mouse)
MAML3GeneProduct433586 (Entrez Gene)
MFNGGeneProductMFNG (Ensembl Mouse)
NCOR2GeneProductNCOR2 (Entrez Gene)
NCSTNGeneProductNCSTN (Entrez Gene)
NOTCH1GeneProductNOTCH1 (Entrez Gene)
NOTCH2GeneProductNOTCH2 (Entrez Gene)
NOTCH3GeneProductNOTCH3 (Entrez Gene)
NOTCH4GeneProductNOTCH4 (Entrez Gene)
NUMBLGeneProduct18223 (Entrez Gene)
NUMBGeneProductNUMB (Ensembl Mouse)
PCAFGeneProductPCAF (Entrez Gene)
PSEN1GeneProductPSEN1 (Ensembl Mouse)
PSEN2GeneProductPSEN2 (Ensembl Mouse)
PTCRAGeneProductPTCRA (Entrez Gene)
RBP-JGeneProductRBPSUH (Entrez Gene) aka RBP-Jkappa aka CBF1. Serves as a co-factor for the processed notch receptor after translocation to the nucleus to activate down-stream notch transcription. PMID: 15187023. In the nucleus, NIC (processed notch) regulates transcription through association with the DNA-binding protein RBP-J (also known as CBF1, KBF2, or CSL). The primary gene targets of RBP-J include members of the hairy and enhancer of split (HES) and hairy related transcription factor (HRT) families of basic-helix-loop-helix transcriptional repressors. In the absence of NIC, RBP-J actively represses transcription by way of recruitment of a corepressor complex.8 Nuclear translocation of NIC leads to dissociation of repressor proteins from RBP-J and formation of a coactivator complex.9-13. PMID: 15194757. RBP-J is a downstream target of the Notch pathway, a conserved signal transduction pathway that is important in development and cell fate determination (43). The intracellular domain (ICD) of activated Notch is released from the membrane through proteolytic cleavage and is translocated to the nucleus, where it is directed to target promoters through interaction with RBP-J (47, 68). RBP-J is a repressor in the ground state; its interaction with Notch ICD relieves this repression and turns on target genes. Interestingly, KSHV is not the only virus that has parasitized this pathway. Several viral transcription factors, e.g., EBNA2 and EBNA3 of Epstein-Barr virus and the 13S isoform of adenovirus E1A, are known to bind and activate target genes via RBP-J interactions (1, 22, 25, 26, 29). In all cases, the viral proteins target the same (central repressive) domain of RBP-J that is targeted by Notch, although KSHV RTA is capable of interactions with an additional region of RBP-J in vitro (33). RBP-J can bind RTA and recruit it to its cognate recognition site; when this happens, the activation function of RTA can relieve RBP-J-mediated repression and upregulate expression of the targeted gene. EMSA studies reveal that both sites A and C can bind to RBP-J; sequence inspection reveals that site A is a novel functional variant of known RBP-J recognition sites.
RBPSUHLGeneProductRBPSUHL (Entrez Gene)
RFNGGeneProductRFNG (Ensembl Mouse)
SKIPGeneProduct66354 (Entrez Gene)
TNFGeneProductTNF (Ensembl Mouse)

Annotated Interactions

No annotated interactions
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