DNA replication (Gallus gallus)

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DNA polymerase alpha:
primase: origin complexMcm10Cdc6Ubiquitinated Cdc6Orc complexCdt1Orc52. Activation of the pre-replicative complexMcm5Cdc6Cdc6Mcm2Mcm3Mcm2Mcm10Orc2Degraded by proteasome in cytosolRFC Heteropentamer:
RNA primer-DNA primerCdt1Orc complexProcessive complexOrc4Pre-replicative complexOrc complexMcm3Phosphorylated Orc14. Switching of origins to post-replicative stateUbiquitinDNA polymerase alpha:
primase: origin complexPhosphorylated Cdc6Orc2Orc3Cdt1p180UbiquitinOrc3RFC40GemininCdt1Orc3Mcm6Pre-replicative complexOrc3Mcm41. Assembly of the pre-replicative complexUbiquitinated Orc1RFC Heteropentamer:
RNA primer-DNA primer
PCNA homotrimerOrc5Orc4Mcm7p58RNA primer-DNA primer:
origin duplex:PCNARFC140Cdc6Cdt1RFC37RFC385. Leading/lagging strand synthesisMcm7Orc complexOrc1RNA primer-DNA primerOrc complexDNA
Polymerase AMcm 4,6,7 trimer forms and
associates with the replication forkRFC36RNA PrimerOrc2Orc5Primasep49Degraded by
proteasome
in cytosol3. DNA replication initiationPhosphorylation of
Mcm 2-7 complexRNA primer-DNA primerOriginp70Mcm6Orc2Mcm4Mcm5CDT1PCNARPA4MCM2MCM7POLD2RCJMB04_6d17dCTPUTPGTPPOLD1dGTPMCM10ORC2LPOLE2ORC5LMCM3ATPRFC1dATPCTPMCM5UBA52ORC3LRFC4ADPMCM4RPA1ATPORC4LRFC5ORC6LCDC45LATPDBF4CDC6POLD3dUTPCDK2ADPRFC2POLEGMNNUBCPRIM1PRIM2ATPPOLA2MCM6RPA3CDC7POLA1ORC1LRFC3POLD4


Description

No description

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 54% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117195view10:32, 18 May 2021EweitzModified title
68859view17:20, 8 July 2013MaintBotUpdated to 2013 gpml schema
68762view15:29, 7 July 2013EgonwRemoved data source where no ID was given.
67165view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40997view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
35218view15:49, 11 February 2010Thomasadded literature
35210view15:44, 11 February 2010ThomasModified description
35204view15:41, 11 February 2010ThomasModified description
33918view18:06, 9 December 2009MaintBotAutomatic update of empty xrefs
33442view14:58, 30 November 2009MaintBotRemoved group label
31499view21:32, 13 August 2009MaintBotFixed text labels
30326view20:45, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPGeneProduct
ATPGeneProduct
CDC45LGeneProduct416776 (Entrez Gene)
CDC6GeneProduct
CDC7GeneProduct424507 (Entrez Gene)
CDK2GeneProduct
CDT1GeneProduct
CTPGeneProduct
DBF4GeneProduct420536 (Entrez Gene)
GMNNGeneProduct421004 (Entrez Gene)
GTPGeneProduct
MCM10GeneProduct
MCM2GeneProduct416027 (Entrez Gene)
MCM3GeneProduct422043 (Entrez Gene)
MCM4GeneProduct426764 (Entrez Gene)
MCM5GeneProduct418058 (Entrez Gene)
MCM6GeneProduct424295 (Entrez Gene)
MCM7GeneProduct
ORC1LGeneProduct424640 (Entrez Gene)
ORC2LGeneProduct424077 (Entrez Gene)
ORC3LGeneProduct421822 (Entrez Gene)
ORC4LGeneProduct424307 (Entrez Gene)
ORC5LGeneProduct417714 (Entrez Gene)
ORC6LGeneProduct415749 (Entrez Gene)
PCNAGeneProduct373984 (Entrez Gene)
POLA1GeneProduct418593 (Entrez Gene)
POLA2GeneProduct
POLD1GeneProduct
POLD2GeneProduct
POLD3GeneProduct419053 (Entrez Gene)
POLD4GeneProduct
POLE2GeneProduct423567 (Entrez Gene)
POLEGeneProduct416997 (Entrez Gene)
PRIM1GeneProduct426646 (Entrez Gene)
PRIM2GeneProduct421878 (Entrez Gene)
RCJMB04_6d17GeneProduct419566 (Entrez Gene)
RFC1GeneProduct422788 (Entrez Gene)
RFC2GeneProduct396542 (Entrez Gene)
RFC3GeneProduct418907 (Entrez Gene)
RFC4GeneProduct424958 (Entrez Gene)
RFC5GeneProduct
RPA1GeneProduct417563 (Entrez Gene)
RPA3GeneProduct420578 (Entrez Gene)
RPA4GeneProduct
UBA52GeneProduct
UBCGeneProduct396425 (Entrez Gene)
UTPGeneProduct
dATPGeneProduct
dCTPGeneProduct
dGTPGeneProduct
dUTPGeneProduct

Annotated Interactions

No annotated interactions
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