Transcriptional activation by NRF2 in response to phytochemicals (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Niture SK, Khatri R, Jaiswal AK; ''Regulation of Nrf2-an update.''; Free Radic Biol Med, 2014 PubMed Europe PMC Scholia
2. Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
3. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...

Compare	Revision	Action	Time	User	Comment
	139059	view	04:38, 17 May 2025	Khanspers	increase font size, update layout
	137060	view	23:45, 26 February 2025	Khanspers	Modified description
	127273	view	00:02, 1 September 2023	Khanspers	updated phosphosite
	127249	view	17:35, 28 August 2023	Khanspers	added literature reference and updated description
	127189	view	22:12, 9 August 2023	Khanspers	updated phosphosites
	126220	view	15:05, 16 April 2023	Egonw	License is CCZero
	120028	view	22:58, 15 October 2021	Khanspers	updated phospho sites
	116707	view	09:35, 11 May 2021	Eweitz	Modified title
	106155	view	12:05, 16 August 2019	MaintBot	HMDB identifier normalization
	98703	view	18:19, 28 September 2018	Khanspers	Modified title
	94689	view	22:49, 4 October 2017	Khanspers	Modified description
	94688	view	22:49, 4 October 2017	Khanspers	Modified description
	94687	view	22:49, 4 October 2017	Khanspers	Modified description
	92783	view	21:24, 5 July 2017	AlexanderPico	Updated overall layout and state positions
	92717	view	19:41, 29 June 2017	Khanspers	minor layout change
	92716	view	19:40, 29 June 2017	Khanspers	corrected misplaced state
	92714	view	19:35, 29 June 2017	Khanspers	overhaul and update states
	79527	view	10:22, 24 March 2015	Zari	added ID for GSTA2
	74850	view	02:48, 1 May 2014	Nsalomonis	Added SLC7A11
	73388	view	16:42, 25 January 2014	Egonw	Added another missing metabolite identifier.
	73387	view	16:39, 25 January 2014	Egonw	Added a missing metabolite identifier.
	68891	view	17:28, 8 July 2013	MaintBot	Updated to 2013 gpml schema
	67421	view	10:59, 26 June 2013	Ddigles	Ontology Term : 'nuclear factor, erythroid derived 2, like 2 signaling pathway' added !
	66318	view	17:34, 17 June 2013	MaintBot	Modified title
	48217	view	05:28, 17 May 2012	MaintBot	Automatic update of PubChem xrefs
	46085	view	02:20, 15 December 2011	AllanKuchinsky	updated HGNC IDs
	44881	view	10:08, 6 October 2011	MartijnVanIersel	Ontology Term : 'oxidative stress response pathways' added !
	44880	view	10:08, 6 October 2011	MartijnVanIersel	Modified description
	41042	view	23:16, 1 March 2011	MaintBot	Removed redundant pathway information and comments
	39757	view	07:19, 17 January 2011	AlexanderPico	more specific title
	38881	view	18:56, 24 September 2010	Khanspers	Changed line types
	38830	view	11:54, 24 September 2010	Jildau	nucleus
	32036	view	13:27, 14 August 2009	MaintBot	Fixed group labels
	29720	view	21:20, 1 June 2009	Khanspers	added ref for metabolite
	28165	view	09:44, 29 January 2009	Thomas	Modified categories
	28164	view	09:44, 29 January 2009	Thomas	Modified description
	28163	view	09:42, 29 January 2009	Thomas	extended pathway
	20675	view	11:29, 14 November 2008	MaintBot	[[Pathway:Homo sapiens:Keap1-Nrf2]] moved to [[Pathway:WP3]]: Moved to stable identifier
	20254	view	08:19, 28 October 2008	Hubert	Periodical save, work in progress
	19325	view	11:38, 2 October 2008	Hubert	New pathway

External references

DataNodes

View all...

Name	Type	Database reference	Comment
6-HITC	Metabolite		Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
C/EBP-beta	GeneProduct	1051 (Entrez Gene)
Caffeic acid phenethyl ester	Metabolite
Curcumin	Metabolite	HMDB02269 (HMDB)
ERK	GeneProduct	2048 (Entrez Gene)
GCLC	GeneProduct	2729 (Entrez Gene)
GCLM	GeneProduct	2730 (Entrez Gene)
GSTA2	GeneProduct	4627 (HUGO)
HO-1	GeneProduct	3162 (Entrez Gene)
JNK	GeneProduct	5599 (Entrez Gene)
KEAP1	GeneProduct	9817 (Entrez Gene)
MAF	GeneProduct	4094 (Entrez Gene)
NQO1	GeneProduct	1728 (Entrez Gene)
NRF2	GeneProduct	4780 (Entrez Gene)
P38	GeneProduct	7965 (Entrez Gene)
PI3K	GeneProduct	5290 (Entrez Gene)
PKC	GeneProduct	5578 (Entrez Gene)
Sulforaphane	Metabolite	5350 (PubChem)

Annotated Interactions

No annotated interactions