Insulin Signaling (Pan troglodytes)
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Transcriptional Regulators & Immediate Early Genes
PI 3-Kinase
Translation Regulation
Metabolic Regulation
Insulin Receptor Substrates
Tor Signaling
p70 S6 Kinases
PDK/Akt Signaling
Ras-MAPK Signaling
Glucose Transport
Vesicular Trafficking
MEK/MAP Kinases
p90 Rsk Kinases
Modulators of Insulin Action
SHC3
IGF1R
INSR
MAP2K6
MAP3K13
FOS
PIK3C2A
RPS6KA4
MAP3K1
MAP4K2
KIF5B
MAP2K7
FRAP1
GSK3A
EHD2
RAC1
PFKM
RRAD
IRS1
HRAS
MAPK12
GAB1
PRKAA1
PTEN
STXBP3
RPS6KA2
MAP3K11
MAPK4
MAP3K7
ARF1
SH2B2
MAP3K12
EGR1
GYS1
MAP3K5
EHD1
GYG1
RPS6KB1
PIK3C2G
TSC1
MAPK1
IRS4
MAP4K3
FOXO3A
TSC2
MAPK14
SNX26
MAP3K2
PRKAA2
RAB4A
SGK
PIK3R3
MAP2K3
MAP2K5
SLC2A4
EIF4EBP1
SHC1
STXBP4
PSCD3
PRKCH
EIF4E
KIF3A
MAPK9
PIK3R2
RPS6KA5
PDPK1
MAPK3
PTPN1
CAP1
PIK3CD
PIK3R4
MAP3K6
SOS2
SRF
RPS6KA3
MAP3K4
STX4A
PFKL
SGK2
VAMP2
PIK3CB
MAPK8
INPPL1
RAPGEF1
ARF6
SOS1
PRKCD
MAP2K2
RHOXF2
STXBP1
MYO1C
GRB14
MAP4K4
PTPRF
CBLB
FLOT1
MAP3K9
SNAP25
MAP2K1
MAP4K1
MAPK11
INPP4A
RHOQ
PIK3R1
ELK1
MAP2K4
PRKCA
PIK3C3
GSK3B
XBP1
JUN
MINK1
SLC2A1
PTPN11
IKBKB
CRK
PIK3CG
IRS2
TBC1D4
MAP3K14
GRB2
MAPK13
MAPK10
SNAP23
TRIB3
PRKCB1
PRKCQ
RAC2
CBL
MAP4K5
RPS6KB2
AKT1
SORBS1
CBLC
PRKCI
MAP3K8
GRB10
MAPK7
MAPK6
PRKCZ
RAF1
FOXO1
GYS2
SOCS3
SGK3
FLOT2
SHC2
RPS6KA6
PPP1R3A
MAPK8
RHEB
RPS6KA1
PIK3CA
RHOJ
AKT2
MAP3K3
LIPE
STXBP2
ENPP1
SOCS1
MAP3K10
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP481(r28132)
with a 72% conversion rate.
Try the New WikiPathways
View approved pathways at
the new wikipathways.org
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Quality Tags
Ontology Terms
Saving...
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Bibliography
Bevan P; ''Insulin signalling.''; J Cell Sci, 2001
PubMed
Europe PMC
Scholia
Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991
PubMed
Europe PMC
Scholia
Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
69319
view
18:44, 8 July 2013
MaintBot
Updated to 2013 gpml schema
48148
view
18:41, 9 May 2012
MaintBot
Updating from human to fix xrefs
41629
view
02:03, 2 March 2011
MaintBot
Removed redundant pathway information and comments
34356
view
22:24, 9 December 2009
MaintBot
Automatic update of empty xrefs
33517
view
15:19, 30 November 2009
MaintBot
Removed group label
31557
view
21:54, 13 August 2009
MaintBot
Fixed text labels
30416
view
21:15, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
AKT1
GeneProduct
740898 (Entrez Gene)
AKT2
GeneProduct
456035 (Entrez Gene)
ARF1
GeneProduct
ARF6
GeneProduct
452892 (Entrez Gene)
CAP1
GeneProduct
746432 (Entrez Gene)
CBL
GeneProduct
451690 (Entrez Gene)
CBLB
GeneProduct
460566 (Entrez Gene)
CBLC
GeneProduct
CRK
GeneProduct
747142 (Entrez Gene)
EGR1
GeneProduct
462097 (Entrez Gene)
EHD1
GeneProduct
744047 (Entrez Gene)
EHD2
GeneProduct
456170 (Entrez Gene)
EIF4E
GeneProduct
EIF4EBP1
GeneProduct
464114 (Entrez Gene)
ELK1
GeneProduct
ENPP1
GeneProduct
463002 (Entrez Gene)
FLOT1
GeneProduct
471961 (Entrez Gene)
FLOT2
GeneProduct
454537 (Entrez Gene)
FOS
GeneProduct
453047 (Entrez Gene)
FOXO1
GeneProduct
467352 (Entrez Gene)
FOXO3A
GeneProduct
FRAP1
GeneProduct
GAB1
GeneProduct
461516 (Entrez Gene)
GRB10
GeneProduct
463410 (Entrez Gene)
GRB14
GeneProduct
459695 (Entrez Gene)
GRB2
GeneProduct
737245 (Entrez Gene)
GSK3A
GeneProduct
456071 (Entrez Gene)
GSK3B
GeneProduct
470896 (Entrez Gene)
GYG1
GeneProduct
460765 (Entrez Gene)
GYS1
GeneProduct
GYS2
GeneProduct
465336 (Entrez Gene)
HRAS
GeneProduct
466302 (Entrez Gene)
IGF1R
GeneProduct
453676 (Entrez Gene)
IKBKB
GeneProduct
472749 (Entrez Gene)
INPP4A
GeneProduct
470448 (Entrez Gene)
INPPL1
GeneProduct
451403 (Entrez Gene)
INSR
GeneProduct
IRS1
GeneProduct
459985 (Entrez Gene)
IRS2
GeneProduct
452657 (Entrez Gene)
IRS4
GeneProduct
JUN
GeneProduct
456893 (Entrez Gene)
KIF3A
GeneProduct
450168 (Entrez Gene)
KIF5B
GeneProduct
450390 (Entrez Gene)
LIPE
GeneProduct
MAP2K1
GeneProduct
450188 (Entrez Gene)
MAP2K2
GeneProduct
456390 (Entrez Gene)
MAP2K3
GeneProduct
454515 (Entrez Gene)
MAP2K4
GeneProduct
455065 (Entrez Gene)
MAP2K5
GeneProduct
453532 (Entrez Gene)
MAP2K6
GeneProduct
468310 (Entrez Gene)
MAP2K7
GeneProduct
743199 (Entrez Gene)
MAP3K1
GeneProduct
MAP3K10
GeneProduct
MAP3K11
GeneProduct
451326 (Entrez Gene)
MAP3K12
GeneProduct
451940 (Entrez Gene)
MAP3K13
GeneProduct
737524 (Entrez Gene)
MAP3K14
GeneProduct
MAP3K2
GeneProduct
736244 (Entrez Gene)
MAP3K3
GeneProduct
MAP3K4
GeneProduct
MAP3K5
GeneProduct
463023 (Entrez Gene)
MAP3K6
GeneProduct
456674 (Entrez Gene)
MAP3K7
GeneProduct
462888 (Entrez Gene)
MAP3K8
GeneProduct
450384 (Entrez Gene)
MAP3K9
GeneProduct
467498 (Entrez Gene)
MAP4K1
GeneProduct
MAP4K2
GeneProduct
451301 (Entrez Gene)
MAP4K3
GeneProduct
459173 (Entrez Gene)
MAP4K4
GeneProduct
459459 (Entrez Gene)
MAP4K5
GeneProduct
467451 (Entrez Gene)
MAPK10
GeneProduct
461358 (Entrez Gene)
MAPK11
GeneProduct
MAPK12
GeneProduct
MAPK13
GeneProduct
462644 (Entrez Gene)
MAPK14
GeneProduct
450161 (Entrez Gene)
MAPK1
GeneProduct
458680 (Entrez Gene)
MAPK3
GeneProduct
454037 (Entrez Gene)
MAPK4
GeneProduct
MAPK6
GeneProduct
453439 (Entrez Gene)
MAPK7
GeneProduct
MAPK8
GeneProduct
450445 (Entrez Gene)
MAPK9
GeneProduct
462336 (Entrez Gene)
MINK1
GeneProduct
454455 (Entrez Gene)
MYO1C
GeneProduct
750403 (Entrez Gene)
PDPK1
GeneProduct
PFKL
GeneProduct
458602 (Entrez Gene)
PFKM
GeneProduct
451863 (Entrez Gene)
PIK3C2A
GeneProduct
451052 (Entrez Gene)
PIK3C2G
GeneProduct
PIK3C3
GeneProduct
455385 (Entrez Gene)
PIK3CA
GeneProduct
460858 (Entrez Gene)
PIK3CB
GeneProduct
PIK3CD
GeneProduct
457922 (Entrez Gene)
PIK3CG
GeneProduct
463649 (Entrez Gene)
PIK3R1
GeneProduct
461836 (Entrez Gene)
PIK3R2
GeneProduct
455855 (Entrez Gene)
PIK3R3
GeneProduct
PIK3R4
GeneProduct
460692 (Entrez Gene)
PPP1R3A
GeneProduct
463666 (Entrez Gene)
PRKAA1
GeneProduct
PRKAA2
GeneProduct
741802 (Entrez Gene)
PRKCA
GeneProduct
PRKCB1
GeneProduct
PRKCD
GeneProduct
PRKCH
GeneProduct
746068 (Entrez Gene)
PRKCI
GeneProduct
450143 (Entrez Gene)
PRKCQ
GeneProduct
450288 (Entrez Gene)
PRKCZ
GeneProduct
743533 (Entrez Gene)
PSCD3
GeneProduct
PTEN
GeneProduct
466142 (Entrez Gene)
PTPN11
GeneProduct
PTPN1
GeneProduct
469970 (Entrez Gene)
PTPRF
GeneProduct
456828 (Entrez Gene)
RAB4A
GeneProduct
RAC1
GeneProduct
RAC2
GeneProduct
742575 (Entrez Gene)
RAF1
GeneProduct
460182 (Entrez Gene)
RAPGEF1
GeneProduct
464812 (Entrez Gene)
RHEB
GeneProduct
463880 (Entrez Gene)
RHOJ
GeneProduct
452960 (Entrez Gene)
RHOQ
GeneProduct
740809 (Entrez Gene)
RHOXF2
GeneProduct
473763 (Entrez Gene)
RPS6KA1
GeneProduct
RPS6KA2
GeneProduct
RPS6KA3
GeneProduct
RPS6KA4
GeneProduct
451715 (Entrez Gene)
RPS6KA5
GeneProduct
739162 (Entrez Gene)
RPS6KA6
GeneProduct
RPS6KB1
GeneProduct
468426 (Entrez Gene)
RPS6KB2
GeneProduct
746903 (Entrez Gene)
RRAD
GeneProduct
741038 (Entrez Gene)
SGK
GeneProduct
SGK2
GeneProduct
740699 (Entrez Gene)
SGK3
GeneProduct
464217 (Entrez Gene)
SH2B2
GeneProduct
741557 (Entrez Gene)
SHC1
GeneProduct
457351 (Entrez Gene)
SHC2
GeneProduct
SHC3
GeneProduct
450176 (Entrez Gene)
SLC2A1
GeneProduct
SLC2A4
GeneProduct
468443 (Entrez Gene)
SNAP23
GeneProduct
453365 (Entrez Gene)
SNAP25
GeneProduct
458096 (Entrez Gene)
SNX26
GeneProduct
SOCS1
GeneProduct
737070 (Entrez Gene)
SOCS3
GeneProduct
454921 (Entrez Gene)
SORBS1
GeneProduct
450628 (Entrez Gene)
SOS1
GeneProduct
459171 (Entrez Gene)
SOS2
GeneProduct
SRF
GeneProduct
462709 (Entrez Gene)
STX4A
GeneProduct
STXBP1
GeneProduct
STXBP2
GeneProduct
741963 (Entrez Gene)
STXBP3
GeneProduct
737947 (Entrez Gene)
STXBP4
GeneProduct
468411 (Entrez Gene)
TBC1D4
GeneProduct
467286 (Entrez Gene)
TRIB3
GeneProduct
TSC1
GeneProduct
464818 (Entrez Gene)
TSC2
GeneProduct
468086 (Entrez Gene)
VAMP2
GeneProduct
747237 (Entrez Gene)
XBP1
GeneProduct
458735 (Entrez Gene)
Annotated Interactions
No annotated interactions
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View approved pathways at the new wikipathways.org.Quality Tags
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Bibliography
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External references
DataNodes
Annotated Interactions
No annotated interactions