Hypothetical network for drug addiction (Gallus gallus)
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1
Regulation of gap junction
Long-term potentiation
mGluR
NMDAR
Local Translation
Regulation of actin cytoskeleton
Gap junction
GnRH Signal pathway
Neuroactive ligand-receptor
interaction
Strong depolarization
AMPAR
Gonadotropins gene
expression & secretion
MAPK signaling pathway
GRIN2A
PRKCE
MAPK1
Gs
GRIA4
KRIT1
Cyclic AMP
GRIN2C
GRIA1
ACTA1
connexin
MAP2K2
TERF2IP
MAP2K1
Ca++
GRIN2B
DRD2
ADCY1
GRIA2
CAMK2
connexin
NISCH
PPA1
ZHX2
ADCY8
Gi
DRD1
GRIA3
PKA
GRIN1
CAMK4
GRIN2D
GRM5
ERK1
DRD4
D-Glutamate
ADCY1
GRM1
CREB1
PKA
Description
Adapted from figure 2 in
Li et al.
.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP666(r29740)
with a 70% conversion rate.
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Bibliography
Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
118082
view
10:44, 24 May 2021
Eweitz
Modified title
107107
view
14:18, 17 September 2019
MaintBot
ChEBI identifier normalization
102313
view
13:35, 18 December 2018
Egonw
Fixed the ChEBI identifier for Ca2+
88658
view
15:15, 12 August 2016
Jmelius
Ontology Term : 'substance dependence disease pathway' added !
68878
view
17:22, 8 July 2013
MaintBot
Updated to 2013 gpml schema
41019
view
22:57, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33940
view
18:13, 9 December 2009
MaintBot
Automatic update of empty xrefs
33447
view
14:59, 30 November 2009
MaintBot
Removed group label
31502
view
21:33, 13 August 2009
MaintBot
Fixed text labels
30333
view
20:47, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ACTA1
GeneProduct
421534 (Entrez Gene)
ADCY1
GeneProduct
420788 (Entrez Gene)
ADCY8
GeneProduct
420328 (Entrez Gene)
CAMK2
GeneProduct
CAMK4
GeneProduct
723973 (Entrez Gene)
CREB1
GeneProduct
395099 (Entrez Gene)
Ca++
Metabolite
29320 (ChEBI)
Cyclic AMP
Metabolite
17489 (ChEBI)
D-Glutamate
Metabolite
15966 (ChEBI)
DRD1
GeneProduct
427633 (Entrez Gene)
DRD2
GeneProduct
428252 (Entrez Gene)
DRD4
GeneProduct
423016 (Entrez Gene)
ERK1
GeneProduct
GRIA1
GeneProduct
414893 (Entrez Gene)
GRIA2
GeneProduct
414894 (Entrez Gene)
GRIA3
GeneProduct
396138 (Entrez Gene)
GRIA4
GeneProduct
396137 (Entrez Gene)
GRIN1
GeneProduct
404296 (Entrez Gene)
GRIN2A
GeneProduct
427678 (Entrez Gene)
GRIN2B
GeneProduct
417965 (Entrez Gene)
GRIN2C
GeneProduct
GRIN2D
GeneProduct
GRM1
GeneProduct
421614 (Entrez Gene)
GRM5
GeneProduct
373933 (Entrez Gene)
Gi
GeneProduct
Gs
GeneProduct
KRIT1
GeneProduct
420549 (Entrez Gene)
MAP2K1
GeneProduct
415549 (Entrez Gene)
MAP2K2
GeneProduct
396349 (Entrez Gene)
MAPK1
GeneProduct
373953 (Entrez Gene)
NISCH
GeneProduct
415893 (Entrez Gene)
PKA
GeneProduct
PPA1
GeneProduct
769424 (Entrez Gene)
PRKCE
GeneProduct
421409 (Entrez Gene)
TERF2IP
GeneProduct
395122 (Entrez Gene)
ZHX2
GeneProduct
420351 (Entrez Gene)
connexin
GeneProduct
Annotated Interactions
No annotated interactions
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Discussion
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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Bibliography
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External references
DataNodes
Annotated Interactions
No annotated interactions