Ovarian Infertility Genes (Danio rerio)

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OoplasmGranulosa CellCytoplasmNucleusNucleusOocytemlh1ZP3LOC556700zgc:162280gdf9LOC570030ZP3cdkn1bPGRvdrbTF2Dncor1SYNE2PRLRNRIP1GJA4CYP19A1ESR2egr1ZP2si:dkey-91f15.2zgc:153726bmpr1bcebpbLOC556700Fig-alphadmc1PTGER2dazlGJA4LOC794566lhcgrNR5A1fshrsmad3b


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Comments

GenMAPP notes 
Ovarian ’bottleneck’ genes associated with infertility

A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility phenotypes. The individual gene pages in the OKdb (Ovarian Kaleidoscope Database: http://ovary.stanford.edu) contain information on associated fertility phenotypes sorted by ovarian and nonovarian defects and by subfertility or infertility. If one searches for null mutations (under ’mutation type’) causing infertility (’infertile - ovarian defect’, under ’female fertility status’) in mice (under ’species’), 44 gene entries are found. The expression of these infertility genes in the oocyte and granulosa cells together with their cellular localization is presented in Ovarian Infertility gene map. The theca cell genes are not presented because most publications emphasize granulosa cell studies.

GenMAPP remarks 
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HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP34(r20749) with a 57% conversion rate.

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History

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CompareRevisionActionTimeUserComment
59544view17:17, 1 March 2013MaintBotDeleted pathway: Human pw
40820view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
34208view21:30, 9 December 2009MaintBotAutomatic update of empty xrefs
31930view12:55, 14 August 2009MaintBotFixed group labels
31050view01:21, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CYP19A1GeneProduct
ESR2GeneProduct
Fig-alphaGeneProduct
GJA4GeneProduct
LOC556700GeneProduct556700 (Entrez Gene)
LOC570030GeneProduct570030 (Entrez Gene)
LOC794566GeneProduct794566 (Entrez Gene)
NR5A1GeneProduct
NRIP1GeneProduct
PGRGeneProduct569575 (Entrez Gene)
PRLRGeneProduct
PTGER2GeneProduct
SYNE2GeneProduct
TF2DGeneProduct
ZP2GeneProduct30593 (Entrez Gene)
ZP3GeneProduct30594 (Entrez Gene)
bmpr1bGeneProduct30742 (Entrez Gene)
cdkn1bGeneProduct368329 (Entrez Gene)
cebpbGeneProduct140814 (Entrez Gene)
dazlGeneProduct58039 (Entrez Gene)
dmc1GeneProduct553953 (Entrez Gene)
egr1GeneProduct30498 (Entrez Gene)
fshrGeneProduct195820 (Entrez Gene)
gdf9GeneProduct497643 (Entrez Gene)
lhcgrGeneProduct402920 (Entrez Gene)
mlh1GeneProduct393632 (Entrez Gene)
ncor1GeneProduct393246 (Entrez Gene)
si:dkey-91f15.2GeneProduct570520 (Entrez Gene)
smad3bGeneProduct326283 (Entrez Gene)
vdrbGeneProduct564511 (Entrez Gene)
zgc:153726GeneProduct777730 (Entrez Gene)
zgc:162280GeneProduct799608 (Entrez Gene)

Annotated Interactions

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