G1 to S cell cycle control (Pan troglodytes)
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Khanspers
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p
Rb
p
G1 Cyclin
Dependant Cyclases
TTTCC/GCGC
origin recognition complex
Cell cycle DNA replication genes
phosphorylation of proteins
involved in G1/S transition
G1/S transition Cyclin
Dependent Kinases
p
p
G1/S Cell Cycle
dp1
e
u
Checkpoint
G1/S transition Phase
Degradation
cak
inactive
Cyclin Es
DNA polymerases
e
G2 Phase-M phase
u
G1 Phase
b
b
p
p
E2f
DNA replication
u
Cyclin Ds
TFDP1
CDK7
CCNA1
RB1
E2F2
CCND1
CCNE1
CCNB1
CDK6
E2F5
RPA3
ORC4L
TFDP1
ORC6L
CyclinD
MCM2
RB1
MYC
MCM7
RBL1
ORC5L
MNAT1
CCND2
CDK4
CREB1
TFDP2
RHOXF2
ATM
CyclinD
WEE1
CDKN1A
CDKN2B
CDKN2A
Cdk
RPA1
CCND3
PRIM1
MCM5
CREB3
CDC25A
CDK6
E2F3
CCNG2
POLE2
MYT1
TP53
CDKN1C
CCNE1
E2F6
MCM6
CCNH
PCNA
CDKN2C
CDKN1B
Cdk
E2F4
CDK4
MDM2
CREB3L3
ORC1L
POLE
CDKN2D
CCNE1
RPA2
E2f
POLA2
CCNE2
PRIM2A
CREB3L1
CREB3L4
ORC2L
E2F1
CDK7
RB1
MCM3
CDK
ATF6B
E2f
MCM4
GADD45A
ORC3L
CDK
CDK2
CDC45L
TP53
RHOXF2
Description
No description
Comments
GenMAPP notes
Adapted from
http://www.genomeknowledge.org/
, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP45(r20771)
with a 81% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
95751
view
13:54, 19 January 2018
Mkutmon
Homology conversion update
69254
view
18:36, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67272
view
10:29, 26 June 2013
Christine Chichester
Ontology Term : 'G1/S DNA damage checkpoint pathway' added !
48163
view
20:20, 9 May 2012
MaintBot
Updating from human to fix xrefs
41561
view
01:59, 2 March 2011
MaintBot
Removed redundant pathway information and comments
35832
view
22:17, 17 February 2010
Khanspers
Added lit ref
35831
view
22:16, 17 February 2010
Khanspers
Modified description
34291
view
22:01, 9 December 2009
MaintBot
Automatic update of empty xrefs
33608
view
09:59, 1 December 2009
MaintBot
Removed group label
31622
view
22:19, 13 August 2009
MaintBot
Fixed text labels
30528
view
21:52, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ATF6B
GeneProduct
745411 (Entrez Gene)
ATM
GeneProduct
451530 (Entrez Gene)
CCNA1
GeneProduct
467260 (Entrez Gene)
CCNB1
GeneProduct
461835 (Entrez Gene)
CCND1
GeneProduct
747688 (Entrez Gene)
CCND2
GeneProduct
747123 (Entrez Gene)
CCND3
GeneProduct
462689 (Entrez Gene)
CCNE1
GeneProduct
455914 (Entrez Gene)
CCNE2
GeneProduct
464292 (Entrez Gene)
CCNG2
GeneProduct
461229 (Entrez Gene)
CCNH
GeneProduct
739351 (Entrez Gene)
CDC25A
GeneProduct
460341 (Entrez Gene)
CDC45L
GeneProduct
458651 (Entrez Gene)
CDK
GeneProduct
CDK2
GeneProduct
467032 (Entrez Gene)
CDK4
GeneProduct
452025 (Entrez Gene)
CDK6
GeneProduct
746968 (Entrez Gene)
CDK7
GeneProduct
462378 (Entrez Gene)
CDKN1A
GeneProduct
747442 (Entrez Gene)
CDKN1B
GeneProduct
466947 (Entrez Gene)
CDKN1C
GeneProduct
CDKN2A
GeneProduct
465021 (Entrez Gene)
CDKN2B
GeneProduct
CDKN2C
GeneProduct
469319 (Entrez Gene)
CDKN2D
GeneProduct
745942 (Entrez Gene)
CREB1
GeneProduct
459901 (Entrez Gene)
CREB3
GeneProduct
CREB3L1
GeneProduct
451704 (Entrez Gene)
CREB3L3
GeneProduct
468672 (Entrez Gene)
CREB3L4
GeneProduct
457341 (Entrez Gene)
Cdk
GeneProduct
CyclinD
GeneProduct
E2F1
GeneProduct
E2F2
GeneProduct
469153 (Entrez Gene)
E2F3
GeneProduct
E2F4
GeneProduct
454158 (Entrez Gene)
E2F5
GeneProduct
747256 (Entrez Gene)
E2F6
GeneProduct
470148 (Entrez Gene)
E2f
GeneProduct
GADD45A
GeneProduct
456929 (Entrez Gene)
MCM2
GeneProduct
460668 (Entrez Gene)
MCM3
GeneProduct
462763 (Entrez Gene)
MCM4
GeneProduct
472757 (Entrez Gene)
MCM5
GeneProduct
458790 (Entrez Gene)
MCM6
GeneProduct
741695 (Entrez Gene)
MCM7
GeneProduct
472460 (Entrez Gene)
MDM2
GeneProduct
742141 (Entrez Gene)
MNAT1
GeneProduct
452954 (Entrez Gene)
MYC
GeneProduct
464393 (Entrez Gene)
MYT1
GeneProduct
458428 (Entrez Gene)
ORC1L
GeneProduct
456857 (Entrez Gene)
ORC2L
GeneProduct
459868 (Entrez Gene)
ORC3L
GeneProduct
462876 (Entrez Gene)
ORC4L
GeneProduct
459647 (Entrez Gene)
ORC5L
GeneProduct
463636 (Entrez Gene)
ORC6L
GeneProduct
465140 (Entrez Gene)
PCNA
GeneProduct
458081 (Entrez Gene)
POLA2
GeneProduct
451318 (Entrez Gene)
POLE2
GeneProduct
452888 (Entrez Gene)
POLE
GeneProduct
467165 (Entrez Gene)
PRIM1
GeneProduct
746924 (Entrez Gene)
PRIM2A
GeneProduct
RB1
GeneProduct
452715 (Entrez Gene)
RBL1
GeneProduct
735916 (Entrez Gene)
RHOXF2
GeneProduct
473763 (Entrez Gene)
RPA1
GeneProduct
454414 (Entrez Gene)
RPA2
GeneProduct
456680 (Entrez Gene)
RPA3
GeneProduct
472290 (Entrez Gene)
TFDP1
GeneProduct
465967 (Entrez Gene)
TFDP2
GeneProduct
460743 (Entrez Gene)
TP53
GeneProduct
455214 (Entrez Gene)
WEE1
GeneProduct
466440 (Entrez Gene)
Annotated Interactions
No annotated interactions
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