Aflatoxin B1 metabolism (Rattus norvegicus)

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1-3, 5, 7...4, 64, 6nonenzymaticDNA adductsnonenzymatic(pH-dependent)Aflatoxin B1 C6-monoaldehydeAflatoxin Q1GSTM1Aflatoxin M1Cyp1a2Aflatoxin B1 C8-monoaldehydeAflatoxin B1 C6-monoalcoholAflatoxin B1 C8-monoalcoholAflatoxin B1 dialdehydeAflatoxin M1 epoxideCYP2A13Cyp1a2Aflatoxin B1 exo-8,9-epoxide-GSHCyp1a2Akr7a3Aflatoxin B1-6,8-dialcoholAflatoxin B1 exo-8,9-epoxideAflatoxin-endo-B1-8,9-epoxideaflatoxin B1CYP2A13Akr7a2Aflatoxin B1 8,9-dihydrodiolEphx1Gstt1CYP3A4CYP3A4


Description

Aflatoxins are naturally occurring mycotoxins that are produced by many species of Aspergillus, a fungus, most notably Aspergillus flavus and Aspergillus parasiticus. After entering the body, aflatoxins are metabolized by the liver to a reactive intermediate, aflatoxin M1, an epoxide. Aflatoxin B1 is considered the most toxic and is produced by both Aspergillus flavus and Aspergillus parasiticus. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP699(r30253) with a 58% conversion rate.

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Bibliography

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  1. Raney KD, Coles B, Guengerich FP, Harris TM; ''The endo-8,9-epoxide of aflatoxin B1: a new metabolite.''; Chem Res Toxicol, 1992 PubMed Europe PMC Scholia
  2. He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY; ''Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract.''; Int J Cancer, 2006 PubMed Europe PMC Scholia
  3. Zhu LR, Thomas PE, Lu G, Reuhl KR, Yang GY, Wang LD, Wang SL, Yang CS, He XY, Hong JY; ''CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody.''; Drug Metab Dispos, 2006 PubMed Europe PMC Scholia
  4. Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM; ''Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.''; Chem Res Toxicol, 2001 PubMed Europe PMC Scholia
  5. Guengerich FP; ''Cytochrome P450s and other enzymes in drug metabolism and toxicity.''; AAPS J, 2006 PubMed Europe PMC Scholia
  6. Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM; ''Reaction of aflatoxin B(1) oxidation products with lysine.''; Chem Res Toxicol, 2002 PubMed Europe PMC Scholia
  7. Kensler TW, Qian GS, Chen JG, Groopman JD; ''Translational strategies for cancer prevention in liver.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
  8. Stewart RK, Smith GB, Donnelly PJ, Reid KR, Petsikas D, Conlan AA, Massey TE; ''Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B(1) in human lung: differential cellular distribution and lack of significance of the GSTM1 genetic polymorphism.''; Carcinogenesis, 1999 PubMed Europe PMC Scholia
  9. Tiemersma EW, Omer RE, Bunschoten A, van't Veer P, Kok FJ, Idris MO, Kadaru AM, Fedail SS, Kampman E; ''Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma.''; Cancer Epidemiol Biomarkers Prev, 2001 PubMed Europe PMC Scholia
  10. Barski OA, Tipparaju SM, Bhatnagar A; ''The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.''; Drug Metab Rev, 2008 PubMed Europe PMC Scholia
  11. Jin Y, Penning TM; ''Aldo-keto reductases and bioactivation/detoxication.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
106956view13:41, 17 September 2019MaintBotHMDB identifier normalization
69326view18:49, 8 July 2013MaintBotUpdated to 2013 gpml schema
67031view09:56, 26 June 2013Christine ChichesterOntology Term : 'aflatoxin metabolic pathway' added !
58917view04:52, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
57054view15:52, 20 January 2013EgonwUsed "PubChem-compound"
53484view23:33, 7 November 2012AndraSpecify description
53483view23:30, 7 November 2012Andra
48273view23:20, 17 May 2012KhanspersUpdating PubChem xrefs
48262view21:58, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41637view02:33, 2 March 2011MaintBotRemoved redundant pathway information and comments
35018view08:27, 11 February 2010ThomasModified description
34040view18:59, 9 December 2009MaintBotAutomatic update of empty xrefs
32309view13:19, 15 August 2009MaintBotFixed text labels
31898view12:45, 14 August 2009MaintBotFixed group labels
31338view20:24, 13 August 2009MaintBotFixed text labels
30985view00:54, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Aflatoxin B1 8,9-dihydrodiolMetabolite3035008 (PubChem)
Aflatoxin B1 C6-monoalcoholMetabolite
Aflatoxin B1 C6-monoaldehydeMetabolite
Aflatoxin B1 C8-monoalcoholMetabolite
Aflatoxin B1 C8-monoaldehydeMetabolite
Aflatoxin B1 dialdehydeMetabolite
Aflatoxin B1 exo-8,9-epoxide-GSHMetabolite5460816 (PubChem)
Aflatoxin B1 exo-8,9-epoxideMetabolite104756 (PubChem)
Aflatoxin B1-6,8-dialcoholMetabolite
Aflatoxin M1 epoxideMetabolite
Aflatoxin M1Metabolite15558498 (PubChem)
Aflatoxin Q1Metabolite104757 (PubChem)
Aflatoxin-endo-B1-8,9-epoxideMetabolite
Akr7a2GeneProductENSRNOG00000017780 (Ensembl Rat)
Akr7a3GeneProductENSRNOG00000017899 (Ensembl Rat)
CYP2A13GeneProduct
CYP3A4GeneProduct
Cyp1a2GeneProductENSRNOG00000016173 (Ensembl Rat)
Ephx1GeneProductENSRNOG00000003515 (Ensembl Rat)
GSTM1GeneProduct24423 (Entrez Gene)
Gstt1GeneProductENSRNOG00000001242 (Ensembl Rat)
aflatoxin B1MetaboliteHMDB06552 (HMDB)

Annotated Interactions

No annotated interactions
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