ACE inhibitor pathway (Gallus gallus)

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1Cell MembraneAGTR2BradykininACEKNG1AGTRENACE InhibitorAGTR1ACEBDKRB2Angiotensin IIAldosteroneAngiotensin INOS3


Description

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

Comments

GenMAPP notes 
https://www.pharmgkb.org/search/pathway/ace-inhibitor.jsp Model non-tissue specific cell displaying genes which may be involved in the ACE inhibitor pathway.
GenMAPP remarks 
Adapted from PharmGKB (right click for info)
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP554(r30178) with a 77% conversion rate.

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Bibliography

  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117188view10:30, 18 May 2021EweitzModified title
106121view12:02, 16 August 2019MaintBotHMDB identifier normalization
72067view17:33, 24 October 2013MaintBotUpdated data sources
68802view17:14, 8 July 2013MaintBotUpdated to 2013 gpml schema
67022view09:55, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
57060view16:51, 20 January 2013EgonwUsed "PubChem-compound"
40935view22:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
35046view09:35, 11 February 2010Thomasremoved genmapp notes (invalid link)
35038view09:28, 11 February 2010ThomasModified description
33478view15:06, 30 November 2009MaintBotRemoved group label
30370view20:58, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE InhibitorMetabolite
ACEGeneProduct419953 (Entrez Gene)
AGTGeneProduct421543 (Entrez Gene)
AGTR1GeneProduct396065 (Entrez Gene)
AGTR2GeneProduct428708 (Entrez Gene)
AldosteroneMetaboliteC01780 (Kegg Compound)
Angiotensin IMetabolite3081372 (PubChem)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
BDKRB2GeneProduct428906 (Entrez Gene)
BradykininMetaboliteHMDB04246 (HMDB)
KNG1GeneProduct424957 (Entrez Gene)
NOS3GeneProduct
RENGeneProduct

Annotated Interactions

No annotated interactions
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