DNA replication (Saccharomyces cerevisiae)

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1-3DNA polymerase alpha: primase: origin complexOrc2Mcm6Processive complexCdc6RFC40Orc1dUTP5. Leading/lagging strand synthesisaOrc5Orc4OriginUbiquitinOrc42. Activation of the pre-replicative complexOrc5RNA primer-DNA primerMcm3Cdc6RNA primer-DNA primer:origin duplex:PCNACdt1Cdt1Cdt1HOMOLOGY MAPPOrc complexOrc3Cdt1RNA PrimerOrc5with the replication forkMcm4UbiquitinUTPOrc23. DNA replication initiationOrc2RFC140p180Ubiquitinated Orc1Orc ComplexMcm31. Assembly of the pre-replicative complexMcm5Pre-replicative complexMcm6GemininMcm2PCNA homotrimerOrc3CTPPhosphorylation of Mcm 2-7 complexRFC Heteropentamer:RNA primer-DNA primer:Degraded by proteasome in cytosol4. Switching of origins to post-replicative stateDNA PolymerasePrimaseCdt1Orc2Mcm2Mcm7RFC38Mcm4p70Phosphorylated Orc1RFC Heteropentamer:RNA primer-DNA primerRFC37Ubiquitinated Cdc6RNA primer-DNA primerDNA polymerase alpha: primase: origin complexp58p49Mcm10RFC36Orc3Mcm5Phosphorylated Cdc6Orc complexMcm7Degraded by proteasome in cytosolMcm 4,6,7 trimer forms and associatesOrc complexPre-replicative complexOrc3Cdc6Orc complexCdc6ATPCDC46MCM3RFC5GMNNCDC47CDC7MCM10RFC1RFC2ORC1LMCM6RFA2RPL40ACDC45MCM2PRI1ATPRPA4ATPPOLD4HYS2DPB2POL12UBI4dCTPRFC4POL1ADPRFC3POL30ATPPRI2POLD3RPA3ORC4LCDC2ORC2CDK2ORC5LADPdGTPdATPRFA1ORC3LGTPPOL2ORC6LCDC54ASKCDC6CDT1


Description

No description

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Marahrens Y, Stillman B; ''A yeast chromosomal origin of DNA replication defined by multiple functional elements.''; Science, 1992 PubMed Europe PMC Scholia
  3. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117289view10:58, 20 May 2021EweitzModified title
102295view19:29, 17 December 2018KhanspersModified description
78398view10:25, 7 January 2015MaintBotadded missing graphIds
76275view21:24, 25 June 2014KhanspersModified description
76274view21:24, 25 June 2014Khanspersremoved genmapp comments
76273view21:22, 25 June 2014Khanspersoverhaul
71354view18:03, 17 October 2013MaintBotAutomated update of data sources
69761view11:05, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69672view20:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67159view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41916view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
35199view15:38, 11 February 2010ThomasModified description
35198view15:38, 11 February 2010ThomasModified description
35197view15:37, 11 February 2010Thomasadded literature
34367view22:36, 9 December 2009MaintBotAutomatic update of empty xrefs
20699view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:DNA replication Reactome]] moved to [[Pathway:WP13]]: Moved to stable identifier
12692view07:58, 17 May 2008MaintBotautomated metabolite conversion
8540view14:02, 7 January 2008MaintBotAdded to category $category
19420view14:02, 7 January 2008D.KorenUploaded new pathway
8538view14:02, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPUnknown58-64-0 (CAS)
ASKGeneProduct
ATPUnknown1927-31-7 (CAS)
CDC2GeneProduct851456 (Entrez Gene)
CDC45GeneProduct850793 (Entrez Gene)
CDC46GeneProduct850980 (Entrez Gene)
CDC47GeneProduct852501 (Entrez Gene)
CDC54GeneProduct856130 (Entrez Gene)
CDC6GeneProduct853244 (Entrez Gene)
CDC7GeneProduct851545 (Entrez Gene)
CDK2GeneProduct
CDT1GeneProduct
DPB2GeneProduct856305 (Entrez Gene)
GMNNGeneProduct
GTPUnknown2564-35-4 (CAS)
HYS2GeneProduct853462 (Entrez Gene)
MCM10GeneProduct854656 (Entrez Gene)
MCM2GeneProduct852258 (Entrez Gene)
MCM3GeneProduct856680 (Entrez Gene)
MCM6GeneProduct852673 (Entrez Gene)
ORC1LGeneProduct
ORC2GeneProduct852352 (Entrez Gene)
ORC3LGeneProduct
ORC4LGeneProduct
ORC5LGeneProduct
ORC6LGeneProduct
POL12GeneProduct852245 (Entrez Gene)
POL1GeneProduct855621 (Entrez Gene)
POL2GeneProduct855459 (Entrez Gene)
POL30GeneProduct852385 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
PRI1GeneProduct854825 (Entrez Gene)
PRI2GeneProduct853821 (Entrez Gene)
RFA1GeneProduct851266 (Entrez Gene)
RFA2GeneProduct855404 (Entrez Gene)
RFC1GeneProduct854392 (Entrez Gene)
RFC2GeneProduct853531 (Entrez Gene)
RFC3GeneProduct855426 (Entrez Gene)
RFC4GeneProduct854059 (Entrez Gene)
RFC5GeneProduct852383 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RPL40AGeneProduct854658 (Entrez Gene)
UBI4GeneProduct850620 (Entrez Gene)
dATPUnknown1927-31-7 (CAS)
dCTPUnknown2056-98-6 (CAS)
dGTPUnknown2564-35-4 (CAS)

Annotated Interactions

No annotated interactions
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