Non-homologous end joining (Drosophila melanogaster)

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Ku80Ku80DNA-PKcsIrbpIrbpIrbpDNA-PKcsKu80IrbpKu80NHEJ1DNA-PKcsIrbpKu80Ligase VXRCC4Ku80IrbpKu80DNA-PKcsXLFIrbpDNA-PKcsIrbpLigase VDNA-PKcsXRCC4rad50Ku80mre11Nbs1 ?IrbpKu80DNA-PKcsIrbpDNA-PKcsKu80


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 59% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
116927view09:45, 16 May 2021EweitzModified title
87936view13:03, 25 July 2016ElisaOntology Term : 'DNA repair pathway' added !
87933view13:03, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
79375view19:48, 21 March 2015Khanspersupdate schema
79374view19:47, 21 March 2015KhanspersModified title
79373view19:47, 21 March 2015KhanspersReverted to version '00:18, 21 February 2013' by Khanspers
70184view01:40, 13 July 2013AlexanderPicoModified title
68714view21:41, 6 July 2013MaintBotUpdated to 2013 gpml schema
58864view00:18, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
40880view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35400view09:53, 12 February 2010MartijnVanIerselModified description
31811view12:21, 14 August 2009MaintBotFixed group labels
30770view23:17, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
DNA-PKcsGeneProduct
IrbpGeneProductFBgn0011774 (Ensembl Fruitfly)
Ku80GeneProductFBgn0041627 (Ensembl Fruitfly)
Ligase VGeneProduct
NHEJ1GeneProduct
Nbs1 ?GeneProduct
XLFGeneProduct
XRCC4GeneProduct
mre11GeneProductFBgn0020270 (Ensembl Fruitfly)
rad50GeneProductFBgn0034728 (Ensembl Fruitfly)

Annotated Interactions

No annotated interactions
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