Mapk cascade (Mus musculus)

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1ActivatedRap1GAPGb and GgApoptosisGiNucleusp38 MAPK PathwayGrowth and MitogenesisGqStress Activated PathwaysHras1Elk1Mapk12Mapk14Rasa3Map2k7Map3k1RrasRapGAPIIMapk3Map3k3Map2k2BrafNrasMapk10Sipa1Map2k4Mtap2Mapk1MbpMap2k1Map2k3Map2k6Plcb3JunGTPKrasRaf1Map3k12Map2k4ArafGDPMap3k2


Description

The MAPK/ERK pathway is a signal transduction pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. This pathway is very complex and includes many protein components. The basic pathway shown in the figure (to the right) and described below includes the major components of the pathway. In many cell types, activation of this pathway promotes cell division.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP422(r21570) with a 90% conversion rate.

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Ontology Terms

 

Bibliography

  1. Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  2. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116722view10:02, 11 May 2021EweitzModified title
115735view09:47, 9 March 2021EgonwReplaced the WP id of a human pathways with the matching cow pathway
115460view08:18, 21 February 2021EgonwMade a pathway clickable
95771view14:24, 19 January 2018MkutmonHomology conversion update
71729view20:17, 17 October 2013MaintBotAutomated update of data sources
71318view17:16, 17 October 2013MaintBotAutomated update of data sources
69104view18:12, 8 July 2013MaintBotUpdated to 2013 gpml schema
67957view15:03, 28 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
62830view04:45, 3 May 2013MaintBotUpdated UniProt data source
41289view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
35459view11:53, 12 February 2010MichielAdded ref
35431view11:13, 12 February 2010MichielModified description
35430view11:12, 12 February 2010MichielModified description
35429view11:10, 12 February 2010MichielAdded literature reference
34388view22:50, 9 December 2009MaintBotAutomatic update of empty xrefs
32979view23:26, 29 September 2009MaintBotadded xrefs
32377view16:52, 15 August 2009MaintBotFixed text labels
32013view13:21, 14 August 2009MaintBotFixed group labels
31413view20:54, 13 August 2009MaintBotFixed text labels
30851view00:07, 30 July 2009MaintBotConverted from Homo sapiens
21207view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:MAPK Cascade]] moved to [[Pathway:WP251]]: Moved to stable identifier
8244view13:46, 7 January 2008MaintBot[[Pathway:Mouse:MAPK Cascade]] moved to [[Pathway:Mus musculus:MAPK Cascade]]: Renaming species
7742view16:14, 18 December 2007MaintBotfixed category names
7275view12:41, 4 November 2007MaintBotAdded categories to GPML
19506view22:19, 22 May 2007I.Reyesgpml file for [[Mouse:MAPK_Cascade]]
6473view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:MAPK_Cascade]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ArafGeneProduct11836 (Entrez Gene)
BrafGeneProduct109880 (Entrez Gene)
Elk1GeneProduct13712 (Entrez Gene)
GDPMetaboliteHMDB01201 (HMDB)
GTPMetaboliteHMDB01273 (HMDB)
Hras1GeneProduct15461 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
KrasGeneProduct16653 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Map2k3GeneProduct26397 (Entrez Gene)
Map2k4GeneProduct26398 (Entrez Gene)
Map2k6GeneProduct26399 (Entrez Gene)
Map2k7GeneProduct26400 (Entrez Gene)
Map3k12GeneProduct26404 (Entrez Gene)
Map3k1GeneProduct26401 (Entrez Gene)
Map3k2GeneProduct26405 (Entrez Gene)
Map3k3GeneProduct26406 (Entrez Gene)
Mapk10GeneProduct26414 (Entrez Gene)
Mapk12GeneProduct29857 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
MbpGeneProduct17196 (Entrez Gene)
Mtap2GeneProduct17756 (Entrez Gene)
NrasGeneProduct18176 (Entrez Gene)
Plcb3GeneProduct18797 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
RapGAPIIGeneProduct
Rasa3GeneProduct19414 (Entrez Gene)
RrasGeneProduct20130 (Entrez Gene)
Sipa1GeneProduct20469 (Entrez Gene) not confirmed SwissProt ID - mu: SPA1 MOUSE

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP251"
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