Calcium regulation in cardiac cell (Bos taurus)
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Revision as of 11:46, 12 February 2010 by
Thomas
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1
Ca
2+
Protein Kinase C
DAG
g
Calsequestrin S-Ca
G
G
Na+
CaM kinase
P
2+
Cytosolic Ca2+
PKA Inhibitors
Membrane
Depolarization
Calsequestrin C-Ca
bg
Ca
IP3
PIP2
IP4
K+
Ca
2+
GRK
Cytosolic Ca
K+
2+
Dihydropyridine-Sensitive
M1 Muscarinic Receptor
Cyclases
L-Type Ca2+ Channel
PKC inhibitor Protein-1
b
bg
Adrenergic Receptor
FKBP12
CaM kinase
K+
Ca
2+
Epinephrine
2+
Regulators of G-protein
Gap Junctions (Connexins)
2+
G
G alpha i/o/z
bg
Signaling
Adenylyl
ADP + Pi
arrestin/GRK
Adrenergic Receptor
cAMP
Phopholamban
Na+
Calreticulin-Ca
P
IP3 Receptors
G alpha i/o/z
arrestin/GRK
IP3 Receptors
Repolarization
G
Calmodulin
2+
Na+/K+ ATPase
2+
b
2+
Ca
Connexin
ADP + Pi
Na+/Ca2+ Exchanger
2+
Protein Kinase A
G
Na2+
2+
Ca
Ca
Adenylyl Cyclases
b
SR
Ca2+
Protein Kinase A
Cytosolic Ca
2+
Connexin
Epinephrine
a
Cytosol
beta Arrestin
Ca
b
PRKCH
RYR1
PRKAR1A
GNAI2
GNB1
ATP1B2
GNAO1
PRKCD
CASQ1
GJA5
CACNA1E
CAMK2G
GJA8
ADCY4
CHRM1
KCNB1
YWHAH
ATP1B1
PRKCB
GJB3
YWHAQ
ITPR2
PLCB3
ATP2B3
RGS5
PKIA
CASQ2
ADRA1A
CALM1
CACNB3
GNB4
CHRM3
RGS16
ITPR3
LOC100139910
CHRM2
ADCY7
YWHAE
CAMK4
ATP1B3
ADRB1
PLCB3
CAMK1
FKBP1A
RGS7
CHRM4
CAMK2A
ATP1A4
ATP
GNAI3
GNG8
GJD2
RGS1
ADP
GRK4
SFN
GRK5
FXYD2
RYR3
GJA4
GJC1
RGS11
RGS3
SLC8A1
GNG4
RGS6
RGS2
GNB5
PRKAR1B
ADRA1B
ITPR1
GJB1
GNGT1
KCNJ5
GNG2
GNG12
GNAI1
GNAQ
GNG11
PRKCH
ADRB2
GNG7
PRKAR2B
PRKACB
ADCY9
ADCY8
GNAS
RGS19
LOC517006
LOC781283
CACNA1D
ARRB2
LOC100140553
GNB2
CAMK2D
ANXA6
YWHAG
GJA3
PRKCG
SLC8A3
YWHAZ
PRKACA
ADCY2
CACNA1A
RGS4
RGS14
CAMK2B
PRKCZ
PRKCA
RGS18
RGS20
ADCY3
CHRM5
GJB5
ADRB3
GNG5
ATP
KCNJ3
GJA9
RGS10
ADRA1D
LOC615374
CALM2
LOC100140301
ATP
CACNA1S
PLN
ADCY5
PKIG
RYR2
CALM3
CACNA1C
ATP
ATP2A2
ARRB1
GNB3
GJC2
Acetylcholine
GJB6
YWHAB
ADCY6
CACNB1
ATP2B2
PRKCE
ATP2A3
PRKCQ
ADCY1
GNAZ
PRKD1
GNG3
ATP2B1
CALR
GJA1
RGS17
RGS9
CACNA1B
GRK6
GNA11
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP536(r21808)
with a 87% conversion rate.
Try the New WikiPathways
View approved pathways at
the new wikipathways.org
.
Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
Marks AR; ''Calcium and the heart: a question of life and death.''; J Clin Invest, 2003
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
117482
view
11:00, 21 May 2021
Eweitz
Modified title
107052
view
14:14, 17 September 2019
MaintBot
ChEBI identifier normalization
105971
view
11:50, 16 August 2019
MaintBot
HMDB identifier normalization
95757
view
14:13, 19 January 2018
Mkutmon
Homology conversion update
80736
view
15:24, 30 June 2015
Mkutmon
homology conversion
67762
view
12:07, 26 June 2013
Christine Chichester
Ontology Term : 'calcium/calcium-mediated signaling pathway' added !
63456
view
17:18, 10 May 2013
MaintBot
Updated to 2013 gpml schema
48137
view
05:55, 9 May 2012
MaintBot
Updating from human to fix xref duplication
40590
view
19:33, 1 March 2011
MaintBot
Removed redundant pathway information and comments
35451
view
11:46, 12 February 2010
Thomas
Modified description
35449
view
11:45, 12 February 2010
Thomas
added literature
33828
view
00:27, 9 December 2009
MaintBot
Automatic update of empty xrefs
32508
view
12:50, 17 August 2009
MaintBot
Fixed text labels
32198
view
12:37, 15 August 2009
MaintBot
Fixed text labels
31680
view
11:44, 14 August 2009
MaintBot
Fixed group labels
31206
view
19:35, 13 August 2009
MaintBot
Fixed text labels
30612
view
22:18, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ADCY1
GeneProduct
281601 (Entrez Gene)
CYA1 HUMAN
ADCY2
GeneProduct
510708 (Entrez Gene)
There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY3
GeneProduct
535603 (Entrez Gene)
ADCY4
GeneProduct
788151 (Entrez Gene)
There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY5
GeneProduct
505740 (Entrez Gene)
There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY6
GeneProduct
509936 (Entrez Gene)
ADCY7
GeneProduct
281603 (Entrez Gene)
ADCY8
GeneProduct
535017 (Entrez Gene)
ADCY9
GeneProduct
525482 (Entrez Gene)
ADP
Metabolite
ADRA1A
GeneProduct
282134 (Entrez Gene)
ADRA1B
GeneProduct
407140 (Entrez Gene)
ADRA1D
GeneProduct
539543 (Entrez Gene)
ADRB1
GeneProduct
281604 (Entrez Gene)
ADRB2
GeneProduct
281605 (Entrez Gene)
ADRB3
GeneProduct
281606 (Entrez Gene)
ANXA6
GeneProduct
327685 (Entrez Gene)
ARRB1
GeneProduct
281637 (Entrez Gene)
ARRB2
GeneProduct
281638 (Entrez Gene)
ATP1A4
GeneProduct
537960 (Entrez Gene)
ATP1B1
GeneProduct
519758 (Entrez Gene)
ATP1B2
GeneProduct
282562 (Entrez Gene)
ATP1B3
GeneProduct
532844 (Entrez Gene)
ATP2A2
GeneProduct
540568 (Entrez Gene)
ATP2A3
GeneProduct
512313 (Entrez Gene)
ATP2B1
GeneProduct
282641 (Entrez Gene)
ATP2B2
GeneProduct
613800 (Entrez Gene)
ATP2B3
GeneProduct
504353 (Entrez Gene)
ATP
Metabolite
Acetylcholine
Metabolite
CACNA1A
GeneProduct
282648 (Entrez Gene)
CACNA1B
GeneProduct
282410 (Entrez Gene)
CACNA1C
GeneProduct
787897 (Entrez Gene)
CACNA1D
GeneProduct
408013 (Entrez Gene)
CACNA1E
GeneProduct
353113 (Entrez Gene)
CACNA1S
GeneProduct
286801 (Entrez Gene)
CACNB1
GeneProduct
327703 (Entrez Gene)
CACNB3
GeneProduct
282160 (Entrez Gene)
CALM1
GeneProduct
617095 (Entrez Gene)
CALM2
GeneProduct
326597 (Entrez Gene)
CALM3
GeneProduct
520277 (Entrez Gene)
CALR
GeneProduct
281036 (Entrez Gene)
CAMK1
GeneProduct
520498 (Entrez Gene)
CAMK2A
GeneProduct
530719 (Entrez Gene)
CAMK2B
GeneProduct
525416 (Entrez Gene)
CAMK2D
GeneProduct
532713 (Entrez Gene)
CAMK2G
GeneProduct
282162 (Entrez Gene)
CAMK4
GeneProduct
CASQ1
GeneProduct
508394 (Entrez Gene)
CASQ2
GeneProduct
528555 (Entrez Gene)
CHRM1
GeneProduct
281684 (Entrez Gene)
CHRM2
GeneProduct
522170 (Entrez Gene)
CHRM3
GeneProduct
281685 (Entrez Gene)
CHRM4
GeneProduct
512928 (Entrez Gene)
CHRM5
GeneProduct
281686 (Entrez Gene)
FKBP1A
GeneProduct
539546 (Entrez Gene)
FXYD2
GeneProduct
281773 (Entrez Gene)
GJA1
GeneProduct
281193 (Entrez Gene)
GJA3
GeneProduct
407154 (Entrez Gene)
GJA4
GeneProduct
538913 (Entrez Gene)
GJA5
GeneProduct
539491 (Entrez Gene)
GJA8
GeneProduct
524042 (Entrez Gene)
GJA9
GeneProduct
782853 (Entrez Gene)
GJB1
GeneProduct
281194 (Entrez Gene)
GJB3
GeneProduct
539935 (Entrez Gene)
GJB5
GeneProduct
524030 (Entrez Gene)
GJB6
GeneProduct
508454 (Entrez Gene)
GJC1
GeneProduct
511119 (Entrez Gene)
GJC2
GeneProduct
538745 (Entrez Gene)
GJD2
GeneProduct
282577 (Entrez Gene)
GNA11
GeneProduct
281788 (Entrez Gene)
GNAI1
GeneProduct
281790 (Entrez Gene)
GNAI2
GeneProduct
281791 (Entrez Gene)
GNAI3
GeneProduct
539521 (Entrez Gene)
GNAO1
GeneProduct
281792 (Entrez Gene)
GNAQ
GeneProduct
536654 (Entrez Gene)
GNAS
GeneProduct
281793 (Entrez Gene)
GNAZ
GeneProduct
281200 (Entrez Gene)
GNB1
GeneProduct
281201 (Entrez Gene)
GNB2
GeneProduct
281202 (Entrez Gene)
GNB3
GeneProduct
513340 (Entrez Gene)
GNB4
GeneProduct
525962 (Entrez Gene)
GNB5
GeneProduct
535365 (Entrez Gene)
GNG11
GeneProduct
788596 (Entrez Gene)
GNG12
GeneProduct
286850 (Entrez Gene)
GNG2
GeneProduct
281203 (Entrez Gene)
GNG3
GeneProduct
281204 (Entrez Gene)
GNG4
GeneProduct
100125276 (Entrez Gene)
GNG5
GeneProduct
287018 (Entrez Gene)
GNG7
GeneProduct
618399 (Entrez Gene)
GNG8
GeneProduct
618470 (Entrez Gene)
GNGT1
GeneProduct
281796 (Entrez Gene)
GRK4
GeneProduct
512489 (Entrez Gene)
GRK5
GeneProduct
281801 (Entrez Gene)
GRK6
GeneProduct
ITPR1
GeneProduct
317697 (Entrez Gene)
ITPR2
GeneProduct
281878 (Entrez Gene)
ITPR3
GeneProduct
281879 (Entrez Gene)
KCNB1
GeneProduct
539528 (Entrez Gene)
KCNJ3
GeneProduct
526088 (Entrez Gene)
KCNJ5
GeneProduct
539844 (Entrez Gene)
LOC100139910
GeneProduct
100139910 (Entrez Gene)
LOC100140301
GeneProduct
100140301 (Entrez Gene)
LOC100140553
GeneProduct
100140553 (Entrez Gene)
LOC517006
GeneProduct
517006 (Entrez Gene)
LOC615374
GeneProduct
615374 (Entrez Gene)
LOC781283
GeneProduct
781283 (Entrez Gene)
PKIA
GeneProduct
613524 (Entrez Gene)
PKIG
GeneProduct
404169 (Entrez Gene)
PLCB3
GeneProduct
515669 (Entrez Gene)
PLN
GeneProduct
100125240 (Entrez Gene)
PRKACA
GeneProduct
282322 (Entrez Gene)
PRKACB
GeneProduct
282323 (Entrez Gene)
PRKAR1A
GeneProduct
615074 (Entrez Gene)
KAP0 HUMAN
PRKAR1B
GeneProduct
505370 (Entrez Gene)
PRKAR2B
GeneProduct
282463 (Entrez Gene)
PRKCA
GeneProduct
282001 (Entrez Gene)
PRKCB
GeneProduct
282325 (Entrez Gene)
PRKCD
GeneProduct
505708 (Entrez Gene)
PRKCE
GeneProduct
507041 (Entrez Gene)
This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
PRKCG
GeneProduct
282002 (Entrez Gene)
PRKCH
GeneProduct
518542 (Entrez Gene)
PRKCQ
GeneProduct
505901 (Entrez Gene)
PRKCZ
GeneProduct
286877 (Entrez Gene)
PRKD1
GeneProduct
533270 (Entrez Gene)
KPCM HUMAN
RGS10
GeneProduct
614550 (Entrez Gene)
RGS11
GeneProduct
521040 (Entrez Gene)
RGS14
GeneProduct
532605 (Entrez Gene)
RGS1
GeneProduct
540836 (Entrez Gene)
RGS16
GeneProduct
282035 (Entrez Gene)
RGS17
GeneProduct
504255 (Entrez Gene)
RGS18
GeneProduct
613624 (Entrez Gene)
RGS19
GeneProduct
539036 (Entrez Gene)
RGS20
GeneProduct
614441 (Entrez Gene)
RGS2
GeneProduct
616414 (Entrez Gene)
RGS3
GeneProduct
527349 (Entrez Gene)
RGS4
GeneProduct
617437 (Entrez Gene)
RGS5
GeneProduct
540509 (Entrez Gene)
RGS6
GeneProduct
517545 (Entrez Gene)
RGS7
GeneProduct
281452 (Entrez Gene)
RGS9
GeneProduct
281453 (Entrez Gene)
RYR1
GeneProduct
281473 (Entrez Gene)
RYR2
GeneProduct
537376 (Entrez Gene)
RYR3
GeneProduct
539899 (Entrez Gene)
SFN
GeneProduct
528453 (Entrez Gene)
SLC8A1
GeneProduct
337925 (Entrez Gene)
SLC8A3
GeneProduct
540307 (Entrez Gene)
YWHAB
GeneProduct
286863 (Entrez Gene)
YWHAE
GeneProduct
282125 (Entrez Gene)
YWHAG
GeneProduct
286862 (Entrez Gene)
YWHAH
GeneProduct
282126 (Entrez Gene)
YWHAQ
GeneProduct
768311 (Entrez Gene)
YWHAZ
GeneProduct
287022 (Entrez Gene)
PMID: 9861170 PMID: 1317796
Annotated Interactions
No annotated interactions
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View approved pathways at the new wikipathways.org.Quality Tags
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Bibliography
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External references
DataNodes
Annotated Interactions
No annotated interactions