Calcium regulation in cardiac cells (Danio rerio)

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12+Cytosolic CaProtein Kinase APIP2G2+bgbPCaM kinaseCaCaEpinephrinebeta ArrestinCaCalsequestrin S-CaG alpha i/o/z2+DAGSRIP3 ReceptorsK+2+Calreticulin-CaCalmodulinADP + PiCaDihydropyridine-SensitiveMembraneDepolarizationbAdenylylM1 Muscarinic ReceptorAdenylyl CyclasesAdrenergic ReceptorIP3 ReceptorsCyclasesPK+GIP3bEpinephrine2+bgCa2+bgProtein Kinase CPKC inhibitor Protein-1GPhopholambanG alpha i/o/zaCa2+ADP + PiNa+Calsequestrin C-CaFKBP12CaK+bConnexinCytosolic CagPKA InhibitorsNa+/Ca2+ ExchangerAdrenergic ReceptorCaarrestin/GRK2+2+ConnexinCytosolic Ca2+Na+/K+ ATPaseCytosolSignalingRegulators of G-proteinRepolarization2+2+2+Garrestin/GRKGRKNa+cAMPNa2+2+CaGap Junctions (Connexins)IP4L-Type Ca2+ ChannelCaM kinaseProtein Kinase A2+GLOC100003514zgc:154027zgc:153888gnai3LOC561288ATP1B3LOC564915LOC557123atp2a2atpteCACNA1Scamk2d2cx35rgs20chrm2agnai1prkcb1ATP1B2YWHAQcx34.4YWHAGLOC568010ARRB2atp2b2zgc:158799gng3LOC568726ADRA1Bryr3cacnb1GNB3LOC100150701RGS14CALM3CH73-270F14.2CH211-220F13.4chrm3RGS2YWHAZCACNB3FXYD2CH211-215F19.1LOC100000320camk4PLNPRKAR2Bchrm5aLOC798222ATP1B1ATPgnao1agng7LOC557353cx55.5DKEYP-60A7.2ATPLOC567452zgc:172124PKIBLOC792708LOC100149388GJA5cx44.1RGS10RGS1ATP1A4GRK4gng2LOC569499GNB4PRKCQLOC568614itpr2LOC100150195gnb5LOC555284gngt1LOC795659gnai2anxa6gng5prkar2aaLOC798498YWHABrgs5prkcezgc:172124ADCY6SFNgng12CALM2CACNA1Earrb1GJB5GNB1CAMK1RYR2ywhae1cx35.4LOC100149498slc8a1bLOC570659RGS3zgc:153624CH211-238E12.1rgs17zgc:171922CAMK2GPRKCDadcy2brgs6ywhahzgc:112145cacna1ccx33.8ADRB2zgc:92704LOC571888GJA12zgc:73189cx43LOC564307PKIGGJA4ADPcacna1acalrl2LOC571825PKIAFKBP1Azgc:101761cacna1dAcetylcholineLOC568671CALM1gnb2cx27.5ATPLOC100006640plcb3prkacbatp2b3batp2b1aprkczcamk2args4ADCY4ATPADCY9GNG11slc8a3casq2cx48.5zgc:110206rgs7adrb1plcb3RYR1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP536(r21808) with a 65% conversion rate.

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Ontology Terms

 

Bibliography

  1. Marks AR; ''Calcium and the heart: a question of life and death.''; J Clin Invest, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116853view10:48, 14 May 2021EweitzModified title
116852view10:47, 14 May 2021EweitzModified title
107098view14:18, 17 September 2019MaintBotChEBI identifier normalization
106078view11:59, 16 August 2019MaintBotHMDB identifier normalization
95759view14:13, 19 January 2018MkutmonHomology conversion update
71502view19:20, 17 October 2013MaintBotAutomated update of data sources
68618view04:03, 6 July 2013MaintBotUpdated to 2013 gpml schema
67772view13:56, 26 June 2013Christine ChichesterOntology Term : 'calcium/calcium-mediated signaling pathway' added !
47926view22:32, 18 April 2012Khanspersupdated xref
40780view22:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
35461view11:53, 12 February 2010ThomasModified description
35456view11:52, 12 February 2010Thomasadded literature
34171view21:18, 9 December 2009MaintBotAutomatic update of empty xrefs
32335view13:30, 15 August 2009MaintBotFixed text labels
31947view12:59, 14 August 2009MaintBotFixed group labels
31377view20:39, 13 August 2009MaintBotFixed text labels
31076view01:31, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY4GeneProductThere is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY6GeneProduct
ADCY9GeneProduct
ADPMetabolite
ADRA1BGeneProduct
ADRB2GeneProduct
ARRB2GeneProduct
ATP1A4GeneProduct
ATP1B1GeneProduct
ATP1B2GeneProduct
ATP1B3GeneProduct
ATPMetabolite
AcetylcholineMetabolite
CACNA1EGeneProduct
CACNA1SGeneProduct405791 (Entrez Gene)
CACNB3GeneProduct
CALM1GeneProduct
CALM2GeneProduct
CALM3GeneProduct
CAMK1GeneProduct
CAMK2GGeneProduct
CH211-215F19.1GeneProduct558248 (Entrez Gene)
CH211-220F13.4GeneProduct100148976 (Entrez Gene)
CH211-238E12.1GeneProduct555941 (Entrez Gene)
CH73-270F14.2GeneProduct570108 (Entrez Gene)
DKEYP-60A7.2GeneProduct562619 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
FKBP1AGeneProduct
FXYD2GeneProduct
GJA12GeneProduct
GJA4GeneProduct
GJA5GeneProduct
GJB5GeneProduct
GNB1GeneProduct322104 (Entrez Gene)
GNB3GeneProduct406483 (Entrez Gene)
GNB4GeneProduct
GNG11GeneProduct
GRK4GeneProduct
LOC100000320GeneProduct100000320 (Entrez Gene)
LOC100003514GeneProduct100003514 (Entrez Gene)
LOC100006640GeneProduct100006640 (Entrez Gene)
LOC100149388GeneProduct100149388 (Entrez Gene)
LOC100149498GeneProduct100149498 (Entrez Gene)
LOC100150195GeneProduct100150195 (Entrez Gene)
LOC100150701GeneProduct100150701 (Entrez Gene)
LOC555284GeneProduct555284 (Entrez Gene)
LOC557123GeneProduct557123 (Entrez Gene) KPCM HUMAN
LOC557353GeneProduct557353 (Entrez Gene)
LOC561288GeneProduct561288 (Entrez Gene)
LOC564307GeneProduct564307 (Entrez Gene)
LOC564915GeneProduct564915 (Entrez Gene)
LOC567452GeneProduct567452 (Entrez Gene)
LOC568010GeneProduct568010 (Entrez Gene)
LOC568614GeneProduct568614 (Entrez Gene)
LOC568671GeneProduct568671 (Entrez Gene)
LOC568726GeneProduct568726 (Entrez Gene)
LOC569499GeneProduct569499 (Entrez Gene) CYA1 HUMAN
LOC570659GeneProduct570659 (Entrez Gene)
LOC571825GeneProduct571825 (Entrez Gene)
LOC571888GeneProduct571888 (Entrez Gene)
LOC792708GeneProduct792708 (Entrez Gene)
LOC795659GeneProduct795659 (Entrez Gene)
LOC798222GeneProduct798222 (Entrez Gene)
LOC798498GeneProduct798498 (Entrez Gene)
PKIAGeneProduct
PKIBGeneProduct797348 (Entrez Gene)
PKIGGeneProduct503808 (Entrez Gene)
PLNGeneProduct
PRKAR2BGeneProduct
PRKCDGeneProduct334571 (Entrez Gene)
PRKCQGeneProduct555521 (Entrez Gene)
RGS1GeneProduct
RGS10GeneProduct
RGS14GeneProduct327368 (Entrez Gene)
RGS2GeneProduct436935 (Entrez Gene)
RGS3GeneProduct
RYR1GeneProduct
RYR2GeneProduct
SFNGeneProduct
YWHABGeneProduct
YWHAGGeneProduct
YWHAQGeneProduct
YWHAZGeneProductPMID: 9861170 PMID: 1317796
adcy2bGeneProduct557902 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
adrb1GeneProduct557194 (Entrez Gene)
anxa6GeneProduct353363 (Entrez Gene)
arrb1GeneProduct553266 (Entrez Gene)
atp2a2aGeneProduct393940 (Entrez Gene)
atp2b1aGeneProduct378746 (Entrez Gene)
atp2b2GeneProduct557430 (Entrez Gene)
atp2b3bGeneProduct558525 (Entrez Gene)
cacna1aGeneProduct562059 (Entrez Gene)
cacna1cGeneProduct170581 (Entrez Gene)
cacna1dGeneProduct403310 (Entrez Gene)
cacnb1GeneProduct436925 (Entrez Gene)
calrl2GeneProduct325317 (Entrez Gene)
camk2aGeneProduct550436 (Entrez Gene)
camk2d2GeneProduct436815 (Entrez Gene)
camk4GeneProduct550270 (Entrez Gene)
casq2GeneProduct114410 (Entrez Gene)
chrm2aGeneProduct352938 (Entrez Gene)
chrm3GeneProduct571679 (Entrez Gene)
chrm5aGeneProduct553978 (Entrez Gene)
cx27.5GeneProduct114405 (Entrez Gene)
cx33.8GeneProduct404725 (Entrez Gene)
cx34.4GeneProduct404727 (Entrez Gene)
cx35.4GeneProduct550380 (Entrez Gene)
cx35GeneProduct378444 (Entrez Gene)
cx43GeneProduct30236 (Entrez Gene)
cx44.1GeneProduct114403 (Entrez Gene)
cx48.5GeneProduct387533 (Entrez Gene)
cx55.5GeneProduct573483 (Entrez Gene)
gnai1GeneProduct393946 (Entrez Gene)
gnai2GeneProduct327650 (Entrez Gene)
gnai3GeneProduct100006888 (Entrez Gene)
gnao1aGeneProduct393760 (Entrez Gene)
gnb2GeneProduct541370 (Entrez Gene)
gnb5GeneProduct393719 (Entrez Gene)
gng12GeneProduct406604 (Entrez Gene)
gng2GeneProduct550256 (Entrez Gene)
gng3GeneProduct114462 (Entrez Gene)
gng5GeneProduct337838 (Entrez Gene)
gng7GeneProduct436670 (Entrez Gene)
gngt1GeneProduct335656 (Entrez Gene)
itpr2GeneProduct562585 (Entrez Gene)
plcb3GeneProduct100001532 (Entrez Gene)
prkacbGeneProduct563147 (Entrez Gene)
prkar2aaGeneProduct556042 (Entrez Gene)
prkcb1GeneProduct393953 (Entrez Gene)
prkceGeneProduct100005075 (Entrez Gene) This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
prkczGeneProduct555737 (Entrez Gene)
rgs17GeneProduct436796 (Entrez Gene)
rgs20GeneProduct436704 (Entrez Gene)
rgs4GeneProduct569876 (Entrez Gene)
rgs5GeneProduct573765 (Entrez Gene)
rgs6GeneProduct562667 (Entrez Gene)
rgs7GeneProduct436814 (Entrez Gene)
ryr3GeneProduct561350 (Entrez Gene)
slc8a1bGeneProduct797199 (Entrez Gene)
slc8a3GeneProduct560561 (Entrez Gene)
tpteGeneProduct327292 (Entrez Gene)
ywhae1GeneProduct322060 (Entrez Gene)
ywhahGeneProduct406443 (Entrez Gene)
zgc:101761GeneProduct493613 (Entrez Gene)
zgc:110206GeneProduct550519 (Entrez Gene)
zgc:112145GeneProduct550427 (Entrez Gene) KAP0 HUMAN
zgc:153624GeneProduct767685 (Entrez Gene)
zgc:153888GeneProduct768164 (Entrez Gene)
zgc:154027GeneProduct767757 (Entrez Gene)
zgc:158799GeneProduct564064 (Entrez Gene)
zgc:171922GeneProduct559197 (Entrez Gene)
zgc:172124GeneProduct100144561 (Entrez Gene)
zgc:73189GeneProduct793087 (Entrez Gene)
zgc:92704GeneProduct436673 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1365"
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