Mapk cascade (Rattus norvegicus)
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1
Activated
Rap1GAP
Apoptosis
Stress Activated Pathways
Nucleus
Growth and Mitogenesis
p38 MAPK Pathway
Gq
Gb and Gg
Gi
Mapk1
Map2k4
Map2k4
MBP
Raf1
Rasa3
Sipa1
GTP
Jun
RapGAPII
Map3k3
Braf
Map3k2
Kras
Plcb3
Elk1
Map2k6
Mapk3
GDP
Map2k1
Map2k2
Map3k1
Mapk10
Map2k7
Mapk14
Mapk12
Hras
Nras
Map2k3
Map2
Rras
Map3k12
Araf
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP422(r21570)
with a 87% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008
PubMed
Europe PMC
Scholia
Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
116825
view
10:18, 14 May 2021
Eweitz
Modified title
95772
view
14:24, 19 January 2018
Mkutmon
Homology conversion update
71797
view
20:33, 17 October 2013
MaintBot
Automated update of data sources
71304
view
16:59, 17 October 2013
MaintBot
Automated update of data sources
69419
view
19:02, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67439
view
11:02, 26 June 2013
Ddigles
Ontology Term : 'mitogen activated protein kinase signaling pathway' added !
62850
view
05:06, 3 May 2013
MaintBot
Updated UniProt data source
41742
view
02:40, 2 March 2011
MaintBot
Removed redundant pathway information and comments
35462
view
11:54, 12 February 2010
Michiel
Added ref
34115
view
19:25, 9 December 2009
MaintBot
Automatic update of empty xrefs
32434
view
17:14, 15 August 2009
MaintBot
Fixed text labels
32103
view
13:46, 14 August 2009
MaintBot
Fixed group labels
31455
view
21:12, 13 August 2009
MaintBot
Fixed text labels
30956
view
00:44, 30 July 2009
MaintBot
Converted from Homo sapiens
21618
view
11:32, 14 November 2008
MaintBot
[[Pathway:Rattus norvegicus:MAPK Cascade]] moved to [[Pathway:WP446]]: Moved to stable identifier
8246
view
13:46, 7 January 2008
MaintBot
[[Pathway:Rat:MAPK Cascade]] moved to [[Pathway:Rattus norvegicus:MAPK Cascade]]: Renaming species
7743
view
16:14, 18 December 2007
MaintBot
fixed category names
7276
view
12:41, 4 November 2007
MaintBot
Added categories to GPML
19507
view
22:20, 22 May 2007
I.Reyes
gpml file for [[Rat:MAPK_Cascade]]
6573
view
22:20, 22 May 2007
Nsalomonis
gpml file for [[Rat:MAPK_Cascade]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
Araf
GeneProduct
64363 (Entrez Gene)
Braf
GeneProduct
114486 (Entrez Gene)
Elk1
GeneProduct
314436 (Entrez Gene)
GDP
Metabolite
GTP
Metabolite
Hras
GeneProduct
293621 (Entrez Gene)
Jun
GeneProduct
24516 (Entrez Gene)
Kras
GeneProduct
24525 (Entrez Gene)
MBP
GeneProduct
24547 (Entrez Gene)
Map2
GeneProduct
25595 (Entrez Gene)
Map2k1
GeneProduct
170851 (Entrez Gene)
Map2k2
GeneProduct
58960 (Entrez Gene)
Map2k3
GeneProduct
303200 (Entrez Gene)
Map2k4
GeneProduct
287398 (Entrez Gene)
Map2k6
GeneProduct
114495 (Entrez Gene)
Map2k7
GeneProduct
363855 (Entrez Gene)
Map3k1
GeneProduct
116667 (Entrez Gene)
Map3k12
GeneProduct
25579 (Entrez Gene)
Map3k2
GeneProduct
171492 (Entrez Gene)
Map3k3
GeneProduct
303604 (Entrez Gene)
Mapk10
GeneProduct
25272 (Entrez Gene)
Mapk1
GeneProduct
116590 (Entrez Gene)
Mapk12
GeneProduct
60352 (Entrez Gene)
Mapk14
GeneProduct
81649 (Entrez Gene)
Mapk3
GeneProduct
50689 (Entrez Gene)
Nras
GeneProduct
24605 (Entrez Gene)
Plcb3
GeneProduct
29322 (Entrez Gene)
Raf1
GeneProduct
24703 (Entrez Gene)
RapGAPII
GeneProduct
Rasa3
GeneProduct
29372 (Entrez Gene)
Rras
GeneProduct
361568 (Entrez Gene)
Sipa1
GeneProduct
361710 (Entrez Gene)
not confirmed SwissProt ID - mu: SPA1 MOUSE
Annotated Interactions
No annotated interactions
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